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Pathogenesis of autoimmune hepatitis
Clinics in Liver Disease, 2002Autoimmune hepatitis is initiated by CD4 T cells that recognize self-antigen. The effector cells differentiate into functional phenotypes according to cytokines in the microenvironment and the nature of the triggering antigen. Hepatocytes can express class II molecules and present antigenic peptides through a bystander mechanism.
Vergani, D +3 more
openaire +2 more sources
Pathogenesis of autoimmune hepatitis
Best Practice & Research Clinical Gastroenterology, 2011The mechanisms underlying the pathogenesis of autoimmune hepatitis are not fully understood, though there is growing evidence that genetic predisposition, molecular mimicry and/or impairment of regulatory T-cells are involved in the initiation and perpetuation of the autoimmune liver attack.
Liberal, Rodrigo +3 more
openaire +3 more sources
Transplantation for Autoimmune Hepatitis
Seminars in Liver Disease, 2002Autoimmune hepatitis (AIH) is a good indication for liver transplantation, with 5- and 10-year survival rates approaching 75%. Determining the timing for transplantation remains difficult because progression to end-stage disease may be difficult to predict. After transplantation, the patients are at risk of recurrent AIH.
openaire +2 more sources
The Effect of Infections on Susceptibility to Autoimmune and Allergic Diseases
New England Journal of Medicine, 2002Jean-François Bach
exaly
Identification of a Novel Antibody Associated with Autoimmune Pancreatitis
New England Journal of Medicine, 2009Claudio Lunardi +2 more
exaly

