Results 11 to 20 of about 724,197 (388)

The versatile heparin in COVID‐19

Journal of Thrombosis and Haemostasis, 2020
Coagulopathy in corona virus infection has been shown to be associated with high mortality with high D-dimers being a particularly important marker for the coagulopathy.1 In the latest paper from the same group, the use of anticoagulant therapy with ...
J. Thachil
semanticscholar   +1 more source

Quantitative Analysis of Impurities in Unfractionated Heparin of Bovine Origin

Frontiers in Medicine, 2020
The USP heparin sodium monograph lists impurities with specifications developed for porcine derived products. Most of these impurities are of biological origin and are present in porcine intestinal mucosa, the tissue source used in the production of ...
Wesley E. Workman, Kevin L. Carrick
doaj   +1 more source

Heparin-induced thrombocytopenia occurring early after living donor liver transplantation: a case report

Emergency and Critical Care Medicine, 2023
. Background. Thrombocytopenia commonly occurs early after liver transplantation. Heparin, usually administered as anticoagulant therapy for thrombosis, a common complication after liver transplantation, may cause heparin-induced thrombocytopenia ...
Naoya Iwasaki, Motohiro Sekino, Takanobu Hara, Akihiko Soyama, Masaaki Hidaka, Yusuke Kasai, Miki Suzumura, Hiroshi Araki, Rintaro Yano, Sojiro Matsumoto, Taiga Ichinomiya, Ushio Higashijima, Susumu Eguchi, Tetsuya Hara   +13 more
doaj   +1 more source

Poly-ion complex (PIC) formation of heparin and polyamines: PIC with tetrakis (3-aminopropyl) ammonium allows sustained release of heparin

Heliyon, 2020
Physical mixtures of cationic polymers and heparin have been developed to overcome the limitations of unfractionated heparin. In this study, we found that heparin associates with natural polyamines in water, resulting in the generation of a poly-ion ...
Daichi Ito, Dan Ge, Noriyuki Kogure, Hitomi Manaka, Yusuke Terui, Hiromitsu Takayama, Robert J. Linhardt, Toshihiko Toida, Kyohei Higashi   +8 more
doaj   +1 more source

Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin

Thrombosis and Haemostasis, 2020
The dependence of development and homeostasis in animals on the interaction of hundreds of extracellular regulatory proteins with the peri- and extracellular glycosaminoglycan heparan sulfate (HS) is exploited by many microbial pathogens as a means of ...
Courtney J. Mycroft-West, Dunhao Su, I. Pagani, T. Rudd, S. Elli, Neha S. Gandhi, S. Guimond, G. Miller, Maria C. Z. Meneghetti, H. Nader, Yong Li, Q. Nunes, P. Procter, N. Mancini, M. Clementi, A. Bisio, N. Forsyth, V. Ferro, J. Turnbull, M. Guerrini, D. Fernig, E. Vicenzi, E. Yates, M. Lima, M. Skidmore   +24 more
semanticscholar   +1 more source

The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding

bioRxiv, 2020
Many pathogens take advantage of the dependence of the host on the interaction of hundreds of extracellular proteins with the glycosaminoglycans heparan sulphate to regulate homeostasis and use heparan sulphate as a means to adhere and gain access to ...
Courtney J. Mycroft-West, Dunhao Su, S. Elli, Yong Li, S. Guimond, G. Miller, J. Turnbull, E. Yates, M. Guerrini, D. Fernig, M. Lima, M. Skidmore   +11 more
semanticscholar   +1 more source

Heparin modification of a biomimetic bone matrix modulates osteogenic and angiogenic cell response in vitro [PDF]

European Cells & Materials, 2017
In this study, the effect of heparin-modified collagen type I/hydroxyapatite (HA) nanocomposites on key processes of bone regeneration – osteogenesis and angiogenesis – was characterised in vitro.
M Quade, S Knaack, D Weber, U König, B Paul, P Simon, A Rösen-Wolff, R Schwartz-Albiez, M Gelinsky, A Lode   +9 more
doaj   +1 more source

Heparin as a therapy for COVID-19: current evidence and future possibilities

American Journal of Physiology - Lung cellular and Molecular Physiology, 2020
Coronavirus disease 2019 (COVID-19), the clinical syndrome associated with infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has impacted nearly every country in the world.
J. Hippensteel, W. LaRivière, James F. Colbert, Christophe J. Langouët-Astrié, E. Schmidt   +4 more
semanticscholar   +1 more source

Heparin resistance in COVID-19 patients in the intensive care unit

Journal of Thrombosis and Thrombolysis, 2020
Patients with COVID-19 have a coagulopathy and high thrombotic risk. In a cohort of 69 intensive care unit (ICU) patients we investigated for evidence of heparin resistance in those that have received therapeutic anticoagulation.
D. White, S. MacDonald, T. Bull, M. Hayman, R. D. Monteverde-Robb, D. Sapsford, A. Lavinio, J. Varley, A. Johnston, M. Besser, W. Thomas   +10 more
semanticscholar   +1 more source

Serologic characterization of anti-protamine/heparin and anti-PF4/heparin antibodies

Blood Advances, 2017
: Anti-protamine (PRT)/heparin antibodies are a newly described class of heparin-dependent antibodies occurring in patients exposed to PRT and heparin during cardiac surgery.
Grace M. Lee, Manali Joglekar, Maragatha Kuchibhatla, Sanjay Khandelwal, Rui Qi, Lubica Rauova, Gowthami M. Arepally   +6 more
doaj   +1 more source