Results 111 to 120 of about 223,054 (350)

Oxidative stress: new insights on the association of nonalcoholic fatty liver disease and atherosclerosis [PDF]

, 2015
Non-alcoholic fatty liver disease (NAFLD) represents the most common and emerging chronic liver disease worldwide. It includes a wide spectrum of liver diseases ranging from simple fatty liver to non-alcoholic steatohepatitis (NASH), which may progress ...
Albanese, Fabiana, Angelico, Francesco, Baratta, Francesco, DEL BEN, Maria, Pastori, Daniele, Perri, Ludovica, Polimeni, Licia, Violi, Francesco   +7 more
core   +1 more source

Marburg Virus Glycoprotein Is a Remarkable Virulent Factor Linked to Hemorrhagic Pathology: Evidence from Multimodal Experimental Systems

Advanced Science, EarlyView.
By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao, Hang Liu, Yanfeng Yao, Wei Deng, Jiawen Sun, Zhenyu Kang, Ashaq Ali, Chao Shan, Zhiming Yuan, Fei Deng, Hualin Wang, Yun‐Jia Ning   +11 more
wiley   +1 more source

Multi-lineage hepatic organoids reveal toxic exosome mediated indirect hepatotoxicity

Nature Communications
Indirect hepatotoxicity remains a major challenge in drug development because of limited evaluation tools and mechanistic insight. Here, we construct three-dimensional multi-lineage hepatic organoids comprising five liver cell types derived from human ...
Lei Sun, Yuying Zhang, Yudi Niu, He Yang, Lyu Zhou, Xiaodong Jia, Yihan Chen, Zhiqiang Liu, Tiantian Wang, Kaini Liang, Dongdong Fan, Sida Ling, Zhen Zeng, Yanan Du   +13 more
doaj   +1 more source

ADAMTS13 is expressed in hepatic stellate cells [PDF]

Laboratory Investigation, 2005
ADAMTS13 is a circulating zinc metalloprotease that cleaves the hemostatic glycoprotein von Willebrand factor (VWF) in a shear-dependent manner. Deficiency in ADAMTS13, owing to genetic mutations or autoimmune inhibitors, causes thrombotic thrombocytopenic purpura (TPP). Northern blot analysis has shown that ADAMTS13 is expressed primarily in the liver.
Wenhua, Zhou, Mari, Inada, Tai-Ping, Lee, Daniel, Benten, Sergey, Lyubsky, Eric E, Bouhassira, Sanjeev, Gupta, Han-Mou, Tsai   +7 more
openaire   +2 more sources

Hemojuvelin-Neogenin Interaction Is Required for Bone Morphogenic Protein-4-induced Hepcidin Expression [PDF]

, 2009
Hemojuvelin (HJV) is a glycosylphosphatidylinositol-linked protein and binds both bone morphogenic proteins (BMPs) and neogenin. Cellular HJV acts as a BMP co-receptor to enhance the transcription of hepcidin, a key iron regulatory hormone secreted ...
An-Sheng Zhang, Andriopoulos, Babitt, Babitt, Babitt, Camaschella, Caroline A. Enns, Conrad, Davies, De Domenico, De Gobbi, Du, Fan Yang, Feng, Feng, Finberg, Frazer, Goldschneider, Hentze, Hidekazu Tsukamoto, Huang, Jiaohong Wang, Kautz, Kuns-Hashimoto, Lin, Lin, Luxon, Matsunaga, Matsunaga, Maxson, Meynard, Niederkofler, Papanikolaou, Pigeon, Samad, Schaffar, Silvestri, Wang, Xia, Xia, Yang, Zhang, Zhang, Zhang, Zhang   +44 more
core   +4 more sources

Size‐Modulated Mesoderm‐Endoderm Divergence and Myocardial Cavitation in Micropatterned Cardioids

Advanced Science, EarlyView.
Micropatterned cardioids, CRISPR‐engineered reporter hiPSCs, deep‐tissue imaging, and single‐cell RNA sequencing are integrated to model mesoderm‐endoderm co‐development. Heart‐foregut crosstalk promotes single large cavitation inside cardioids, resembling early heart chamber formation. ABSTRACT The human heart, originating from the splanchnic mesoderm,
Plansky Hoang, David W. McKellar, Andrew Kowalczewski, Nhu Y. Mai, Meng Chai, Xiaojun L. Lian, Yi Zheng, Jeffrey Amack, Nathan Tucker, Iwijn De Vlaminck, Huaxiao Yang, Benjamin D. Cosgrove, Zhen Ma   +12 more
wiley   +1 more source

MicroRNA-214 promotes hepatic stellate cell activation and liver fibrosis by suppressing Sufu expression

Cell Death and Disease, 2018
MicroRNAs (miRNAs) have been demonstrated to modulate cellular processes in the liver. However, the role of miRNAs in liver fibrosis is poorly understood.
Liping Ma, Xiaoxue Yang, Rong Wei, Tinghong Ye, Jiankang Zhou, Mao-yao Wen, R. Men, Ping Li, Biao Dong, Lunxu Liu, Xianghui Fu, Heng Xu, R. Aqeilan, Yu‐quan Wei, Li Yang, Yong Peng   +15 more
semanticscholar   +1 more source

Contribution of galectin-1, a glycan-binding protein, to gastrointestinal tumor progression [PDF]

, 2017
Gastrointestinal cancer is a group of tumors that affect multiple sites of the digestive system, including the stomach, liver, colon and pancreas. These cancers are very aggressive and rapidly metastasize, thus identifying effective targets is crucial ...
Bacigalupo, Maria Lorena, Carabias, Pablo, Troncoso, María Fernanda   +2 more
core   +1 more source

Hepatocyte PIEZO1 Negatively Regulates Lipogenesis and Ameliorates MASLD by Sensing Membrane Tension and Activating AMPK

Advanced Science, EarlyView.
Hepatocytes are subjected to increased membrane tension along with lipid accumulation. Loss of PIEZO1 exacerbates high‐fat diet‐induced MASLD in mice. Activation of PIEZO1 alleviates high‐fat diet‐induced MASLD in mice. PIEZO1 negatively regulates de novo lipogenesis through activation of CaMKK2‐AMPK pathway. ABSTRACT Liver is a central organ for lipid
Hui Chen, Qimeng Wang, Ke Yang, Qinghai Lian, Xuyun Peng, Zhiyong Gong, Xinyi Zhao, Yong Wu, Tian Tao, Siqi Xu, Yifan Chen, Xiaoyan Tang, Jinghui Guo, Geyang Xu, Qi Zhang   +14 more
wiley   +1 more source

Focal Adhesion Kinase Regulates Hepatic Stellate Cell Activation and Liver Fibrosis

Scientific Reports, 2017
Understanding the underlying molecular mechanisms of liver fibrosis is important to develop effective therapy. Herein, we show that focal-adhesion-kinse (FAK) plays a key role in promoting hepatic stellate cells (HSCs) activation in vitro and liver ...
Xue-ke Zhao, Lei Yu, M. Cheng, P. Che, Yinfeng Lu, Quan Zhang, M. Mu, Hong Li, Lili Zhu, Juan-juan Zhu, Meng Hu, Po Li, Yue-Dong Liang, Xin-hua Luo, Yiju Cheng, Zhi-xiang Xu, Q. Ding   +16 more
semanticscholar   +1 more source