Results 11 to 20 of about 70,274 (304)

Co-targeting HGF/cMET Signaling with MEK Inhibitors in Metastatic Uveal Melanoma. [PDF]

, 2017
Patients with metastatic uveal melanoma usually die within 1 year of diagnosis, emphasizing an urgent need to develop new treatment strategies. The liver is the most common site of metastasis.
Aplin, Andrew E., Cheng, Hanyin, Chua, Vivian, Davies, Michael A., Kageyama, Ken, Liao, Connie, Purwin, Timothy J., Sato, Takami, Terai, Mizue   +8 more
core   +2 more sources

Hepatic stellate cell progenitor cells [PDF]

Journal of Gastroenterology and Hepatology, 2012
AbstractHepatic stellate cells (HSCs) are recognized as a major player in liver fibrogenesis. Upon liver injury, HSCs differentiate into myofibroblasts and participate in progression of fibrosis and cirrhosis. Additional cell types such as resident liver fibroblasts/myofibroblasts or bone marrow cells are also known to generate myofibroblasts.
openaire   +2 more sources

Hepatic Stellate Cells Support Hematopoiesis and are Liver-Resident Mesenchymal Stem Cells

Cellular Physiology and Biochemistry, 2013
Background/Aims: Hematopoiesis can occur in the liver, when the bone marrow fails to provide an adequate environment for hematopoietic stem cells.
Claus Kordes, Iris Sawitza, Silke Götze, Dieter Häussinger   +3 more
doaj   +1 more source

The C-type lectin COLEC10 is predominantly produced by hepatic stellate cells and involved in the pathogenesis of liver fibrosis

Cell Death and Disease, 2023
Hepatic stellate cell is one of the major nonparenchymal cell types in liver. It has been proved the hepatic stellate cells are activated upon liver injury and produce excessive extracellular matrix to induce liver fibrosis.
Mengfan Zhang, Yang Jing, Wenze Xu, Xiaojing Shi, Wenguang Zhang, Pengfei Chen, Xiaocang Cao, Xinwei Han, Xuhua Duan, Jianzhuang Ren   +9 more
doaj   +1 more source

Role of cytoglobin, a novel radical scavenger, in stellate cell activation and hepatic fibrosis [PDF]

Clinical and Molecular Hepatology, 2020
Cytoglobin (Cygb), a stellate cell-specific globin, has recently drawn attention due to its association with liver fibrosis. In the livers of both humans and rodents, Cygb is expressed only in stellate cells and can be utilized as a marker to distinguish
Le Thi Thanh Thuy, Hoang Hai, Norifumi Kawada   +2 more
doaj   +1 more source

Amiloride reduces portal hypertension in rat liver cirrhosis [PDF]

, 2010
Objective This study aimed to investigate the effect of amiloride on portal hypertension. Amiloride is known to inhibit Na(+)/H(+) exchangers on activated hepatic stellate cells.
Beitinger, Frigga, Bystron, Markus, De Toni, Enrico N., Gerbes, Alexander L., Hartmann, Anna C., Hennenberg, Martin, Steib, Christian J.   +6 more
core   +1 more source

Extracellular Vesicles from Steatotic Hepatocytes Provoke Pro-Fibrotic Responses in Cultured Stellate Cells

Biomolecules, 2022
Hepatic steatosis and chronic hepatocyte damage ultimately lead to liver fibrosis. Key pathophysiological steps are the activation and transdifferentiation of hepatic stellate cells.
Maria Teresa Koenen, Elisa Fabiana Brandt, Dawid Marcin Kaczor, Tim Caspers, Alexandra Catharina Anna Heinzmann, Petra Fischer, Daniel Heinrichs, Theresa Hildegard Wirtz, Christian Trautwein, Rory R Koenen, Marie-Luise Berres   +10 more
doaj   +1 more source

Different effects of rat interferon alpha, beta and gamma on rat hepatic stellate cell proliferation and activation

BMC Cell Biology, 2002
Background Liver fibrosis is the common sequel of chronic liver diseases. Recent studies have identified hepatic stellate cells as the primary cell type mediating hepatic fibrogenesis.
Minuk Gerald Y, Zhang Manna, Shen Hong, Gong Yuewen   +3 more
doaj   +1 more source

A Selective PPARγ Modulator Reduces Hepatic Fibrosis

Biology, 2020
Hepatic fibrosis is the accumulation of excess collagen as a result of chronic liver injury. If left unabated, hepatic fibrosis can lead to the disruption of the liver architecture, portal hypertension, and increased risk of progression to cirrhosis and ...
Benita L. McVicker, Frederick G. Hamel, Ronda L. Simpson, Robert G. Bennett   +3 more
doaj   +1 more source

Immunotherapy in hepatocellular carcinoma: the complex interface between inflammation, fibrosis, and the immune response. [PDF]

, 2019
Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide and confers a poor prognosis. Beyond standard systemic therapy with multikinase inhibitors, recent studies demonstrate the potential for robust and durable responses ...
Fong, Lawrence, Keenan, Bridget P, Kelley, Robin K   +2 more
core   +2 more sources