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P311 modulates hepatic stellate cells migration
Liver International, 2014AbstractBackground & AimsLiver fibrosis is induced by the accumulation of extracellular matrix, deposited mainly by activated hepatic stellate cells (HSCs). One key characteristic of stellate cell activation is the directional migration to the site of injury during the wound‐healing process.
Stradiot, Leslie +4 more
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Adipogenic Phenotype of Hepatic Stellate Cells
Alcoholism: Clinical and Experimental Research, 2005Abstract: Transdifferentiation of hepatic stellate cells (HSC) constitutes a major cellular event in the genesis of alcoholic liver fibrosis and cirrhosis and molecular mechanisms underlying this process is incompletely understood. Our laboratory proposed several years ago that HSC quiescence requires the transcriptional program known to be integral ...
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Cytokine Receptors and Signaling in Hepatic Stellate Cells
Seminars in Liver Disease, 2001Following acute or chronic liver tissue damage, hepatic stellate cells (HSCs) undergo a process of activation toward a phenotype characterized by increased proliferation, motility, contractility, and synthesis of extracellular matrix components. Activation of HSCs is regulated by several soluble factors, including growth factors, cytokines, chemokines,
PINZANI, MASSIMO, MARRA, FABIO
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Hepatic stellate cells—the pericytes in the liver
Pflügers Archiv - European Journal of Physiology, 2013Hepatic stellate cells (HSCs) are pericytes of liver in the space between parenchymal cells and sinusoidal endothelial cells of the hepatic lobule. HSCs comprise specialized functions such as vitamin A storage, hemodynamic functions, support of liver regeneration, and immunoregulation.
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Isolation and Culture of Hepatic Stellate Cells
2005Hepatic stellate cells (HSCs) are routinely prepared by collagenase/pronase digestion of liver using a perfusion system and subsequent fractionation of the heterogeneous cell suspension on continuous density gradients made out of Nycodenz, metrizamide, stractan, or percoll.
Ralf, Weiskirchen, Axel M, Gressner
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Extra- and Intra-Cellular Mechanisms of Hepatic Stellate Cell Activation
Biomedicines, 2021Changyong Li
exaly