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Purification and Isolation of Hepatic Stellate Cells
2022Quiescent human hepatic stellate cells (HSCs) serve as important reservoirs of fat-soluble vitamins in the body, namely vitamin A. In an activated form, HSCs are the drivers of fibrosis following chronic liver injury. In non-alcoholic steatohepatitis (NASH) specifically, activated HSCs are drivers of induction and progression of fibrogenesis. Isolation
Sonia, Lele +3 more
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Signal transduction in hepatic stellate cells
Liver, 1998ABSTRACT— Hepatic stellate cells (HSC) are presently regarded as one of the key cell types involved in the progression of liver fibrosis and in the related pathophysiological and clinical complications. Following acute or chronic liver tissue damage, HSC undergo a process of activation towards a phenotype characterised by increased proliferation ...
PINZANI, MASSIMO +2 more
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Hepatic Stellate Cells and Liver Fibrosis
Comprehensive Physiology, 2013Abstract Hepatic stellate cells are resident perisinusoidal cells distributed throughout the liver, with a remarkable range of functions in normal and injured liver. Derived embryologically from septum transversum mesenchyme, their precursors include submesothelial cells that invade the liver parenchyma from the ...
Juan E, Puche +2 more
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Transcriptional regulation of hepatic stellate cells
Advanced Drug Delivery Reviews, 2009Hepatic stellate cell (HSC) activation is a process of cellular transdifferentiation in which, upon liver injury, the quiescent vitamin A storing perisinusoidal HSC is converted into a wound-healing myofibroblast and acquires potent pro-inflammatory and pro-fibrogenic activities.
Mann J, Mann DA
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1999
In 1876, von Kupffer discovered star-shaped cells in the hepatic lobules using the gold chloride method, and called them “Sternzellen” (stellate cells). In 1898, however, he misconstrued these cells as phagocytic cells. The original stellate cells were rediscovered in 1971.
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In 1876, von Kupffer discovered star-shaped cells in the hepatic lobules using the gold chloride method, and called them “Sternzellen” (stellate cells). In 1898, however, he misconstrued these cells as phagocytic cells. The original stellate cells were rediscovered in 1971.
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Hepatic and pancreatic stellate cells in focus
bchm, 2009Abstract Stellate cells are vitamin A-storing cells of liver and pancreas and have been described in all vertebrates ranging from lampreys (primitive fish) to humans, demonstrating their major importance. This cell type is thought to contribute to fibrosis, a condition characterized by an excess deposition of extracellular matrix ...
Claus, Kordes +2 more
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Structure and function of hepatic stellate cells
Medical Electron Microscopy, 2004Hepatic stellate cells (vitamin A-storing cells, lipocytes, interstitial cells, fat-storing cells, Ito cells) exist in the space between parenchymal cells and sinusoidal endothelial cells of the hepatic lobule and store 80% of retinoids in the whole body as retinyl palmitate in lipid droplets in the cytoplasm.
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2001
Carl Kupffer, by the use of a gold chloride staining method, detected in mammalian livers a population of stellate-shaped cells that were located perisinusoidally, always attached to the sinusoidal capillaries and also to the parenchymal cells (Kupffer 1876, cited by Wake 1980).
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Carl Kupffer, by the use of a gold chloride staining method, detected in mammalian livers a population of stellate-shaped cells that were located perisinusoidally, always attached to the sinusoidal capillaries and also to the parenchymal cells (Kupffer 1876, cited by Wake 1980).
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Hepatic Stellate Cells in Liver Tumor
2020Hepatocellular carcinoma and intrahepatic cholangiocarcinoma are the most common types of primary liver cancers. Moreover, the liver is the second most frequently involved organ in cancer metastasis after lymph nodes. The tumor microenvironment is crucial for the development of both primary and secondary liver cancers.
Hidenori, Shiraha +2 more
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Modulation of hepatic stellate cells and reversibility of hepatic fibrosis
Experimental Cell Research, 2017Hepatic fibrosis (HF) is the pathological component of a variety of chronic liver diseases. Hepatic stellate cells (HSC) are the main collagen-producing cells in the liver and their activation promotes HF. If HSC activation and proliferation can be inhibited, HF occurrence and development can theoretically be reduced and even reversed.
Yu, Huang, Xin, Deng, Jian, Liang
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