Three-fold mechanism of inhibition of SARS-CoV-2 infection by the interaction of the spike glycoprotein with heparin [PDF]
arXiv, 2021 Heparin has been found to have antiviral activity against SARS-CoV-2. Here, by means of sliding window docking, molecular dynamics simulations and biochemical assays, we investigate the binding mode of heparin to the virus spike glycoprotein and the molecular basis for its antiviral activity.
arxiv
Anti-platelet factor 4/polyanion antibodies mediate a new mechanism of autoimmunity [PDF]
, 2020 Antibodies recognizing complexes of the chemokine platelet factor 4 (PF4-CXCL4) and polyanions (P) opsonize PF4-coated bacteria hereby mediating bacterial host defense. A subset of these antibodies may activate platelets after binding to PF4-heparin complexes, causing the prothrombotic adverse drug reaction heparin-induced thrombocytopenia (HIT).
arxiv +1 more source
Chlorination and oxidation of heparin and hyaluronan by hypochlorous acid and hypochlorite anions: effect of sulfate groups on reaction pathways and kinetics. [PDF]
, 2013 Hypochlorous acid (HOCl), produced in inflammatory conditions by the enzyme myeloperoxidase, and its anion hypochlorite (OCl(-)) exist in vivo at almost equal concentrations.
Akeel, A +4 more
core +1 more source
Model Based Reinforcement Learning for Personalized Heparin Dosing [PDF]
arXiv, 2023 A key challenge in sequential decision making is optimizing systems safely under partial information. While much of the literature has focused on the cases of either partially known states or partially known dynamics, it is further exacerbated in cases where both states and dynamics are partially known.
arxiv
Heparin release from thermosensitive hydrogels [PDF]
, 1992 Thermosensitive hydrogels (TSH) were synthesized and investigated as heparin releasing polymers for the prevention of surface induced thrombosis. TSH were synthesized with N-isopropyl acrylamide (NiPAAm) copolymerized with butyl methacrylate (BMA ...
Bae, You Han +5 more
core +3 more sources
Regenerative Therapy, 2016 A heparin-modified thermoresponsive surface bound with heparin-binding epidermal growth factor-like growth factor (HB-EGF) was designed to allow creation of transferrable and functional hepatocyte sheets.
Yoshinori Arisaka +7 more
doaj +1 more source
Preparation and characterization of albumin-heparin microspheres [PDF]
, 1994 Albumin-heparin microspheres were prepared by a two-step process which involved the preparation of a soluble albumin-heparin conjugate, followed by formation of microspheres from this conjugate or by a double cross-linking technique involving both ...
Bae, Y.H. +7 more
core +2 more sources
Heparin Coating Technology in Cardiopulmonary Bypass
MATEC Web of Conferences, 2017 Heparin coating technology has become increasingly mature, which is conducive to the material of blood, biocompatibility proved very important, therefore, heparin coating technique has become a development cycle is very useful for in vitro selection of ...
Zhang Kun, Xue Rui, Shen Shuwei
doaj +1 more source
Advanced Biomedical Research, 2014 Background: Heparin has long been used to prevent thrombosis in the permanent central venous hemodialysis catheters (PermCath). Other alternatives for heparin with fewer side-effects have recently been considered.
Ali Akbar Beigi +3 more
doaj +1 more source
Heparin and air filters reduce embolic events caused by intra-arterial cerebral angiography - A prospective, randomized trial [PDF]
, 2004 Background-Intra-arterial cerebral angiography is associated with a low risk for neurological complications, but clinically silent ischemic events after angiography have been seen in a substantial number of patients.Methods and Results-In a prospective ...
Bartsch, AJ +8 more
core +1 more source