Results 71 to 80 of about 724,197 (388)

Heparin-Induced Hyperkalemia Assessment Utilizing the Naranjo Adverse Drug Reaction Probability Scale: A 40-Year Systematic Review

Pharmacy
Background: Adverse drug reactions have been reported as leading causes of morbidity and mortality. Unfractionated heparin- and low-molecular-weight heparin-induced hyperkalemia are side effects that have been reported in approximately 7 to 8% of heparin-
Divita Singh, Omnia A. E. A. Mesalhy, Michael J. Cawley   +2 more
doaj   +1 more source

Andexanet-Alfa-Associated Heparin Resistance in the Context of Hemorrhagic Stroke [PDF]

, 2022
Michael Müther, Wolfram Schwindt, Rolf M. Mesters, Jens Minnerup, Paul Stracke, Markus Holling, Heinz Wiendl, Walter Stummer   +7 more
openalex   +1 more source

Guidance for the practical management of the heparin anticoagulants in the treatment of venous thromboembolism

Journal of Thrombosis and Thrombolysis, 2016
Venous thromboembolism (VTE) is a serious and often fatal medical condition with an increasing incidence. Despite the changing landscape of VTE treatment with the introduction of the new direct oral anticoagulants many uncertainties remain regarding the ...
M. Smythe, Jennifer L. Priziola, P. Dobesh, Diane Wirth, A. Cuker, A. Wittkowsky   +5 more
semanticscholar   +1 more source

A Vascular Microphysiological Model of Lung Fibrosis Reveals That Myofibroblasts and IPF Patient‐Derived Fibroblasts Impair Angiogenesis and Vasculogenesis

Advanced Functional Materials, EarlyView.
A microphysiological lung fibrosis model recapitulates myofibroblast–vascular interactions. Induced myofibroblasts and patient‐derived IPF fibroblasts impair angiogenesis and increase vascular permeability via TGF‐β1–driven signaling. Pharmacological interventions with SB 431542 and VEGF supplementation restore vascular morphology and barrier function.
Elena Cambria, Adriana Blazeski, Eunkyung Clare Ko, Tran Thai, Shania Dantes, David A. Barbie, Sarah E. Shelton, Roger D. Kamm   +7 more
wiley   +1 more source

The use of heparin and heparin-like molecules in cancer treatment: a review

Cancer Treatment and Research Communications, 2020
Background: Heparin and heparin-like molecules have shown some promise in the treatment of several cancers. These molecules have roles in angiogenesis, cell proliferation, immune system modulation, cell migration, and cellular invasion.
Johnny Atallah, Hussein H. Khachfe, Juliett Berro, Hazem I. Assi   +3 more
doaj   +1 more source

The potential impact of Covid-19 on the capacity of routine laboratory tests to detect heparin-induced thrombocytopenia

Thrombosis Journal, 2022
In Covid-19, anticoagulation with heparin is often administered to prevent or treat thromboembolic events. Heparin-induced thrombocytopenia (HIT) is a severe complication of heparin treatment, caused by heparin-dependent, platelet activating anti ...
Dominik F. Draxler, Justine Brodard, Björn Zante, Stephan M. Jakob, Jan Wiegand, Johanna A. Kremer Hovinga, Anne Angelillo-Scherrer, Alicia Rovo   +7 more
doaj   +1 more source

Region‐to‐Region Unidirectional Connection In Vitro Brain Model for Studying Directional Propagation of Neuropathologies

Advanced Functional Materials, EarlyView.
A unidirectional cerebral organoid–organoid neural circuit is established using a microfluidic platform, enabling controlled directional propagation of electrical signals, neuroinflammatory cues, and neurodegenerative disease–related proteins between spatially separated organoids.
Kyeong Seob Hwang, Hui‐Wen Liu, Hyogeun Shin, Hyun Wook Kang, Minjin Kang, Jongbaeg Kim, Il‐Joo Cho, Nakwon Choi, Seok Chung, Hong Nam Kim   +9 more
wiley   +1 more source

Crude Heparin Preparations Unveil the Presence of Structurally Diverse Oversulfated Contaminants

Molecules, 2019
Nowadays, pharmaceutical heparin is purified from porcine and bovine intestinal mucosa. In the past decade there has been an ongoing concern about the safety of heparin, since in 2008, adverse effects associated with the presence of an oversulfated ...
Aline Mendes, Maria C. Z. Meneghetti, Marcelly Valle Palladino, Giselle Zenker Justo, Guilherme L. Sassaki, Jawed Fareed, Marcelo A. Lima, Helena B. Nader   +7 more
doaj   +1 more source

Heparinization of beta tricalcium phosphate: osteo-immunomodulatory effects [PDF]

, 2018
"This is the pre-peer reviewed version of the following article: A. Diez-Escudero, M. Espanol, M. Bonany, X. Lu, C. Persson, M.-P. Ginebra, Adv. Healthcare Mater.
Bonany Mariñosa, Mar, Díez Escudero, Anna, Español Pons, Montserrat, Ginebra Molins, Maria Pau, Persson, Cecilia   +4 more
core   +2 more sources

Adaptive 4D‐Printed Vascular Stents With Low‐Temperature‐Activated and Intelligent Deployment

Advanced Functional Materials, EarlyView.
Microarchitected coronary artery stents were fabricated using a polycaprolactone (PCL)‐based shape memory polymer (SMP) composite via projection micro‐stereolithography (PµSL) 4D printing. By incorporating diethyl phthalate (DEP) as a plasticizer, the thermal transition temperature (Ttran) was modulated to about 37°C, enabling rapid and autonomous ...
Yannan Li, Yifan Pan, Chikahiro Imashiro, Chaolun Xu, Jianxian He, Jingao Xu, Kewei Song, Ze Zhang, Chen Gao, Junbo Jiang, Runhuai Yang, Kayo Hirose, Shinjiro Umezu   +12 more
wiley   +1 more source