Results 151 to 160 of about 162,168 (205)

Animal models for autoimmune hepatitis

Autoimmunity Reviews, 2007
The liver is the target of adverse immune reactions in three putative autoimmune diseases: autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC). These three diseases can be distinguished by clinical, histological, and immunological features.
Urs, Christen, Martin, Holdener, Edith, Hintermann   +2 more
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Animal Models for Hepatitis E Virus

2023
Animal models are one of the most important tools in the study of human hepatitis E virus (HEV) infection. They are particularly important in light of the major limitations of the cell culture system for HEV. Besides nonhuman primates, which are extremely valuable because of their susceptibility to HEV genotypes 1-4, animals like swine, rabbit, and ...
Tianxu, Liu, Lin, Wang, Ling, Wang
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New Animal Models for Autoimmune Hepatitis

Seminars in Liver Disease, 2009
Autoimmune hepatitis (AIH) is often diagnosed late in the disease course and usually requires lifelong immunosuppressive therapy. Unfortunately, the etiology of the disease and the mechanisms leading to the autoimmune destruction of the liver parenchyma are only poorly understood.
Urs, Christen, Edith, Hintermann, Elmar, Jaeckel   +2 more
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Animal Models for Hepatitis C

2013
Hepatitis C remains a global epidemic. Approximately 3 % of the world's population suffers from chronic hepatitis C, which is caused by hepatitis C virus (HCV)-a positive sense, single-stranded RNA virus of the Flaviviridae family. HCV has a high propensity for establishing a chronic infection. If untreated chronic HCV carriers can develop severe liver
Eva, Billerbeck, Ype, de Jong, Marcus, Dorner, Cynthia, de la Fuente, Alexander, Ploss   +4 more
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Animal models of fulminant hepatic failure

Digestive Diseases and Sciences, 1991
The six requirements for a satisfactory animal model of fulminant hepatic failure are reversibility, reproducibility, death from liver failure, a therapeutic window, a large animal model, and minimal hazard to personnel. Different models may be required to evaluate the various types of liver failure seen in man.
J, Terblanche, R, Hickman
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Hepatitis E viruses in humans and animals

Animal Health Research Reviews, 2004
AbstractHepatitis E virus (HEV) is an emerging pathogen belonging to a newly recognized family of RNA viruses (Hepeviridae). HEV is an important enterically transmitted human pathogen with a worldwide distribution. It can cause sporadic cases as well as large epidemics of acute hepatitis. Epidemics are primarily waterborne in areas where water supplies
S Denise, Goens, Michael L, Perdue
openaire   +2 more sources

Animal models of autoimmune hepatitis

Expert Review of Gastroenterology & Hepatology, 2010
Animal models of autoimmune hepatitis have been important in defining pathogenic mechanisms, and they promise to aid in the evaluation of new molecular and cellular treatments. They have evolved from models based on crude liver homogenates that produced a transient hepatitis to models that express antibodies to human antigens, manifest liver ...
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Animal Models of Autoimmune Hepatitis

Seminars in Liver Disease, 2002
Autoimmune hepatitis (AIH) is difficult to study in humans because of the late diagnosis, the heterogenic genetic background and the lack of tissue specimens. Therefore, animal models have been used for more than 90 years to study liver-specific immune regulation.
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Characterization of an animal model of hepatic metastasis

Journal of Gastroenterology and Hepatology, 1996
AbstractThe experimental study of possible therapies for control of the growth of liver metastases requires the availability of a model which is technically feasible and appears to exhibit growth characteristics similar to human tumours. We report on the development of an intrasplenic injection model of liver metastases, and describe the histology ...
D, Kuruppu, C, Christophi, J F, Bertram, P E, O'Brien   +3 more
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Complications of Hepatic Surgery in Companion Animals

Veterinary Clinics of North America: Small Animal Practice, 2011
The most common hepatic procedures performed in companion animals are liver biopsies and partial or complete liver lobectomies. Although these procedures are relatively simple to perform in healthy animals, surgery in clinical patients with liver disease is often complicated by the presence of significant systemic illness or by the technical challenges
Lauren R, May, Stephen J, Mehler
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