Results 11 to 20 of about 210,456 (335)

β-arrestin1 activates hepatic stellate cells to promote liver fibrosis via activating p38 signaling pathway [PDF]

Xin yixue, 2023
Objective To investigate the role ofβ-arrestin1 （ARRB1） in liver fibrosis and elucidate the mechanism of hepatic stellate cell activation induced by ARRB1/p38 signaling pathway to promote liver fibrosis.
Xia Yanhao, Liu Huiling, Jiang Jie, Wu Bin
doaj   +1 more source

CD8+ tissue-resident memory T cells promote liver fibrosis resolution by inducing apoptosis of hepatic stellate cells

Nature Communications, 2021
Non-alcoholic steatohepatitis (NASH) is a leading cause of chronic liver disease that can progress to liver fibrosis. Recent clinical advance suggests a reversibility of liver fibrosis, but the cellular and molecular mechanisms underlying NASH resolution
Yuzo Koda, Toshiaki Teratani, Po-sung Chu, Yuya Hagihara, Y. Mikami, Yosuke Harada, Hanako Tsujikawa, K. Miyamoto, Takahiro Suzuki, N. Taniki, T. Sujino, M. Sakamoto, T. Kanai, N. Nakamoto   +13 more
semanticscholar   +1 more source

Histone H3K27 methyltransferase EZH2 and demethylase JMJD3 regulate hepatic stellate cells activation and liver fibrosis

Theranostics, 2021
Rationale: As the central hallmark of liver fibrosis, transdifferentiation of hepatic stellate cells (HSCs), the predominant contributor to fibrogenic hepatic myofibroblast responsible for extracellular matrix (ECM) deposition, is characterized with ...
Yan Jiang, Chan Xiang, F. Zhong, Yang Zhang, Liyan Wang, Yuanyuan Zhao, Jiucun Wang, Chen Ding, Li Jin, F. He, Haijian Wang   +10 more
semanticscholar   +1 more source

Pathophysiological mechanisms of hepatic stellate cells activation in liver fibrosis

World Journal of Clinical Cases, 2022
Liver fibrosis is a complex pathological process controlled by a variety of cells, mediators and signaling pathways. Hepatic stellate cells play a central role in the development of liver fibrosis. In chronic liver disease, hepatic stellate cells undergo
D. Garbuzenko
semanticscholar   +1 more source

[Retracted] Peritumoral activated hepatic stellate cells are associated with hepatic recurrence for resectable colorectal adenocarcinoma liver metastasis following resection. [PDF]

Oncol Lett
Deng L, Li T, Liao Y, Liu S, Xie Z, Huang Z, Dai H, Li J, Lei X.   +8 more
europepmc   +2 more sources

EP3 enhances adhesion and cytotoxicity of NK cells toward hepatic stellate cells in a murine liver fibrosis model

Journal of Experimental Medicine, 2022
Tao et al. describe that activation of E-prostanoid 3 receptor (EP3) ameliorates injury-induced liver fibrosis through promoting NK cell adhesion and killing of activated hepatic stellate cells in mice, indicating that EP3 may serve as a potential ...
Xixi Tao, Rui Zhang, Ronglu Du, Tingting Yu, H. Yang, Jiwen Li, Yuhong Wang, Qian Liu, Shengkai Zuo, Xi Wang, M. Lazarus, Lu Zhou, Bangmao Wang, Yingjia Yu, Yujun Shen   +14 more
semanticscholar   +1 more source

Hydrostatic pressure induces profibrotic properties in hepatic stellate cells via the RhoA/ROCK signaling pathway

FEBS Open Bio, 2022
Elevated interstitial fluid hydrostatic pressure is commonly observed in diseased livers. We herein examined the hypothesis that hydrostatic pressure induces hepatic stellate cells to acquire profibrotic properties under pathological conditions.
Zisheng Huang, Mahmoud Osman Khalifa, Weili Gu, Tao‐Sheng Li   +3 more
doaj   +1 more source

Inhibiting xCT/SLC7A11 induces ferroptosis of myofibroblastic hepatic stellate cells but exacerbates chronic liver injury

Liver international (Print), 2021
The outcome of liver injury is dictated by factors that control the accumulation of myofibroblastic (activated) hepatic stellate cells (MF‐HSCs) but therapies that specifically block this process have not been discovered. We evaluated the hypothesis that
Kuo Du, Seh-hoon Oh, R. Dutta, Tianai Sun, Wen-Hsuan Yang, J. Chi, A. Diehl   +6 more
semanticscholar   +1 more source

Liver fibrosis is driven by protease‐activated receptor‐1 expressed by hepatic stellate cells in experimental chronic liver injury

Research and Practice in Thrombosis and Haemostasis, 2020
Background Blood coagulation protease activity is proposed to drive hepatic fibrosis through activation of protease‐activated receptors (PARs). Whole‐body PAR‐1 deficiency reduces experimental hepatic fibrosis, and in vitro studies suggest a potential ...
Lauren G. Poole, Asmita Pant, Holly M. Cline‐Fedewa, Kurt J. Williams, Bryan L. Copple, Joseph S. Palumbo, James P. Luyendyk   +6 more
doaj   +1 more source

Toll-like receptor 5 tunes hepatic and pancreatic stellate cells activation

BMJ Open Gastroenterology, 2023
Objective Stellate cells are responsible for liver and pancreas fibrosis and strictly correlate with tumourigenesis. Although their activation is reversible, an exacerbated signalling triggers chronic fibrosis.
Malte Buchholz, Detlef Schuppan, Pietro Di Fazio, Sophia Mielke, Isabell T Böhm, Sami Matrood, Thaddeus Wissniowski   +6 more
doaj   +1 more source