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Pathogenesis of Hepatic Encephalopathy [PDF]

Gastroenterology Research and Practice, 2012
Hepatic encephalopathy can be a serious complication of acute liver failure and chronic liver diseases, predominantly liver cirrhosis. Hyperammonemia plays the most important role in the pathogenesis of hepatic encephalopathy. The brain-blood barrier disturbances, changes in neurotransmission, neuroinflammation, oxidative stress, GABA-ergic or ...
Tomasz Mach, Irena Ciećko-Michalska, Agnieszka Slowik, Małgorzata Szczepanek   +3 more
openaire   +4 more sources

Trends in Characteristics, Mortality, and Other Outcomes of Patients With Newly Diagnosed Cirrhosis [PDF]

, 2019
Importance: Changes in the characteristics of patients with cirrhosis are likely to affect future outcomes and are important to understand in planning for the care of this population.
Chalasani, Naga, Desai, Archita, Ghabril, Marwan, Nephew, Lauren, Orman, Eric S., Patidar, Kavish, Roberts, Anna   +6 more
core   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Frailty Associated With Waitlist Mortality Independent of Ascites and Hepatic Encephalopathy in a Multicenter Study.

Gastroenterology, 2019
BACKGROUND & AIMS Frailty is associated with mortality in patients with cirrhosis. We measured frailty using 3 simple tests and calculated Liver Frailty Index (LFI) scores for patients at multiple ambulatory centers.
J. Lai, R. Rahimi, E. Verna, M. Kappus, M. Dunn, M. McAdams‐DeMarco, Christine E. Haugen, M. Volk, A. Duarte-Rojo, D. Ganger, J. O’Leary, J. Dodge, D. Ladner, D. Segev   +13 more
semanticscholar   +1 more source

The incidence of portal vein thrombosis at liver transplantation [PDF]

, 1992
The incidence of portal vein thrombosis was examined in 885 patients who received orthotopic liver transplantations for various end‐stage liver diseases between 1989 and 1990. The thrombosis was classified into four grades.
Iwatsuki, S, Nonami, T, Starzl, TE, Yokoyama, I   +3 more
core   +1 more source

Minimal Hepatic Encephalopathy [PDF]

Canadian Journal of Gastroenterology, 2013
Minimal hepatic encephalopathy (MHE) is the earliest form of hepatic encephalopathy and can affect up to 80% of cirrhotic patients. By definition, it has no obvious clinical manifestation and is characterized by neurocognitive impairment in attention, vigilance and integrative function.
Saumya Jayakumar, Laura M. Stinton
openaire   +3 more sources

Hepatic Encephalopathy and Melatonin

Antioxidants, 2022
Hepatic encephalopathy (HE) is a severe metabolic syndrome linked with acute/chronic hepatic disorders. HE is also a pernicious neuropsychiatric complication associated with cognitive decline, coma, and death. Limited therapies are available to treat HE, which is formidable to oversee in the clinic.
Archana Arjunan, Dhiraj Kumar Sah, Young Do Jung, Juhyun Song   +3 more
openaire   +3 more sources

Clinical features of alcoholic hepatitis in latinos and caucasians: A single center experience. [PDF]

, 2017
AimTo study differences of presentation, management, and prognosis of alcoholic hepatitis in Latinos compared to Caucasians.MethodsWe retrospectively screened 876 charts of Caucasian and Latino patients who were evaluated at University of California ...
Durbin-Johnson, Blythe, Halsted, Charles H, Medici, Valentina, Pinon-Gutierrez, Rogelio   +3 more
core   +1 more source

Functional Hydrogel for Modulating Lipid Droplets and Neuroinflammation in Head Injury

Advanced Functional Materials, EarlyView.
After TBI, elevated cholesterol levels in activated microglia lead to the accumulation of cholesterol esters in lipid droplets, exacerbating neuroinflammation. A β‐cyclodextrin‐conjugated GelMA (βCD‐GelMA) hydrogel is developed to promotes cholesterol efflux and reduces LDL influx, thereby alleviating intracellular cholesterol and lipid droplet buildup.
Feixiang Chen, Yvonne Shen, Yutong Shao, Tenghuan Ge, Haowen Qiao, Shangzhou Xia, Yafei Qu, Yuanpu Chiu, Ying Qin, Zhen Zhao   +9 more
wiley   +1 more source

Muscle Alterations Are Associated With Minimal and Overt Hepatic Encephalopathy in Patients With Liver Cirrhosis

Hepatology, 2019
Muscle alterations (myosteatosis and sarcopenia) are frequent in cirrhosis and related to some complications including overt hepatic encephalopathy (HE).
S. Nardelli, B. Lattanzi, M. Merli, A. Farcomeni, S. Gioia, L. Ridola, O. Riggio   +6 more
semanticscholar   +1 more source