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The anti-cancer properties of heparin and its derivatives: a review and prospect
Cell Adhesion & Migration, 2020 Heparin, including unfractionated heparin (UFH), low-molecular-weight heparin (LMWH) and heparin derivatives, are commonly used in venous thromboembolism treatment and reportedly have beneficial effects on cancer survival.Sai-Nan Ma, Zhi-Xiang Mao, Yang Wu, Ming-Xing Liang, Dan-Dan Wang, Xiu Chen, Ping-an Chang, Wei Zhang, Jin-Hai Tang +8 moredoaj +2 more sourcesEfficacy and Safety of Therapeutic-Dose Heparin vs Standard Prophylactic or Intermediate-Dose Heparins for Thromboprophylaxis in High-risk Hospitalized Patients With COVID-19: The HEP-COVID Randomized Clinical Trial.
JAMA Internal Medicine, 2021 Importance
Hospitalized patients with COVID-19 are at risk for venous and arterial thromboembolism and death. Optimal thromboprophylaxis dosing in high-risk patients is unknown.
Objective
To evaluate the effects of therapeutic-dose low-molecular-weight A. Spyropoulos, M. Goldin, D. Giannis, W. Diab, Janice Wang, S. Khanijo, A. Mignatti, E. Gianos, Marc Cohen, G. Sharifova, J. M. Lund, A. Tafur, P. A. Lewis, Kevin P. Cohoon, H. Rahman, C. Sison, M. Lesser, K. Ochani, Nirav Agrawal, J. Hsia, V. Anderson, M. Bonaca, J. Halperin, J. Weitz +23 moresemanticscholar +1 more sourceEffectiveness of therapeutic heparin versus prophylactic heparin on death, mechanical ventilation, or intensive care unit admission in moderately ill patients with covid-19 admitted to hospital: RAPID randomised clinical trial
British medical journal, 2021 Objective To evaluate the effects of therapeutic heparin compared with prophylactic heparin among moderately ill patients with covid-19 admitted to hospital wards. Design Randomised controlled, adaptive, open label clinical trial. Setting 28 hospitals in M. Sholzberg, Grace H Tang, Hassan Rahhal, M. AlHamzah, L. B. Kreuziger, F. Áinle, F. Alomran, Khalid Alayed, M. Alsheef, Fahad AlSumait, C. E. Pompilio, C. Sperlich, S. Tangri, Terence Tang, Peter Jaksa, D. Suryanarayan, M. Almarshoodi, L. Castellucci, P. James, D. Lillicrap, M. Carrier, A. Beckett, C. Colovos, J. Jayakar, M. Arsenault, Cynthia Wu, K. Doyon, E. Andreou, Vera Dounaevskaia, E. Tseng, Gloria Lim, M. Fralick, S. Middeldorp, Agnes Y. Y. Lee, F. Zuo, Bruno R. da Costa, K. Thorpe, E. Negri, M. Cushman, P. Jüni, A. Laupacis, Yulia Lin, Andrew G. Day, B. Rochwerg, J. Abdulrehman, M. Gergi, R. Kondo, B. Piloto, Guilherme de Abreu Pereira, F. Valente, Ariel Fernando Villarroel Agreda, Pablo Andres Munoz Torres, Maíra Oliveira Moraes, Claudia de Lucena Moreira, Fernando Galassi Stocco Neto, Fabíola Vieira Duarte Baptista, J. A. Moreira, Augusto Séttemo Ferreira, Paula Frudit, G. Martínez, H. P. Souza, R. A. B. Neto, E. D’Amico, E. Padrão, Fernando Sarin da Mota e Albuquerque, G. Zangrossi, A. K. Kanasiro, Alissom Vitti Cincoto, Hugo de Souza Reis, Vitor Miyashiro Arias da Silva, A. Bellintani, Vivian dos Santos Pereira, Yohan Washington de Oliveira, B. J. Carvalho, Mariana de Souza Novaes, Henrique Brito Silveira, Gabriel César Alves de Avelar, Lara Bonanni Mota, Karina Caciola, Matheus de Arêa Leão Freire Marim, Tales Cabral Monsalvarga, Alexandre Salgado Blanco Santos, A. Haydar, Gabriella Seixas Sampaio Saraiva, Sabrina Correa da Costa Ribeiro, Julio Flavio Meirelles Marchini, Julio Cesar Garcia de Alencar, Ana Catharina de Seixas Santos, Caroline Millette, M. Lebeau, Céline Devaux, M. Boutin, T. N. Nguyen, L. Srour, Flávia De Angelis, Mariane Fugulin, A. Binnie, S. A. Bejaimal, A. Binding, Rosa M. Marticorena, G. Ginocchio, E. Kaplovitch, K. Rymaszewski, A. Raissi, Marcelo A. Falappa, Blair Ernst, A. Ali, M. Romano, Mobina Khurram, Christie Kim, A. Kapur, Michelle L. Edwards, Vidushi Swarup, B. Camilotti, J. Jani, Jeff Carter, Mark R. Gillrie, Davinder Sidhu, Traci Robinson, Krystina Stutely, I. Watpool, R. Porteous, K. Jao, Jean-Samuel Boudreault-Pedneault, Christopher E. Kandel, Maureen Taylor, Wei En Enoch Choo, Laura Parsons, Ann Dowbenka, Gitana Ramonas, S. Nikitin, Jeffery M. Patterson, M. Hnatiuk, Anca Tapardel, S. T. Lapner, T. Carpenter, Lori Rackel, Rebecca M. Cairns, Jessica