Results 11 to 20 of about 152,141 (270)

P28: Programmed cell death 1 (PDCD1) and hepatitis a virus cellular receptor 2 (HAVCR2) regulate CD4⁺ T cells to induce type 2 helper T cell (Th2) bias at the maternal‐fetal interface [PDF]

American Journal of Reproductive Immunology, 2018
openaire   +2 more sources

Bile Goes Viral

Viruses, 2021
Laboratory cultivation of viruses is critical for determining requirements for viral replication, developing detection methods, identifying drug targets, and developing antivirals.
Victoria R. Tenge, Kosuke Murakami, Wilhelm Salmen, Shih-Ching Lin, Sue E. Crawford, Frederick H. Neill, B. V. Venkataram Prasad, Robert L. Atmar, Mary K. Estes   +8 more
doaj   +1 more source

Inhibition of Viral Membrane Fusion by Peptides and Approaches to Peptide Design

Pathogens, 2021
Fusion of lipid-enveloped viruses with the cellular plasma membrane or the endosome membrane is mediated by viral envelope proteins that undergo large conformational changes following binding to receptors.
Nejat Düzgüneş, Narcis Fernandez-Fuentes, Krystyna Konopka   +2 more
doaj   +1 more source

Does mass management of chronic hepatitis C protect the Egyptian population against fulminant coronavirus disease-2019? “Postulating a hypothesis”

The Egyptian Journal of Bronchology, 2022
Coronavirus disease (COVID-19) is caused by the pathogenic virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Egypt has launched a national treatment program to provide a cure for Egyptian patients infected with hepatitis C virus (HCV ...
Essamedin M. Negm
doaj   +1 more source

Differential expression of HAVCR2 gene in pan-cancer: A potential biomarker for survival and immunotherapy

Frontiers in Genetics, 2022
T-cell immunoglobulin mucin 3 (TIM-3) has emerged as a promising immune checkpoint target in cancer therapy. However, the profile of the hepatitis A virus cellular receptor 2 (HAVCR2) gene, encoding TIM-3 expression, is still obscure, along with its role
Hetong Li, Dinglong Yang, Min Hao, Hongqi Liu, Hongqi Liu   +4 more
doaj   +1 more source

Inhibitory activity of limonoids from Khaya grandifoliola C.DC (Meliaceae) against hepatitis C virus infection in vitro [PDF]

Avicenna Journal of Phytomedicine, 2021
Objective: A fraction from Khaya grandifoliola has recently been shown to inhibit hepatitis C virus (HCV) infection and three limonoids (17-epi-methyl-6-hydroxylangolensate, 7-deacetoxy-7-oxogedunin and 7-deacetoxy-7R-hydroxygedunin) were purified from ...
Kouam Arnaud, Njayou Frédéric Nico, Yuan Fei, Babayemi Oladejo, He Hongtao, Mkounga Pierre, Moundipa Paul   +6 more
doaj   +1 more source

A Novel DNA Vaccine Against SARS-CoV-2 Encoding a Chimeric Protein of Its Receptor-Binding Domain (RBD) Fused to the Amino-Terminal Region of Hepatitis B Virus preS1 With a W4P Mutation

Frontiers in Immunology, 2021
A coronavirus SARS-CoV-2, which has caused the pandemic viral pneumonia disease COVID-19, significantly threatens global public health, highlighting the need to develop effective and safe vaccines against its infection.
Hyein Jeong, Yu-Min Choi, Hyejun Seo, Bum-Joon Kim   +3 more
doaj   +1 more source

TIM-3 levels correlate with enhanced NK cell cytotoxicity and improved clinical outcome in AML patients

OncoImmunology, 2021
Accumulating evidence indicates that immune checkpoint inhibitors (ICIs) can restore CD8+ cytotoxic T lymphocyte (CTL) functions in preclinical models of acute myeloid leukemia (AML).
Jana Rakova, Iva Truxova, Peter Holicek, Cyril Salek, Michal Hensler, Lenka Kasikova, Josef Pasulka, Monika Holubova, Marek Kovar, Daniel Lysak, Justin P. Kline, Zdenek Racil, Lorenzo Galluzzi, Radek Spisek, Jitka Fucikova   +14 more
doaj   +1 more source

Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex

Cells, 2020
The hepatitis B virus (HBV) regulatory HBx protein is required for infection, and its binding to cellular damaged DNA binding protein 1 (DDB1) is critical for this function.
Marissa M. Minor, F. Blaine Hollinger, Adrienne L. McNees, Sung Yun Jung, Antrix Jain, Joseph M. Hyser, Karl-Dimiter Bissig, Betty L. Slagle   +7 more
doaj   +1 more source

Hepatoma cell density promotes claudin-1 and scavenger receptor BI expression and hepatitis C virus internalization. [PDF]

, 2009
Hepatitis C virus (HCV) entry occurs via a pH- and clathrin-dependent endocytic pathway and requires a number of cellular factors, including CD81, the tight-junction proteins claudin 1 (CLDN1) and occludin, and scavenger receptor class B member I (SR-BI).
Balfe, Peter, Grove, Joe, Hu, Ke, McKeating, Jane A, Mee, Christopher J, Schwarz, Anne K   +5 more
core   +2 more sources