Results 201 to 210 of about 428,885 (246)

Indoleamine 2,3‐Dioxygenase 1 as an Adjunctive Histopathological Marker of Cholangitis Activity in Primary Biliary Cholangitis

Hepatology Research, EarlyView.
IDO‐1 immunostaining identifies primary biliary cholangitis even in morphologically subtle bile duct lesions. IDO‐1 expression reflects cholangitis activity and is suppressed by ursodeoxycholic acid treatment, indicating its value as a dynamic diagnostic adjunct rather than a static marker of chronic damage.
Kaori Yoshimura, Shinji Shimoda, Ryoka Masuda, Tram Nguyen Thi, Rui Yang, Quynh Nguyen Thi, Dong Le Thanh, Yuko Tamano, Yasunori Sato, Taro Yamashita, Kenichi Harada   +10 more
wiley   +1 more source

Clinical Outcomes of Gradual Corticosteroid Tapering for Immune Checkpoint Inhibitor‐Induced Liver Injury

Hepatology Research, EarlyView.
Patients with severe ICI‐induced liver injury are commonly treated with corticosteroids, but the optimal tapering strategy remains uncertain. In this study, a gradual corticosteroid tapering strategy based partly on Japanese clinical practice for autoimmune hepatitis was associated with a low rate of relapse and enabled many patients to safely resume ...
Naoto Soma, Yoshihito Uchida, Kayoko Sugawara, Masamitsu Nakao, Nobuaki Nakayama, Yukinori Imai, Suguru Mizuno, Satoshi Mochida   +7 more
wiley   +1 more source

Validation of the Baveno Endoscopy Avoidance Criteria in Japanese Patients With Chronic Liver Disease: A Real‐World Cohort Study

Hepatology Research, EarlyView.
Many patients with chronic liver disease can safely avoid unnecessary screening endoscopy using the Baveno VII criteria. We developed a simple three‐factor score to identify patients at high risk of serious esophageal varices. Using both approaches together may improve the efficiency and safety of endoscopic screening.
Maiko Asami, Yoshihito Uchida, Shohei Tsuji, Satsuki Ando, Kayoko Sugawara, Masamitsu Nakao, Nobuaki Nakayama, Yukinori Imai, Suguru Mizuno, Satoshi Mochida   +9 more
wiley   +1 more source

Discordance Between Japanese and European Definitions of Acute‐on‐Chronic Liver Failure in Alcohol‐Related Cirrhosis: Insights From a 10‐Year Consecutive Cohort

Hepatology Research, EarlyView.
Substantial discordance was observed between Japanese and EASL‐CLIF definitions of acute‐on‐chronic liver failure in alcohol‐related cirrhosis. Many Japanese‐defined cases were classified as EASL‐CLIF grade 0 yet retained non‐negligible 1‐year mortality, highlighting the complementary roles of hepatic‐based and organ failure–based frameworks.
Hidehiro Kamezaki, Nana Yamada, Terunao Iwanaga, Takafumi Sakuma, Koji Takahashi, Junichi Senoo, Makoto Arai, Tatsuo Kanda, Sadahisa Ogasawara, Jun Kato   +9 more
wiley   +1 more source

Histological manifestations of vitamin A toxicity in the liver

Histopathology, EarlyView.
Analysing clinicopathological data from 1960 to 2025, this study characterizes the spectrum of liver injury associated with chronic vitamin A toxicity. Hepatic stellate cell hypertrophy/hyperplasia and sinusoidal fibrosis emerge as the predominant features, providing a morphological basis for diagnosing vitamin A hepatotoxicity.
Giorgio Cazzaniga, Georg Lietz, Dina G. Tiniakos   +2 more
wiley   +1 more source

Cyclin‐dependent kinase 4/6 (CDK4/6) inhibitor‐induced hepatotoxicity and its resolution: a study of seven cases

Histopathology, EarlyView.
CDK4/6 inhibitor‐induced liver injury represents a clinically significant and histologically distinctive form of drug‐induced hepatotoxicity, most commonly encountered with ribociclib. The predominant pattern is severe acute hepatocellular injury, frequently accompanied by lymphocytic cholangitis, a combination that, in the appropriate clinical context,
Sunayana Misra, Lisa Centeno, Dupinder Singh, Romil Saxena, Rifat Mannan   +4 more
wiley   +1 more source

Early On‐Treatment Change in SALT as a Pragmatic Predictor of Ritlecitinib Response in Moderate‐To‐Severe Alopecia Areata: A Real‐World Cohort Study

International Journal of Dermatology, EarlyView.
Ritlecitinib induced rapid clinical improvement in moderate‐to‐severe alopecia areata in real‐world practice. Early change in SALT at Week 12 strongly discriminated Week‐24 responders, supporting a pragmatic treat‐to‐target checkpoint, alongside improvements in clinician‐reported and patient‐reported outcomes and a favorable safety profile.
Giuseppe Gallo, Isotta Giunipero di Corteranzo, Pietro Quaglino, Simone Ribero, Francois Rosset   +4 more
wiley   +1 more source

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Autoimmune hepatitis

Nature Reviews Disease Primers, 2018
Autoimmune hepatitis (AIH) is a severe liver disease that affects children and adults worldwide. The diagnosis of AIH relies on increased serum transaminase and immunoglobulin G levels, presence of autoantibodies and interface hepatitis on liver histology.
Diego Vergani, Aldo J Montano-Loza
exaly   +7 more sources

Autoimmune hepatitis

The Indian Journal of Pediatrics, 1995
Autoimmune hepatitis can present as either acute or chronic disease in children. Clinical and laboratory features, including association with extrahepatic autoimmune syndromes and prompt response to immunosuppressive treatment, circulating autoantibodies and hypergammaglobulinemia, suggest an immune etiology.
Schiff, Eugene, Aiza, Ignacio
openaire   +3 more sources

Autoimmune Hepatitis

Best Practice & Research Clinical Gastroenterology, 2003
We investigated many cases of autoimmune hepatitis depending on an acute phase or a chronic phase and proposed here the crucial points on diagnostic definition and treatment.
M P, Manns, C P, Strassburg
openaire   +3 more sources