Results 21 to 30 of about 522,479 (352)

Effects of Heparin and Enoxaparin on APP Processing and Aβ Production in Primary Cortical Neurons from Tg2576 Mice [PDF]

, 2015
BACKGROUND Alzheimer's disease (AD) is caused by accumulation of Aβ, which is produced through sequential cleavage of β-amyloid precursor protein (APP) by the β-site APP cleaving enzyme (BACE1) and γ-secretase.
Cui, Hao, Freeman, Craig, Hung, Amos C., Jacobson, Glenn A., Klaver, David W., Narkowicz, Christian, Small, David H., Suzuki, Toshiharu   +7 more
core   +1 more source

Interactions between heparin and SARS-CoV-2 spike glycoprotein RBD from omicron and other variants

Frontiers in Molecular Biosciences, 2022
Heparan sulfate (HS) acts as a co-receptor of angiotensin-converting enzyme 2 (ACE2) by interacting with severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) spike glycoprotein (SGP) facilitating host cell entry of SARS-CoV-2 virus ...
Adrianne L. Gelbach, Fuming Zhang, Seok-Joon Kwon, John T. Bates, Andrew P. Farmer, Jonathan S. Dordick, Jonathan S. Dordick, Chunyu Wang, Chunyu Wang, Robert J. Linhardt, Robert J. Linhardt, Robert J. Linhardt   +11 more
doaj   +1 more source

Interaction of antithrombin III with surface-immobilized albumin-heparin conjugates [PDF]

, 1995
The interaction between antithrombin III (ATIII) and albumin-heparin conjugates covalently coupled onto carboxylated polystyrene beads either in buffer containing albumin or in plasma was studied using 14C-labeled ATIII.
Delden, C.J. van, Engbers, G.H.M., Feijen, Jan   +2 more
core   +2 more sources

Understanding heparin-induced thrombosis: A brief review

Medicina Universitaria, 2021
Heparin has been the first line for treatment and prevention of thrombosis for a while. However, one of its non-hemorrhagic effects remains noticeable: heparin-induced thrombocytopenia, mediated by antibodies directed to complexes of platelet factor, and
Mariela Irabien-Zúñiga, Edgar A. Rojas-Guerrero, David Gómez-Almaguer   +2 more
doaj   +1 more source

Release of macromolecules from albumin-heparin microspheres [PDF]

, 1992
Hydrophilic microspheres based on albumin-heparin conjugates have been prepared as a macromolecular delivery system. The soluble albumin-heparin conjugate was synthesized and crosslinked in a water-in-oil emulsion with glutaraldehyde to form microspheres
Bae, You Han, Cremers, H.F.M., Cremers, Harry, Feijen, Jan, Kim, Sung Wan, Kwon, Glen S.   +5 more
core   +2 more sources

Heparin-induced thrombocytopenia among patients of a comprehensive cancer center

SAGE Open Medical Case Reports, 2014
Most clinical studies of heparin-induced thrombocytopenia have not included cancer patients who have high risk of thromboembolism, frequent exposure to heparin, and many potential causes of thrombocytopenia other than heparin-induced thrombocytopenia. To
Weixin Wu, Kelly Merriman, Amr Nabaah, Nikhil Seval, Vahid Afshar-Kharghan, Sai-Ching J Yeung   +5 more
doaj   +1 more source

Albumin-heparin microspheres as carriers for cytostatic agents [PDF]

, 1990
Much work has been done on adriamycin-loaded albumin microspheres (Alb-MS) for chemoembolization [1–4], the rationale being that site-specific drug delivery may increase the therapeutic efficacy of the drug. Alb-Ms are being investigated because of their
Bae, Y.H., Cremers, H.F.M., Feijen, J., Kim, S.W., Kwon, G., McVie, J.G., Noteborn, H.P.J.M.   +6 more
core   +2 more sources

Living kidney transplantation without perioperative anticoagulation therapy for a patient with heparin‐induced thrombocytopenia

IJU Case Reports, 2020
Introduction Heparin‐induced thrombocytopenia is an antibody‐mediated acquired prothrombotic state induced by heparin exposure. The risk of thromboembolic diseases in kidney transplantation with heparin‐induced thrombocytopenia without perioperative ...
Hayato Nishida, Hiroki Fukuhara, Atsushi Yamagishi, Noriyuki Hosoya, Osamu Ichiyanagi, Toshihiko Sakurai, Sei Naito, Takuya Yamanobe, Tomoyuki Kato, Norihiko Tsuchiya   +9 more
doaj   +1 more source

Efficient Heparin Recovery from Porcine Intestinal Mucosa Using Zeolite Imidazolate Framework-8

Molecules, 2022
Heparin is one of the most valuable active pharmaceutical ingredients, and it is generally isolated from porcine intestinal mucosa. Traditionally, different types of commercial resins are employed as an adsorbent for heparin uptake; however, using new ...
Mahmood Karimi Abdolmaleki, Deepak Ganta, Ali Shafiee, Carlo Alberto Velazquez, Devang P. Khambhati   +4 more
doaj   +1 more source

Lipolysis generates platelet dysfunction after in vivo heparin administration [PDF]

, 2002
Heparin, when administered to patients undergoing operations using cardiopulmonary bypass, induces plasma changes that gradually impair platelet macroaggregation, but heparinization of whole blood in vitro does not have this effect.
Belcher, P.R., Caslake, M.J., Chaudhry, M.A., Day, S., Muriithi, E.W., Wheatley, D.J.   +5 more
core   +1 more source