Results 191 to 200 of about 43,780 (265)

Beyond Gut Modulation: A Critical Review of the Therapeutic Potential, Safety, and Clinical Prospects of Natural Polysaccharides for IBD

Food Safety and Health, EarlyView.
In this review, we critically summarized the application of natural polysaccharides (NPs) for the treatment of IBD. This approach combines, in a unique way (right), the basic structure–activity relationships of NPs from different origins (left) with their multipronged mode of action, which involves modulation of the gut microbiota and other ...
Felix Danso, A. M. Abd El‐Aty, Kwaku Amoah, Xianghong Ju   +3 more
wiley   +1 more source

Macrophage β-catenin-Ihh axis induces hepatic stellate cell activation and fibrosis in metabolic dysfunction-associated steatohepatitis. [PDF]

Inflamm Res
Zhang R, Yang Y, Xiao F, He Y, Chai Y, Qiu J, Zhu Q, Sun W, Chen M, Xu Z.   +9 more
europepmc   +1 more source

LXRα and PPARα Mediated Hepatic Lipid Metabolic Disruption Induced by the UV Filter EHMC in 2D and 3D HepaRG Cell Models

Food Safety and Health, EarlyView.
Dietary UV filter EHMC induces hepatic steatosis in HepaRG cells at noncytotoxic concentrations. Mechanistically, EHMC binds nuclear receptors (LXRα, PPARα), upregulating SREBP‐1 to accelerate fatty acid synthesis. These findings highlight the potential metabolic toxicity of widespread EHMC exposure through food sources.
Shanglin Yang, Na Li, Yingnan Han, Mei Ma   +3 more
wiley   +1 more source

Mechanisms and therapeutic strategies of bidirectional crosstalk between hepatic stellate cell-derived cancer-associated fibroblasts and T cells in immune evasion and therapeutic resistance of hepatocellular carcinoma. [PDF]

Front Immunol
Pan K, Ma C.
europepmc   +1 more source

Safety and Metabolic Effects of Withania somnifera Seed Extract and Powder in Rats: Insights From DPP‐4 Molecular Docking

Food Safety and Health, EarlyView.
Withania somnifera seed extract and powder improved metabolic parameters in rats, particularly at higher extract doses, without evident hepatic, renal, hematological, or histopathological toxicity. Molecular docking further predicted strong DPP‐4 inhibitory potential of withanone, supporting the antidiabetic potential of W. somnifera seeds.
Muhammad Usman Khalid, Muhammad Waqar, Muhammad Tauseef Sultan, Muhammad Maaz, Ahmad Mujtaba Noman, Hassan Raza, Muhammad Israr, Djilali Benabdelmoumene, Abdifetah Ibrahim Omar   +8 more
wiley   +1 more source

RUNX1-mediated repression of miR-24 promotes hepatic stellate cell activation and liver fibrosis by targeting the ALK4/Smad3 signaling pathway. [PDF]

Front Genet
Wang Z, Song M, Zhao Y, Li J, Xia L, Wang F, Yang C.   +6 more
europepmc   +1 more source

Citrus Essential Oils in Food Safety and Health: Advances in AI‐Assisted Authentication, Antimicrobial Applications, Sustainable Extraction, and Regulatory Translation

Food Safety and Health, EarlyView.
Citrus essential oils combine sustainable extraction, AI‐assisted authentication, multi‐omics profiling, antimicrobial activity, and regulatory safety to enhance food quality, detect adulteration, and promote consumer health, and support intelligent, sustainable food systems through innovative industrial applications and circular bioeconomy strategies.
Md. Hassan Bin Nabi, Liza Akter, Yusuf Chowdhury, Mohima Akther Any, Nazmul Islam, Erni Sofia Murtini, Nurul Huda, Wahidu Zzaman   +7 more
wiley   +1 more source

Hepatic stellate cell derived lipid droplets drive protumoral M2 macrophage polarization in hepatocellular carcinoma. [PDF]

Discov Oncol
You Y, Huang S, Xu J, Li Q, Wang Y, Zhan Z, Ye Y, Lan B, Wang X, Guo Z, Hu Q.   +10 more
europepmc   +1 more source

Treatment‐Related Adverse Events and Health‐Related Quality of Life Associated With Immune Checkpoint Inhibitor Treatment for Mucosal Head and Neck Squamous Cell Carcinoma: A Scoping Review

Head &Neck, EarlyView.
ABSTRACT Background Supportive care needs of patients receiving immune checkpoint inhibitors (ICIs) for head and neck squamous cell carcinoma (HNSCC) are ill‐defined. Hence, known treatment‐related adverse events (TRAEs) and health‐related quality of life (HRQoL) associated with ICI treatment for HNSCC were examined to inform future supportive care ...
N. D. O'Donnell, E. C. Ward, L. R. Wishart, R. Perera, C. Barrett, K. A. Edmiston, E. Mitchell, A. Pigott, R. Pitt, K. Russell, B. A. Chan, R. Ladwa   +11 more
wiley   +1 more source

Abelmoschus manihot Polysaccharides Target the AMPK/Nrf2/HO-1 Signalling Pathway to Inhibit Macrophage M1 Polarisation and Hepatic Stellate Cell Activation Improving Liver Fibrosis in Mice. [PDF]

J Cell Mol Med
Li S, Chang Z, Liu J, Lu H.
europepmc   +1 more source