Pinder, P. Anglin, Catherine McPherson, Liselle Chiverton, David Barbosa, Shany Loukiantchenko, Y. Shamiss, D. Tassy, S. Shivakumar, Mary M. Keating, Susan Pleasance, B. Kevane, S. Cullivan, N. Power, P. Doran, K. Leamy, Aoife C Kelly, Conor Moran, Mairead O’Connor, Aoife McDonnell, Roseanne Boyce, Faiza Sefroun, R. Hussain, P. Murray, A. Malara, B. Molloy, Meadbh O’Halloran, Emer Cunningham, J. Lambert, A. Cotter, B. Marsh, G. Sheehan, E. Muldoon, J. Woo, S. Gaine, Deirdre Morley, Farjah H Algahtani, I. Almaghlouth, Sondus I. Ata, Fai Alkhathlan, N. Khalil, Israa Mohamed Hussein, Mohammed Bashir, Ahmed S. Bahammam, A. Alsultan, H. Alkofide, Tariq M. Alhawassi, Abdulhadi M Alqahtani, E. Zayed, A. Alsughayir, Yacoub Abuzied, H. Alzahrani, Jawaher M Al-Otaibi, Haya S Alothaimeen, Noura Alzannan, Amer Al Homssi, H. Abid, S. Jones, S. Broaddrick, N. Jain, R. King, M. Jindal, Kristen M. Sanfilippo, Patty Nieters, Muhammad Hammad, Aleeswa Francis Benny, Tariq A. Hamdan, Suhaib Kamal Ahmed Elobaid, Ibrahim Khafagi, S. S. Ahmed, AbduleRehman AlEssaie, Shamma Alalawi, Khloud Bashir, Aysha Abdulla Salem Al Suwaidi, H. I. Ahmed, Mohamed Milad Ismail, El Mutasim Ahmed El Faki, Mercy Charles, Alice Dang, Gurpreet Lakhanpal, Dominic Lee, Prachi Ray, M. Naydenova, K. Wysocki, Aziz Jiwajee, Greg Wendling, Rebekah H. Boyle, E. Cornell, D. K. Mukaz +226 moresemanticscholar +1 more sourceThe versatile heparin in COVID‐19
Journal of Thrombosis and Haemostasis, 2020 Coagulopathy in corona virus infection has been shown to be associated with high mortality with high D-dimers being a particularly important marker for the coagulopathy.1 In the latest paper from the same group, the use of anticoagulant therapy with ...J. Thachilsemanticscholar +1 more sourceHeparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin
Thrombosis and Haemostasis, 2020 The dependence of development and homeostasis in animals on the interaction of hundreds of extracellular regulatory proteins with the peri- and extracellular glycosaminoglycan heparan sulfate (HS) is exploited by many microbial pathogens as a means of ...Courtney J. Mycroft-West, Dunhao Su, I. Pagani, T. Rudd, S. Elli, Neha S. Gandhi, S. Guimond, G. Miller, Maria C. Z. Meneghetti, H. Nader, Yong Li, Q. Nunes, P. Procter, N. Mancini, M. Clementi, A. Bisio, N. Forsyth, V. Ferro, J. Turnbull, M. Guerrini, D. Fernig, E. Vicenzi, E. Yates, M. Lima, M. Skidmore +24 moresemanticscholar +1 more sourceThe 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding
bioRxiv, 2020 Many pathogens take advantage of the dependence of the host on the interaction of hundreds of extracellular proteins with the glycosaminoglycans heparan sulphate to regulate homeostasis and use heparan sulphate as a means to adhere and gain access to ...Courtney J. Mycroft-West, Dunhao Su, S. Elli, Yong Li, S. Guimond, G. Miller, J. Turnbull, E. Yates, M. Guerrini, D. Fernig, M. Lima, M. Skidmore +11 moresemanticscholar +1 more sourceHeparin resistance in COVID-19 patients in the intensive care unit
Journal of Thrombosis and Thrombolysis, 2020 Patients with COVID-19 have a coagulopathy and high thrombotic risk. In a cohort of 69 intensive care unit (ICU) patients we investigated for evidence of heparin resistance in those that have received therapeutic anticoagulation.D. White, S. MacDonald, T. Bull, M. Hayman, R. D. Monteverde-Robb, D. Sapsford, A. Lavinio, J. Varley, A. Johnston, M. Besser, W. Thomas +10 moresemanticscholar +1 more sourceHeparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the surface protein (spike) S1 receptor binding domain with heparin
bioRxiv, 2020 The dependence of the host on the interaction of hundreds of extracellular proteins with the cell surface glycosaminoglycan heparan sulphate (HS) for the regulation of homeostasis is exploited by many microbial pathogens as a means of adherence and ...Courtney J. Mycroft-West, Dunhao Su, I. Pagani, T. Rudd, S. Elli, S. Guimond, G. Miller, Maria C. Z. Meneghetti, H. Nader, Yong Li, Q. Nunes, P. Procter, N. Mancini, M. Clementi, A. Bisio, N. Forsyth, J. Turnbull, M. Guerrini, D. Fernig, E. Vicenzi, E. Yates, M. Lima, M. Skidmore +22 moresemanticscholar +1 more source
