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Targeting SPHK1 by 8-HETrE attenuates MASH-Driven fibrosis via restoration of hepatic stellate cell mitochondrial dynamics. [PDF]

Cell Biol Toxicol
Chen S, Li J, Xu K, Wen J, Zhang F, Zhuge Y, Wang L, Yi Y, Zhang H, Zhang W.   +9 more
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Mechanisms of hepatic stellate cell activation

Nature Reviews Gastroenterology and Hepatology, 2017
Hepatic fibrosis is a dynamic process characterized by the net accumulation of extracellular matrix resulting from chronic liver injury of any aetiology, including viral infection, alcoholic liver disease and NASH. Activation of hepatic stellate cells (HSCs) - transdifferentiation of quiescent, vitamin-A-storing cells into proliferative, fibrogenic ...
Scott L. Friedman
exaly   +3 more sources

Cryopreservation of hepatic stellate cells

Journal of Hepatology, 2006
Isolated rat hepatic stellate cells (HSC) are taken as a valuable in vitro model to study hepatic fibrogenesis, biotransformation of pharmaceutics, gene expression, transcription factors controlling HSC behaviour, and for the establishment of long-term cultures. Consequently, methods for the isolation and maintenance of HSC cultures are well documented.
Svenja, Neyzen, Eddy, Van de Leur, Erawan, Borkham-Kamphorst, Jens, Herrmann, Günter, Hollweg, Axel M, Gressner, Ralf, Weiskirchen   +6 more
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Hepatic stellate cell: A star cell in the liver

International Journal of Biochemistry and Cell Biology, 2009
Hepatic stellate cells represent a highly versatile cytotype that plays a significant role in liver development and differentiation, regeneration, xenobiotic response, immunoregulation, control of hepatic blood flow and inflammatory reactions. Because of the wide panel of molecular intermediates they may produce and secrete, particularly after their ...
Luigi Atzori, Andrea Perra, Giuseppe POLI   +2 more
exaly   +4 more sources

Hepatic stellate cells in physiology and pathology

The Journal of Physiology, 2022
AbstractHepatic stellate cells (HSCs) comprise a minor cell population in the liver but serve numerous critical functions in the normal liver and in response to injury. HSCs are primarily known for their activation upon liver injury and for producing the collagen‐rich extracellular matrix in liver fibrosis.
Dakota R, Kamm, Kyle S, McCommis
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Transcriptional Regulation in Hepatic Stellate Cells

Seminars in Liver Disease, 2001
Modulation of gene expression through altered transcription regulates stellate cell behavior in normal liver and following hepatic injury. Transcription factors are generally classified according to conserved motifs within either the activation- or DNA- binding domains of the molecules.
F J, Eng, S L, Friedman
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Hepatic stellate cells and the reversal of fibrosis

Journal of Gastroenterology and Hepatology, 2006
AbstractHepatic fibrosis is an outcome of many chronic liver diseases, such as viral and autoimmune hepatitis, and of alcohol consumption and biliary obstruction. Prolonged liver injury results in hepatocyte damage, which triggers activation of hepatic stellate cells (HSC) and recruitment of inflammatory cells into the liver.
Tatiana, Kisseleva, David A, Brenner
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Studying Hepatic Stellate Cell Senescence

2023
Hepatic stellate cells (HSCs) are the key effector cells in liver fibrosis. They are the main producers of excessive amounts of extracellular matrix components during fibrogenesis and therefore a potential target for the treatment of liver fibrosis.
Sandra A, Serna-Salas, Abel A, Soto-Gámez, Zongmei, Wu, Myrthe, Klaver, Han, Moshage   +4 more
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Hepatic stellate cells

1998
The hepatic stellate cell (HSC) has emerged as a major regulator of normal liver homeostasis and growth, as well as a key effector in the hepatic fibrogenic response. In this chapter, we review the biological characteristics of the hepatic stellate cell, addressing historical perspectives, morphologic characteristics, methods of isolation, and their ...
Victor Ankoma-Sey, Scott L. Friedman
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Action of endothelins on hepatic stellate cells

Journal of Gastroenterology, 1995
To elucidate the role played by hepatic sinusoidal cells in the regulation of the circulatory status in the liver, the effect of endothelins (ETs) on primary-cultured stellate cells was examined. Kinetic analysis with 125I-labeled ET-1 revealed that stellate cells have ET receptors with a Kd value of 141 pM and a Bmax of 12.3 fmol/10(5) cells. ET-1, -2,
N, Kawada, T, Kuroki, K, Kobayashi, M, Inoue, K, Kaneda, K, Decker   +5 more
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