Results 21 to 30 of about 94,231 (226)

Conformational Flexibility in the CD81-Binding Site of the Hepatitis C Virus Glycoprotein E2

Frontiers in Immunology, 2018
Numerous antibodies have been described that potently neutralize a broad range of hepatitis C virus (HCV) isolates and the majority of these antibodies target the binding site for the cellular receptor CD81 within the major HCV glycoprotein E2.
Luisa J. Ströh, Kumar Nagarathinam, Thomas Krey   +2 more
doaj   +1 more source

In Silico DISCOVERY OF NOVEL HEPATITIS C VIRUS P7-TRANSACTIVATED PROTEIN1INHIBITOR BY USING STRUCTURE-BASED VIRTUAL SCREENING [PDF]

Journal of Productivity and Development, 2017
Hepatitis C Virus (HCV) infection is a serious cause of chronic liver disease worldwide with more than 170 million infected individuals at a risk of developing significant morbidity and mortality. Till date there is no effective drug for the treatment or
Mohamed Hasan, Amal Mahmoud, El-Sayed El-Absawy, Alaa Hemeida, Yahia Khidr, Mahmoud El Hefnawi   +5 more
doaj   +1 more source

Sex-Dependent Outcome of Hepatitis B and C Viruses Infections: Synergy of Sex Hormones and Immune Responses?

Frontiers in Immunology, 2018
Hepatitis B virus (HBV) and hepatitis C virus (HCV) are hepatotropic viruses that differ in their genomic content, life cycle and molecular prognosis.
Anna Ruggieri, Maria Cristina Gagliardi, Simona Anticoli   +2 more
doaj   +1 more source

High Prolyl 4-Hydroxylase Subunit Alpha 3 Expression as an Independent Prognostic Biomarker and Correlated With Immune Infiltration in Gastric Cancer

Frontiers in Genetics, 2022
Background: Gastric cancer (GC) has a high mortality rate and is particularly prevalent in China. The extracellular matrix protein, prolyl 4-hydroxylase subunit alpha 3 (P4HA3), has been implicated in various cancers.
Xiaoji Niu, Xiaoji Niu, Liman Ren, Shoumei Wang, Dong Gao, Mingyue Ma, Aiyan Hu, Hongjun Qi, Shuhui Zhang   +8 more
doaj   +1 more source

Identification of senescence-related molecular subtypes and key genes for prostate cancer

Asian Journal of Andrology, 2023
We identified distinct senescence-related molecular subtypes and critical genes among prostate cancer (PCa) patients undergoing radical prostatectomy (RP) or radical radiotherapy (RT). We conducted all analyses using R software and its suitable packages.
De-Chao Feng, Wei-Zhen Zhu, Xu Shi, Qiao Xiong, Jia You, Qiang Wei, Lu Yang   +6 more
doaj   +1 more source

A novel germline HAVCR2 (TIM-3) compound heterozygous mutation is related to hemophagocytic lymphohistiocytic syndrome in EBV-positive peripheral T-cell lymphoma (NOS) with down-regulated TIM-3 signaling

Frontiers in Oncology, 2022
Recently, it have been reported that Hepatitis A Virus-Cellular Receptor 2(HAVCR2,encoding T-cell immunoglobulin and Mucin-Containing Protein 3[TIM3]) mutations are associated with severe hemophagocytic syndrome(HLH) in subcutaneous panniculitis-like T ...
Yang Zhang, Zhihua Wang, Guoyu Hu, Jieping Li, Yongheng Chen, Yi Jiang, Haiying Zhong, Xianling Liu, Chunhong Hu, Honglin Peng, Yunxiao Xu, Zhao Cheng, Guangsen Zhang   +12 more
doaj   +1 more source

Tim-1 Deficiency Aggravates High-Fat Diet-Induced Steatohepatitis in Mice

Frontiers in Immunology, 2021
Non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH) is commonly associated with obesity and characterized by excessive lipid accumulation and liver inflammation.
Jasmine George, Yuanyuan Zhang, Jacob Sloan, Joya M. Sims, John D. Imig, Xueying Zhao   +5 more
doaj   +1 more source

Infection with hepatitis C virus depends on TACSTD2, a regulator of claudin-1 and occludin highly downregulated in hepatocellular carcinoma.

PLoS Pathogens, 2018
Entry of hepatitis C virus (HCV) into hepatocytes is a complex process that involves numerous cellular factors, including the scavenger receptor class B type 1 (SR-B1), the tetraspanin CD81, and the tight junction (TJ) proteins claudin-1 (CLDN1) and ...
Vandana Sekhar, Teresa Pollicino, Giacomo Diaz, Ronald E Engle, Farah Alayli, Marta Melis, Juraj Kabat, Ashley Tice, Anna Pomerenke, Nihal Altan-Bonnet, Fausto Zamboni, Paolo Lusso, Suzanne U Emerson, Patrizia Farci   +13 more
doaj   +1 more source

Cytokine/chemokine patterns connect host and viral characteristics with clinics during chronic hepatitis C

European Journal of Medical Research, 2012
Background In chronic hepatitis C virus (HCV) infection, liver tissue pathology and HCV genotype are important determinants of clinical and/or treatment-related outcome.
Katsounas Antonios, Trippler Martin, Kottilil Shyam, Lempicki Richard A, Gerken Guido, Schlaak Joerg F   +5 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source