Results 161 to 170 of about 162,168 (205)

Animal models for the study of hepatic fibrosis

Best Practice & Research Clinical Gastroenterology, 2011
Animal models are being used for several decades to study fibrogenesis and to evaluate the anti-fibrotic potential of therapies and strategies. Although immensely valuable for our understanding of pathophysiological processes, they remain models and none of them reproduces a human disease.
Peter, Starkel, I A, Leclercq
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The benefit of animal models for autoimmune hepatitis

Best Practice & Research Clinical Gastroenterology, 2011
Autoimmune hepatitis (AIH) is a chronic liver disease which is normally recognized during late stage of the disease. Due to limited knowledge about the onset and course of disease and need for chronic immunosuppression with significant side-effects there is a requirement for a good preclinical animal model, mirroring main characteristics of AIH.
Elmar, Jaeckel, Matthias, Hardtke-Wolenski, Katja, Fischer   +2 more
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Animal Models of Hepatic Failure and Hepatic Encephalopathy

1992
Acute fulminant hepatic failure (FHF) in man is a clinical syndrome that occurs as a result of a sudden and severe impairment of liver function. This may in some cases be associated with massive necrosis of liver cells; in other circumstances, metabolic abnormalities, often accompanied morphologically by microvesicular steatosis, result in a similar ...
B. J. Potter, P. D. Berk
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Animal Models of Porphyria with Hepatic Involvement

Seminars in Liver Disease
The porphyrias are a group of metabolic disorders that are caused by defects in one of the eight enzymes that synthesize heme. A common feature of all porphyrias is accumulation of porphyrin precursors or porphyrins, which are intermediates of the heme biosynthesis pathway.
Oluwashanu, Balogun, Kari, Nejak-Bowen
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Animal Models of Hepatic Encephalopathy and Hyperammonemia

1994
Animal models of chronic liver disease with hyperammonemia are currently available to investigators. Two in particular have been utilized extensively. Carbon tetrachloride induced (CCl4) cirrhosis in the rat and portacaval shunt in the same species and other animals particularly the dog. In regards to hepatic encephalopathy, however, the CCl4 cirrhosis
K D, Mullen, S, Birgisson, R C, Gacad, H, Conjeevaram   +3 more
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Animal experiments on infections hepatitis

Archiv f�r die gesamte Virusforschung, 1948
The experiments of Havens, Ward, Drill and Paul, a Neefe and his associates4, 5,~,~ and:Paul, Havens, Sabin and Philip 9 on human volunteers make the virus etiology of infectious hepatitis at the least highly probable. The virus seems to be present in the blood, the feces and perhaps in the urine and the throat washings. As the human experiment has its
Verlinde, J.D., Boer, H.D.
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Animal Models of Cutaneous and Hepatic Fibrosis

2012
Fibrosis occurs as a part of normal wound healing. However, excessive or dysregulated fibrosis can lead to severe organ dysfunction and is a feature of a variety of diseases. Due to its insidious onset, fibrosis tends to go undetected in its early stages. This is in part why these diseases remain so poorly understood.
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Halothane hepatitis: Attempt to develop an animal model

International Journal of Immunopharmacology, 1987
Patients with liver damage following halothane anaesthesia (halothane hepatitis) have circulating antibodies reacting with plasma membrane determinants present on hepatocytes isolated from rabbits previously exposed to halothane. In an attempt to develop an animal model of halothane hepatitis, rabbits were immunised with hepatocytes isolated from ...
J M, Neuberger, J G, Kenna, R, Williams
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The rabbit as an animal model of hepatic lipase deficiency

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1989
A natural deficiency of hepatic lipase in rabbits has been exploited to gain insights into the physiological role of this enzyme in the metabolism of plasma lipoproteins. A comparison of human and rabbit lipoproteins revealed obvious species differences in both low-density lipoproteins (LDL) and high-density lipoproteins (HDL), with the rabbit ...
M A, Clay, G J, Hopkins, C P, Ehnholm, P J, Barter   +3 more
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Viral hepatitis, type B, in experimental animals

The American Journal of the Medical Sciences, 1975
Evidence of natural infection with hepatitis B virus (HBV) in chimpanzees was followed by demonstration that this species provides a highly sensitive animal model system for experimental type B hepatitis. With rare exceptions, inoculation of sero-negative chimps with materials containing infectious HBV produces serologic evidence of infection including
L F, Barker, J E, Maynard, R H, Purcell, J H, Hoofnagle, K R, Berquist, W T, London   +5 more
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