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Targeting Hepatic Stellate Cells for the Prevention and Treatment of Liver Cirrhosis and Hepatocellular Carcinoma: Strategies and Clinical Translation. [PDF]

Pharmaceuticals (Basel)
Xiong H, Guo J.
europepmc   +1 more source

Stiffness-activated hepatic stellate cells boost HCC migration via TGM2/ITGB1-mediated matrix remodeling and mitochondrial transfer. [PDF]

JHEP Rep
Wang M, Xu Y, Meng Y, Xie W, Chen J, Du J.   +5 more
europepmc   +1 more source

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Studying Hepatic Stellate Cell Senescence

2023
Hepatic stellate cells (HSCs) are the key effector cells in liver fibrosis. They are the main producers of excessive amounts of extracellular matrix components during fibrogenesis and therefore a potential target for the treatment of liver fibrosis.
Sandra A, Serna-Salas, Abel A, Soto-Gámez, Zongmei, Wu, Myrthe, Klaver, Han, Moshage   +4 more
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Cryopreservation of hepatic stellate cells

Journal of Hepatology, 2006
Isolated rat hepatic stellate cells (HSC) are taken as a valuable in vitro model to study hepatic fibrogenesis, biotransformation of pharmaceutics, gene expression, transcription factors controlling HSC behaviour, and for the establishment of long-term cultures. Consequently, methods for the isolation and maintenance of HSC cultures are well documented.
Svenja, Neyzen, Eddy, Van de Leur, Erawan, Borkham-Kamphorst, Jens, Herrmann, Günter, Hollweg, Axel M, Gressner, Ralf, Weiskirchen   +6 more
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P311 modulates hepatic stellate cells migration

Liver International, 2014
AbstractBackground & AimsLiver fibrosis is induced by the accumulation of extracellular matrix, deposited mainly by activated hepatic stellate cells (HSCs). One key characteristic of stellate cell activation is the directional migration to the site of injury during the wound‐healing process.
Stradiot, Leslie, Linck Machado Guimaraes, Eduardo, Mannaerts, Inge, Schroyen, Ben, van Grunsven, Leo A   +4 more
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Hepatic stellate cells

1998
The hepatic stellate cell (HSC) has emerged as a major regulator of normal liver homeostasis and growth, as well as a key effector in the hepatic fibrogenic response. In this chapter, we review the biological characteristics of the hepatic stellate cell, addressing historical perspectives, morphologic characteristics, methods of isolation, and their ...
Victor Ankoma-Sey, Scott L. Friedman
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Mechanisms of hepatic stellate cell activation

Nature Reviews Gastroenterology & Hepatology, 2017
Hepatic fibrosis is a dynamic process characterized by the net accumulation of extracellular matrix resulting from chronic liver injury of any aetiology, including viral infection, alcoholic liver disease and NASH. Activation of hepatic stellate cells (HSCs) - transdifferentiation of quiescent, vitamin-A-storing cells into proliferative, fibrogenic ...
Takuma, Tsuchida, Scott L, Friedman
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Transcriptional Regulation in Hepatic Stellate Cells

Seminars in Liver Disease, 2001
Modulation of gene expression through altered transcription regulates stellate cell behavior in normal liver and following hepatic injury. Transcription factors are generally classified according to conserved motifs within either the activation- or DNA- binding domains of the molecules.
F J, Eng, S L, Friedman
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Dilinoleoylphosphatidylcholine decreases hepatic stellate cell activation

Journal of Laboratory and Clinical Medicine, 1999
The prevention of cirrhosis in alcohol-fed baboons by the administration of a soybean extract-43% to 50% of which was dilinoleoyl-phosphatidylcholine (DLPC) and 24% of which was 1,palmitoyl 2,linoleoyl-phosphatidylcholine (PLPC)-was associated with a significant reduction in the number of stellate cells transformed to myofibroblast-like cells. To study
J, Poniachik, E, Baraona, J, Zhao, C S, Lieber   +3 more
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