Results 91 to 100 of about 205,561 (359)

Cellular deconvolution of GTEx tissues powers discovery of disease and cell-type associated regulatory variants. [PDF]

, 2020
The Genotype-Tissue Expression (GTEx) resource has provided insights into the regulatory impact of genetic variation on gene expression across human tissues; however, thus far has not considered how variation acts at the resolution of the different cell ...
D'Antonio, Matteo, D'Antonio-Chronowska, Agnieszka, Donovan, Margaret KR, Frazer, Kelly A   +3 more
core  

Mesenchymal Stem Cell‐Inspired Microneedle Platform for NIR‐responsive Immunomodulation and Accelerated Chronic Wound Healing

Advanced Materials, EarlyView.
The research demonstrates a Mesenchymal Stem Cell‐inspired microneedle platform (MSCi@MN) that addresses chronic diabetic wounds by combining MSC‐derived extracellular nanovesicles (NV)–DNA conjugates in microneedle tips with photothermal MXene in the patch layer.
Chan Ho Moon, Hee Gyeong Ko, Hyun Lee, Seojoon Bang, Hyeong Seok Kang, Ju Yeong Gwon, Jong Hwa Seo, Nayoung Lee, So Won Jeon, Yun‐A Kim, Jong Sang Yoon, Kyung‐Yup Cha, Min‐Ho Kang, Dong Yun Lee, Soo‐Hong Lee, Gi Doo Cha, Kisuk Yang, Donghyun Lim, Heemin Kang, Su Ryon Shin, Han Young Kim, Hyun‐Do Jung   +21 more
wiley   +1 more source

Levels of hepatic Th17 cells and regulatory T cells upregulated by hepatic stellate cells in advanced HBV-related liver fibrosis

Journal of Translational Medicine, 2017
Background Liver fibrosis which mainly occurs upon chronic hepatitis virus infection potentially leads to portal hypertension, hepatic failure and hepatocellular carcinoma.
Xiaoyan Li, Yujie Su, Xuefeng Hua, Chan Xie, Jing Liu, Yuehua Huang, Liang Zhou, Min Zhang, Xu Li, Zhiliang Gao   +9 more
doaj   +1 more source

MicroRNA-214 promotes hepatic stellate cell activation and liver fibrosis by suppressing Sufu expression

Cell Death and Disease, 2018
MicroRNAs (miRNAs) have been demonstrated to modulate cellular processes in the liver. However, the role of miRNAs in liver fibrosis is poorly understood.
Liping Ma, Xiaoxue Yang, Rong Wei, Tinghong Ye, Jiankang Zhou, Mao-yao Wen, R. Men, Ping Li, Biao Dong, Lunxu Liu, Xianghui Fu, Heng Xu, R. Aqeilan, Yu‐quan Wei, Li Yang, Yong Peng   +15 more
semanticscholar   +1 more source

Immune and Inflammatory Pathways in Non-Alcoholic Steatohepatitis (NASH). An update [PDF]

, 2019
Non-alcoholic steatohepatitis (NASH), also known as fatty liver disease (FLD), is a major public health problem. It is considered to be the hepatic manifestation of the metabolic syndrome.
Breaban, Iulia, Coste, Sorina Cezara, Cozma, Angela, Negrean, Vasile, Orasan, Olga Hilda, Popovici, Ionela, Procopciuc, Lucia Maria, Sampelean, Dorel, Sitar Taut, Adela, Stefan, Andreea Maria, Tarmure Sarlea, Simina   +10 more
core   +1 more source

Matrix metalloproteinases in liver injury, repair and fibrosis. [PDF]

, 2015
The liver is a large highly vascularized organ with a central function in metabolic homeostasis, detoxification, and immunity. Due to its roles, the liver is frequently exposed to various insults which can cause cell death and hepatic dysfunction ...
Baber, John, Coito, Ana J, Duarte, Sergio, Fujii, Takehiro   +3 more
core   +1 more source

MEMS‐Based Magnetoelectric Antennas for Wireless Power Transmission in Brain‐Implantable Devices

Advanced Materials Technologies, EarlyView.
Magnetoelectric (ME) antennas allow the minimization of the invasiveness of brain implantable devices, via powering wirelessly systems able to actuate neural tissue. In order to achieve the necessary power efficiency transmission, the choice of the materials and the system assembly is vital.
Laura Mazón‐Maldonado, Jungang Zhang, María Cerezo‐Sánchez, Mahdieh Shojaei Baghini, Roghaieh Parvizi, Hadi Heidari   +5 more
wiley   +1 more source

Focal Adhesion Kinase Regulates Hepatic Stellate Cell Activation and Liver Fibrosis

Scientific Reports, 2017
Understanding the underlying molecular mechanisms of liver fibrosis is important to develop effective therapy. Herein, we show that focal-adhesion-kinse (FAK) plays a key role in promoting hepatic stellate cells (HSCs) activation in vitro and liver ...
Xue-ke Zhao, Lei Yu, M. Cheng, P. Che, Yinfeng Lu, Quan Zhang, M. Mu, Hong Li, Lili Zhu, Juan-juan Zhu, Meng Hu, Po Li, Yue-Dong Liang, Xin-hua Luo, Yiju Cheng, Zhi-xiang Xu, Q. Ding   +16 more
semanticscholar   +1 more source

Hepatic stellate cells induce an inflammatory phenotype in Kupffer cells via the release of extracellular vesicles [PDF]

, 2023
Yana Geng, Junyu Wang, Sandra Serna Salas, Alejandra Hernández Villanueva, Manon Buist‐Homan, Marco Arrese, Peter Olinga, Hans Blokzijl, Han Moshage   +8 more
openalex   +1 more source

Induction of microRNA-214-5p in human and rodent liver fibrosis [PDF]

, 2012
BACKGROUND: miRNAs are non-coding RNAs that regulate gene expression in a wide range of biological contexts, including a variety of diseases. The present study clarified the role of miR-214-5p in hepatic fibrogenesis using human clinical tissue samples ...
Hiroyuki Motoyama, Katsutoshi Yoshizato, Kazuo Ikeda, Masaru Enomoto, Masashi Iizuka, Norifumi Kawada, Tomohiro Ogawa   +6 more
core   +1 more source