Results 121 to 130 of about 102,448 (310)

Seroprevalence and risk assessment of viral hepatitis E infection in a group of exposed persons from Republic of Moldova

Journal of Infection in Developing Countries, 2019
Introduction: Viral hepatitis E is considered to be an important issue for public health in developing countries. The aim of the present study is to evaluate morbidity and risk factors in occupationally exposed groups such as people working on sausage ...
Octavian Sajin, Constantin Spînu, Iurie Pînzaru, Maria Isac, Igor Spînu, Veaceslav Guțu, Angela Paraschiv, Luminița Suveică   +7 more
doaj   +1 more source

Recent advances in the construction of humanized animal models and applications in translational medicine

Animal Models and Experimental Medicine, EarlyView.
Substantial advances have been achieved in the development of humanized mouse models, which have proven highly valuable in evaluating cancer immunotherapies and elucidating the mechanisms of infectious diseases. There is now a growing shift in research toward larger animal models—such as pigs—that offer greater physiological similarity to humans ...
Yanan Lyu, Yong‐Guang Yang, Zheng Hu
wiley   +1 more source

Strengthening Viral Hepatitis Prevention and Control Through a One Health Approach

One Health & Risk Management
Viral hepatitis remains a major global health challenge. The WHO Global Hepatitis Report 2024 estimates that 254 million people are living with hepatitis B, and 50 million people have hepatitis C worldwide.
Jan DROBENIUC
doaj  

Untapped potential of wastewater for animal and potentially zoonotic virus surveillance: Pilot study to detect non-human animal viruses in urban settings

Environment International
Introduction: Wastewater surveillance has become an essential tool for monitoring viral outbreaks and surveillance of human viruses. While PCR-based methods are most frequently used, more advanced techniques, such as shotgun metagenomics in combination ...
Mustafa Karatas, Mandy Bloemen, Jill Swinnen, Inge Roukaerts, Steven Van Gucht, Marc Van Ranst, Elke Wollants, Jelle Matthijnssens   +7 more
doaj   +1 more source

Establishment of Interspecies Somatic Cell Nuclear Transfer and Transgene‐Free Inducible Pluripotent Stem Cells for Versatile Conservation of the Germplasm Resource of Wild Boar

Animal Research and One Health, EarlyView.
Conserving genetic material and even increasing genetic diversity is critical. To conduct the conservation of wild boar germplasm resources, we have successfully obtained healthy cloned wild boars for the first time using interspecies somatic cell nuclear transfer and established transgene‐free iPSCs that can be used to conduct iterative rounds of gene
Chen Gao, Xinyi Zhou, Shigang Gu, Jianbo Li, Jing Wang, Yurong Zhang, Wenxuan Zhao, Xinhua Wei, Liting Lu, Quanmin Zhao, Yongye Huang, Dawei Yu   +11 more
wiley   +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source

Metagenomic analysis of the ferret fecal viral flora.

PLoS ONE, 2013
Ferrets are widely used as a small animal model for a number of viral infections, including influenza A virus and SARS coronavirus. To further analyze the microbiological status of ferrets, their fecal viral flora was studied using a metagenomics ...
Saskia L Smits, V Stalin Raj, Minoushka D Oduber, Claudia M E Schapendonk, Rogier Bodewes, Lisette Provacia, Koert J Stittelaar, Albert D M E Osterhaus, Bart L Haagmans   +8 more
doaj   +1 more source

Avian Bornaviruses Escape Recognition by the Innate Immune System [PDF]

, 2010
Like other pathogens that readily persist in animal hosts, members of the Bornaviridae family have evolved effective mechanisms to evade the innate immune response.
Kothlow, Sonja, Ackermann, Andreas, Stäheli, Peter, Peter Staeheli, Staeheli, Peter, Kaspers, Bernd, Antje Reuter, Andreas Ackermann, Sonja Kothlow, Rinder, Monika, Monika Rinder, Reuter, Antje, Bernd Kaspers   +12 more
core   +1 more source

Characterization and immunogenicity of nanoparticle vaccines displaying embecovirus spike proteins

Biotechnology Progress, EarlyView.
Virus‐like particle vaccines displaying spike proteins from OC43, HKU1 A, and HKU1 B were evaluated in mice for their ability to elicit antibodies against the spike proteins from OC43, HKU1 A, HKU1 B, and HKU1 C. Abstract Endemic human coronaviruses OC43 and HKU1 cause widespread respiratory infections and can be associated with severe illness in ...
Peter J. Halfmann, Augustine Duffy, Alex Wee, Noah Anderson, Jackson Terrell, Yoshihiro Kawaoka, Ravi S. Kane   +6 more
wiley   +1 more source

Inhibitory mechanism of peptides with a repeating hydrophobic and hydrophilic residue pattern on interleukin-10

Human Vaccines & Immunotherapeutics, 2017
Interleukin 10 (IL-10) is a cytokine that is able to downregulate inflammation. Its overexpression is directly associated with the difficulty in the clearance of chronic viral infections, such as chronic hepatitis B, hepatitis C and HIV infection, and ...
Guoying Ni, Yuejian Wang, Scott Cummins, Shelley Walton, Kate Mounsey, Xiaosong Liu, Ming Q. Wei, Tianfang Wang   +7 more
doaj   +1 more source