Results 21 to 30 of about 180,751 (262)

Autoimmune Hepatitis and Fibrosis

Journal of Clinical Medicine, 2023
Autoimmune hepatitis (AIH) is a chronic immune-inflammatory disease of the liver, generally considered a rare condition. The clinical manifestation is extremely varied and can range from paucisymptomatic forms to severe hepatitis. Chronic liver damage causes activation of hepatic and inflammatory cells leading to inflammation and oxidative stress ...
Rinaldo Pellicano, Arianna Ferro, Francesca Cicerchia, Simone Mattivi, Sharmila Fagoonee, Marilena Durazzo   +5 more
openaire   +2 more sources

A Selective PPARγ Modulator Reduces Hepatic Fibrosis

Biology, 2020
Hepatic fibrosis is the accumulation of excess collagen as a result of chronic liver injury. If left unabated, hepatic fibrosis can lead to the disruption of the liver architecture, portal hypertension, and increased risk of progression to cirrhosis and ...
Benita L. McVicker, Frederick G. Hamel, Ronda L. Simpson, Robert G. Bennett   +3 more
doaj   +1 more source

Safe standard remnant liver volume after hepatectomy in HCC patients in different stages of hepatic fibrosis

BMC Surgery, 2021
Background To determine the standard remnant liver volume (SRLV) threshold to avoid postoperative hepatic insufficiency inpatients in different stages of hepatic fibrosis who undergo right hemi-hepatectomy.
Zhiming Zhang, Gaoxiong Ouyang, Peng Wang, Yuan Ren, Yukai Liu, Jun Chen, Yumei Zhang, Jianyong Liu, Lequn Li   +8 more
doaj   +1 more source

Role of PNPLA3 in the Assessment and Monitoring of Hepatic Steatosis and Fibrosis in Patients with Chronic Hepatitis C Infection Who Achieved a Sustained Virologic Response

Medicina, 2021
Background and Objectives: Hepatic diseases are an important public health problem. All patients with chronic hepatitis C virus (HCV) infection receive treatment, regardless of hepatic fibrosis severity.
Oana Irina Gavril, Lidia Iuliana Arhire, Otilia Gavrilescu, Mihaela Dranga, Oana Barboi, Radu Sebastian Gavril, Roxana Popescu, Cristina Cijevschi Prelipcean, Anca-Victorita Trifan, Catalina Mihai   +9 more
doaj   +1 more source

Hepatic Fibrosis in Dogs [PDF]

Journal of Veterinary Internal Medicine, 2017
Hepatic fibrosis is commonly diagnosed in dogs, often as a sequela to chronic hepatitis (CH). The development of fibrosis is a crucial event in the progression of hepatic disease that is of prognostic value. The pathophysiology of hepatic fibrosis in human patients and rodent models has been studied extensively.
V.M. Eulenberg, J.A. Lidbury
openaire   +2 more sources

GATA4 induces liver fibrosis regression by deactivating hepatic stellate cells

JCI Insight, 2021
In response to liver injury, hepatic stellate cells activate and acquire proliferative and contractile features. The regression of liver fibrosis appears to involve the clearance of activated hepatic stellate cells, either by apoptosis or by reversion ...
Noelia Arroyo, Laura Villamayor, Irene Díaz, Rita Carmona, Mireia Ramos-Rodríguez, Ramón Muñoz-Chápuli, Lorenzo Pasquali, Miguel G. Toscano, Franz Martín, David A. Cano, Anabel Rojas   +10 more
doaj   +1 more source

The Combination of Schisandrol B and Wedelolactone Synergistically Reverses Hepatic Fibrosis Via Modulating Multiple Signaling Pathways in Mice

Frontiers in Pharmacology, 2021
Hepatic fibrosis represents an important event in the progression of chronic liver injury to cirrhosis, and is characterized by excessive extracellular matrix proteins aggregation.
Yongqiang Ai, Wei Shi, Xiaobin Zuo, Xiaoming Sun, Yuanyuan Chen, Zhilei Wang, Ruisheng Li, Xueai Song, Wenzhang Dai, Wenqing Mu, Kaixin Ding, Zhiyong Li, Qiang Li, Xiaohe Xiao, Xiaohe Xiao, Xiaoyan Zhan, Xiaoyan Zhan, Zhaofang Bai, Zhaofang Bai   +18 more
doaj   +1 more source

Exploration of new therapeutic targets for viral hepatic fibrosis, alcoholic hepatic fibrosis, and non-alcoholic hepatic fibrosis

Annals of Translational Medicine, 2022
Hepatic fibrosis is a widespread disease worldwide. Millions of people lose their lives due to hepatic fibrosis every year. The main causes of hepatic fibrosis include viral infection, alcoholism, and obesity. Many studies have been conducted on the single factors that cause hepatic fibrosis; however, no studies have examined whether hepatic fibrosis ...
Wang, Xiaoling, Wang, Ying, Li, Xuewei, Qin, Shuo, Xu, Jun, Xie, Jun   +5 more
openaire   +2 more sources

The roles of lncRNA in hepatic fibrosis

Cell & Bioscience, 2018
Increasing evidence indicates that long non-coding RNAs (lncRNAs) regulate gene or protein expression; however, their function in the progression of hepatic fibrosis remains unclear.
Hu Peng, Lin-Yan Wan, Jia-Jie Liang, Yan-Qiong Zhang, Wen-Bing Ai, Jiang-Feng Wu   +5 more
doaj   +1 more source

Prediction of hepatic metastasis and relapse in colorectal cancers based on concordance analyses with liver fibrosis scores

Clinical and Translational Medicine, 2020
Background Liver fibrosis, resulted from several liver diseases, are increasing up to 25% in population in global. It remains undetermined how much impact liver fibrosis have on the development of hepatic metastasis and relapse in colorectal cancer (CRC).
Xiang Hu, Audrey Marietta, Wei-Xing Dai, Ya-Qi Li, Xiao-ji Ma, Long Zhang, San-Jun Cai, Jun-Jie Peng   +7 more
doaj   +1 more source