Results 201 to 210 of about 164,357 (279)

Expression of CD38 on resting peripheral iNKT cells defines an immature subpopulation with distinct functionality in humans

Immunology &Cell Biology, EarlyView.
In this study, we characterize a distinct subpopulation of undifferentiated invariant natural killer T (iNKT) cells in the peripheral blood of healthy adults, which are characterized by CD38 expression in a resting state. This CD38+ subset closely resembles iNKT cells from cord blood and thymus, exhibiting a unique cytokine profile and alterations in ...
Christopher Menne, Naeimeh Tavakolinia, Louis Perriman, Wiebke Moskorz, Christine Cosmovici, Andreas Walker, Lara Olejnik, Katharina Raba, Mei RM Du, Fernando J Rossello, Igor E Konstantinov, Stuart P Berzins, Daniel G Pellicci, Jörg Timm   +13 more
wiley   +1 more source

Drug-induced liver injury in inflammatory bowel disease: Challenges in diagnosis and monitoring. [PDF]

World J Hepatol
Singh A, Bhardwaj A, Kaur H, Bawa A, Midha V, Sood A.   +5 more
europepmc   +1 more source

Innate Immune Activation Is a Strong Suppressor of CCL22 and Impedes Regulatory T Cell–Dendritic Cell Interaction

Immunology, EarlyView.
During homeostasis, CCL22 is secreted by dendritic cells (DC), which mediate contacts between regulatory T cells (Treg) and DC to maintain immune balance. Activation of innate immunity via microbes or pattern recognition receptor (PRR) agonists induces the secretion of several soluble factors (e.g., type I and II interferons, IL‐10), which mediate ...
Ignazio Piseddu, Jan Gärtig, Stephan Eiber, Stefan Moder, Raffael Thaler, Matthias Thaler, Juliane Gruen, Marlies Vornhülz, Kevin Bahner, Luana Messa, Benjamin Kühnemuth, Jennifer Müller, Konstantin Schnell, Antonia Beimert, Carolin Perleberg, Natascha Röhrle, Maximilian Martin Ludwig Knott, Linda Hammann, Vanessa Wittmann, Patrick Layritz, Moritz Rapp, Carole Bourquin, Julia Mayerle, Stefan Endres, David Anz   +24 more
wiley   +1 more source

Systemic PCSK9 elevation characterises autoimmune liver disease across sexes. [PDF]

Sci Rep
Mester P, Pavel V, Stoeckert P, Müller M, Tews HC, Buechler C.   +5 more
europepmc   +1 more source

Epidemiology and Genetics of Rheumatic Diseases Suggest a Constant Rate of DNA Damage as Underlying Cause

Immunology, EarlyView.
A constant rate of DNA damage that is not perfectly repaired will cause a constant rate of DNA mutations. The chance of mutation will increase if DNA is prone to damage, such as occurs in somatic hypermutation (SHM) hotspots and GC‐rich DNA. Thus, if one mutation‐prone DNA site drives disease, the age of onset of disease and degree of penetrance should
Piet C. de Groen
wiley   +1 more source

Hypereosinophilic syndrome with pulmonary and hepatic involvement mimicking autoimmune disease. [PDF]

Oxf Med Case Reports
Chakravarty K, Ravindran S, Panda PK, Deol A, Singh A, Sindhwani G.   +5 more
europepmc   +1 more source

The Role of NLRP1, AIM2 and MEFV Inflammasomes in the High‐Intensity Interval Training of Individuals With Obesity

Immunology, EarlyView.
This study shows that 8 weeks of high‐intensity interval training (HIIT) modulate inflammasome‐related gene expression in individuals with obesity. HIIT increased AIM2, MEFV, CARD16 and CARD18 expression, with CARD16 upregulation supporting reduced inflammation through inhibition of caspase‐1 activation and lower IL‐1β levels.
Ana Luíza Pereira Assunção Silveira, Daniela Alves de Abreu, Amanda de Lima Santos Musto, Luiz Henrique da Silva Nali, Jônatas Bussador do Amaral, André Luis Lacerda Bachi, Marina Tiemi Shio, Paula Rezende‐Teixeira, Carolina Nunes França   +8 more
wiley   +1 more source

Trends in Liver Transplantation for Acute Liver Failure in a Spanish Multicenter Cohort. [PDF]

Transpl Int
Conde Amiel I, Martínez Delgado S, Bosca Robledo A, Senosiáin Labiano M, Martín Mateos RM, Almohalla Álvarez C, González Diéguez ML, Lorente Pérez S, Otero Ferreiro A, Rodríguez-Soler M, Herrero JI, Aceituno L, Fernández Yunquera A, Berenguer M, Aguilera Sancho-Tello V.   +14 more
europepmc   +1 more source

Risk factors for persistent decline in eGFR of Japanese patients with diabetes: Analysis using a large‐scale diabetes registry J‐DREAMS

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Aims/Introduction This study aimed to identify clinical predictors associated with sustained decline in estimated glomerular filtration rate (eGFR) among Japanese individuals diagnosed with diabetes mellitus. Materials and Methods We conducted a retrospective analysis using J‐DREAMS (Japan Diabetes compREhensive database project based on an ...
Kota Yamada, Mitsuru Ohsugi, Yuichiro Ito, Hiroki Uchida, Takumi Lee, Kohjiro Ueki   +5 more
wiley   +1 more source

A Complex Case of Hemophagocytic Lymphohistiocytosis Secondary to Untreated Hepatitis C: Diagnostic Challenges. [PDF]

J Hematol
Alhaj Z, Konopnicki A, Almubaid Z, Roy K, Le T, Park PS.   +5 more
europepmc   +1 more source