Results 21 to 30 of about 724,197 (388)

Blended Heparin: A new Perspective to Guarantee the Supply of a Life-Saving Drug?

Clinical and Applied Thrombosis/Hemostasis, 2023
The risk of heparin shortage opens up the possibility of diversifying the sources of heparin by introducing products of other animal/organ origins. In addition to bovine heparin, already used in the past in the United States and Europe, ovine heparin can
Marco Guerrini MS
doaj   +1 more source

Heparin-induced thrombocytopenia: a rare presentation with skin necrosis

Dermatology Reports, 2023
Heparin-induced thrombocytopenia is the most clinically relevant non-haemorrhagic complication of heparin and is characterised by the presence of anti-PF4/heparin-IgG antibodies.
Filipa David, Ana Catarina Trigo, José Ribeiro, Joana Cancela   +3 more
doaj   +1 more source

American Society of Hematology 2018 guidelines for management of venous thromboembolism: heparin-induced thrombocytopenia.

Blood Advances, 2018
BACKGROUND Heparin-induced thrombocytopenia (HIT) is an adverse drug reaction mediated by platelet-activating antibodies that target complexes of platelet factor 4 and heparin. Patients are at markedly increased risk of thromboembolism. OBJECTIVE These
A. Cuker, G. Arepally, B. Chong, D. Cines, A. Greinacher, Y. Gruel, L. Linkins, Stephen B Rodner, S. Selleng, T. Warkentin, A. Wex, R. Mustafa, R. Morgan, N. Santesso   +13 more
semanticscholar   +1 more source

Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the surface protein (spike) S1 receptor binding domain with heparin

bioRxiv, 2020
The dependence of the host on the interaction of hundreds of extracellular proteins with the cell surface glycosaminoglycan heparan sulphate (HS) for the regulation of homeostasis is exploited by many microbial pathogens as a means of adherence and ...
Courtney J. Mycroft-West, Dunhao Su, I. Pagani, T. Rudd, S. Elli, S. Guimond, G. Miller, Maria C. Z. Meneghetti, H. Nader, Yong Li, Q. Nunes, P. Procter, N. Mancini, M. Clementi, A. Bisio, N. Forsyth, J. Turnbull, M. Guerrini, D. Fernig, E. Vicenzi, E. Yates, M. Lima, M. Skidmore   +22 more
semanticscholar   +1 more source

An Ovarian Cancer Patient Presenting Heparin - Induced Thrombocytopenia after use of Low - Molecular - Weight Heparin: A Case Report of Rare Condition

Gynecology Obstetrics & Reproductive Medicine, 2019
Heparin-induced thrombocytopenia is a rare and life-threatening condition of exposure to heparin. A case of heparin-induced thrombocytopenia due to the low molecular weight heparin was presented.
Yasin Durmuş, Yalin Ay Karyal, Cigdem Kilic, Caner Cakir, Dilek Yuksel, Berna Seyhan, Gokhan Boyraz, Gunsu Kimyon Comert, Taner Turan   +8 more
doaj   +1 more source

pH-Sensitive Chitosan–Heparin Nanoparticles for Effective Delivery of Genetic Drugs into Epithelial Cells [PDF]

, 2019
Chitosan has been extensively studied as a genetic drug delivery platform. However, its efficiency is limited by the strength of DNA and RNA binding.
Korzhikov-Vlakh, Viktor, Pilipenko, Iuliia, Rühl, Eckart, Schäfer-Korting, Monika, Sharoyko, Vladimir, Tennikova, Tatiana, Zhang, Nan, Zoschke, Christian   +7 more
core   +1 more source

Rivaroxaban Treatment for Heparin-Induced Thrombocytopenia: A Case Report and a Review of the Current Experience

Case Reports in Hematology, 2020
Heparin-induced thrombocytopenia is a life-threatening complication of exposure to heparin. Heparin-induced thrombocytopenia results from an autoantibody directed against platelet factor 4 in complex with heparin.
Mohamed Aon, Omar Al-Shammari
doaj   +1 more source

Graft-preserving intervention for treatment of heparin-induced thrombocytopenia secondary to a heparin-bonded renal artery bridging stent graft

Annals of Vascular Surgery - Brief Reports and Innovations, 2023
Heparin Induced Thrombocytopenia (HIT) is a well-recognized phenomenon in patients receiving heparin. Scoring systems such as the 4T score along with platelet factor 4 (PF4) testing have improved recognition and clinical improvement is typically observed
C.Y. Maximilian Png, John Schell, Alyssa M. Flores, Walter Dzik, Rebecca K. Leaf, Abhisekh Mohapatra   +5 more
doaj   +1 more source

The ISFET based heparin sensor with a monolayer of protamine as affinity ligand [PDF]

, 1995
The ion-step measuring method was used to determine absolute heparin concentrations in PBS and blood plasma with a Ta2O5 ISFET on to which a monolayer of protamine had been immobilized. Heparin is a highly negatively charged polysaccharide, which is used
Bergveld, P., Kerkhof, J.C. van, Schasfoort, R.B.M.   +2 more
core   +2 more sources

Nebulized heparin in burn patients with inhalation trauma : safety and feasibility [PDF]

, 2020
Background: Pulmonary hypercoagulopathy is intrinsic to inhalation trauma. Nebulized heparin could theoretically be beneficial in patients with inhalation injury, but current data are conflicting.
Binnekade, Jan M., Cleffken, Berry, Colpaert, Kirsten, Dixon, Barry, Glas, Gerie J., Hollmann, Markus W., Horn, Janneke, Juffermans, Nicole P., Knape, Paul, Levi, Marcel M., Loef, Bert G., Mackie, David P., Malbrain, Manu, Muller, Jan, Preckel, Benedikt, Reidinga, Auke C., Schultz, Marcus J., van der Sluijs, K.F.   +17 more
core   +2 more sources