Results 11 to 20 of about 94,231 (226)

TIM1 (HAVCR1) Is Not Essential for Cellular Entry of Either Quasi-enveloped or Naked Hepatitis A Virions

mBio, 2017
Receptor molecules play key roles in the cellular entry of picornaviruses, and TIM1 (HAVCR1) is widely accepted to be the receptor for hepatitis A virus (HAV), an unusual, hepatotropic human picornavirus.
Anshuman Das, Asuka Hirai-Yuki, Olga González-López, Bethany Rhein, Sven Moller-Tank, Rachel Brouillette, Lucinda Hensley, Ichiro Misumi, William Lovell, John M. Cullen, Jason K. Whitmire, Wendy Maury, Stanley M. Lemon   +12 more
doaj   +1 more source

Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex

Cells, 2020
The hepatitis B virus (HBV) regulatory HBx protein is required for infection, and its binding to cellular damaged DNA binding protein 1 (DDB1) is critical for this function.
Marissa M. Minor, F. Blaine Hollinger, Adrienne L. McNees, Sung Yun Jung, Antrix Jain, Joseph M. Hyser, Karl-Dimiter Bissig, Betty L. Slagle   +7 more
doaj   +1 more source

Downregulated Copper Homeostasis-Related Gene FOXO1 as a Novel Indicator for the Prognosis and Immune Response of Breast Cancer

Journal of Immunology Research, 2022
Copper (Cu) is one of the essential microelements for all living systems. Studies have illustrated the biological significance of Cu homeostasis in human cancers, including breast cancer (BRCA).
Rong Zeng, Bi Peng, Emin Peng
doaj   +1 more source

Hepatitis C Virus Increases Occludin Expression via the Upregulation of Adipose Differentiation-Related Protein. [PDF]

PLoS ONE, 2016
The hepatitis C virus (HCV) life cycle is closely associated with lipid metabolism. In particular, HCV assembly initiates at the surface of lipid droplets.
Emilie Branche, Stéphanie Conzelmann, Clotilde Parisot, Ludmila Bedert, Pierre L Lévy, Birke Bartosch, Sophie Clément, Francesco Negro   +7 more
doaj   +1 more source

A Comprehensive Analysis of HAVCR1 as a Prognostic and Diagnostic Marker for Pan-Cancer

Frontiers in Genetics, 2022
Hepatitis A virus cellular receptor (HAVCR1) is a type-1 integral membrane glycoprotein that plays a key role in immunity and renal regeneration and is abnormally expressed in various tumor types. Nonetheless, the function of HAVCR1 in pan-cancer remains
Sheng Liu, Wenting Tang, Wenting Tang, Jing Cao, Mei Shang, Hengchang Sun, Jiao Gong, Bo Hu   +7 more
doaj   +1 more source

Hepatitis C virus induced miR200c down modulates FAP-1, a negative regulator of Src signaling and promotes hepatic fibrosis. [PDF]

PLoS ONE, 2013
Hepatitis C virus (HCV) induced liver disease is the leading indication for liver transplantation (LTx). Reinfection and accelerated development of fibrosis is a universal phenomenon following LTx. The molecular events that lead to fibrosis following HCV
Sabarinathan Ramachandran, Haseeb Ilias Basha, Nayan J Sarma, Yiing Lin, Jeffrey S Crippin, William C Chapman, Thalachallour Mohanakumar   +6 more
doaj   +1 more source

Tin oxide nanowires suppress herpes simplex virus-1 entry and cell-to-cell membrane fusion.

PLoS ONE, 2012
The advent of nanotechnology has ushered in the use of modified nanoparticles as potential antiviral agents against diseases such as herpes simplex virus 1 and 2 (HSV-1) (HSV-2), human immunodeficiency virus (HIV), monkeypox virus, and hepatitis B virus.
James Trigilio, Thessicar E Antoine, Ingo Paulowicz, Yogendra K Mishra, Rainer Adelung, Deepak Shukla   +5 more
doaj   +1 more source

Molecular Markers of Tubulointerstitial Fibrosis and Tubular Cell Damage in Patients with Chronic Kidney Disease. [PDF]

PLoS ONE, 2015
In chronic kidney disease (CKD), progressive nephron loss causes glomerular sclerosis, as well as tubulointerstitial fibrosis and progressive tubular injury.
Shunsaku Nakagawa, Kumiko Nishihara, Hitomi Miyata, Haruka Shinke, Eri Tomita, Moto Kajiwara, Takeshi Matsubara, Noriyuki Iehara, Yoshinobu Igarashi, Hiroshi Yamada, Atsushi Fukatsu, Motoko Yanagita, Kazuo Matsubara, Satohiro Masuda   +13 more
doaj   +1 more source

Machine learning-based identification of glycosyltransferase-related mRNAs for improving outcomes and the anti-tumor therapeutic response of gliomas

Frontiers in Pharmacology, 2023
Background: Glycosyltransferase participates in glycosylation modification, and glycosyltransferase alterations are involved in carcinogenesis, progression, and immune evasion, leading to poor outcomes.
Chunyu Zhang, Wei Zhou
doaj   +1 more source

Differential expression of hepatitis A virus cellular receptor 2 in human epithelial ovarian cancer.

, 2021
Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer (1). We performed discovery of genes associated with epithelial ovarian cancer and of the high-grade serous ovarian cancer (HGSC) subtype, using published microarray data (2, 3) to compare global gene expression profiles of normal ovary or fallopian tube with that of primary tumors ...
openaire   +2 more sources