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Autoimmune hepatitis and pregnancy
Best Practice & Research Clinical Obstetrics & Gynaecology, 2020Autoimmune hepatitis (AIH) is a rare liver disease of autoimmune aetiology that classically affects women at reproductive age. Diagnosis of AIH is not always straightforward, and other causes of chronic liver disease must be excluded. Pregnancy in patients with AIH is associated with an increased risk of adverse maternal and foetal outcomes.
A, Braga, C, Vasconcelos, J, Braga
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Autoimmune Hepatitis in the Elderly
American Journal of Gastroenterology, 2001Autoimmune hepatitis (AIH) is widely believed to be a disease of young women and menopause. Little is known about the frequency and clinical characteristics in patients aged > or =65 yr.We reviewed charts of 120 consecutive outpatients with known AIH to identify patients who were diagnosed at the age of 65 or older. These 20 patients (median age, 69 yr)
C, Schramm +4 more
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The Indian Journal of Pediatrics, 1995
Autoimmune hepatitis can present as either acute or chronic disease in children. Clinical and laboratory features, including association with extrahepatic autoimmune syndromes and prompt response to immunosuppressive treatment, circulating autoantibodies and hypergammaglobulinemia, suggest an immune etiology.
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Autoimmune hepatitis can present as either acute or chronic disease in children. Clinical and laboratory features, including association with extrahepatic autoimmune syndromes and prompt response to immunosuppressive treatment, circulating autoantibodies and hypergammaglobulinemia, suggest an immune etiology.
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Pathogenesis of autoimmune hepatitis
Clinics in Liver Disease, 2002Autoimmune hepatitis is initiated by CD4 T cells that recognize self-antigen. The effector cells differentiate into functional phenotypes according to cytokines in the microenvironment and the nature of the triggering antigen. Hepatocytes can express class II molecules and present antigenic peptides through a bystander mechanism.
Vergani, D +3 more
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Best Practice & Research Clinical Gastroenterology, 2003
M P, Manns, C P, Strassburg
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M P, Manns, C P, Strassburg
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The Geoepidemiology of Autoimmune Hepatitis
Clinical Reviews in Allergy & ImmunologyAutoimmune hepatitis (AIH) is typically a chronic, inflammatory, and progressive liver disease of autoimmune origin. Currently, two recognized types are identified in clinical practice: type 1 and type 2. The disease can occur in all geographic regions and racial/ethnic groups worldwide, but shows marked variations.
Yang, Li +5 more
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Transplantation for Autoimmune Hepatitis
Seminars in Liver Disease, 2002Autoimmune hepatitis (AIH) is a good indication for liver transplantation, with 5- and 10-year survival rates approaching 75%. Determining the timing for transplantation remains difficult because progression to end-stage disease may be difficult to predict. After transplantation, the patients are at risk of recurrent AIH.
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TNF receptor 2 pathway: drug target for autoimmune diseases
Nature Reviews Drug Discovery, 2010Denise Faustman +2 more
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