Results 241 to 250 of about 14,072,748 (310)

Dysregulated BCR repertoire and metabolic state of HBsAg-specific B cells in chronic hepatitis B revealed by integrated single-cell analysis. [PDF]

Hepatol Commun
He M, Shen L, Li Y, Hao M, Wang B, Zhang Y, Wu M, Zhang Z, Fang Z, Yuan Z, Chen J.   +10 more
europepmc   +1 more source

Comparison of Healthcare Utilization Before Diagnosis Between Non‐Advanced and Advanced Lung Cancer Patients: A Study Among 72,851 Cases in Germany

International Journal of Cancer, EarlyView.
ABSTRACT There is no study from Germany on the association between stage of lung cancer (LC) and patient characteristics. We aimed to compare advanced versus non‐advanced LC cases regarding indicators of healthcare utilization. Using claims data covering 20% of the German population, we included LC patients diagnosed between 2013 and 2019.
Josephine Küsel‐Kanbach, Oliver Riedel, Ulrike Haug   +2 more
wiley   +1 more source

What is the impact of metabolic dysfunction-associated steatotic liver disease (MASLD) on outcomes in people living with chronic hepatitis B (CHB)? An umbrella review protocol. [PDF]

Wellcome Open Res
Martyn E, Carter J, Barlow M, Olcott F, Ghosh I, Waddilove E, Arenas-Pinto A, Gilson R, Flanagan S, Venter WF, Manne-Goehler J, Hargreaves S, Tsochatizis E, MacDonald D, Matthews PC.   +14 more
europepmc   +1 more source

Tolerability of Adjuvant Nivolumab in Esophageal or Gastroesophageal Junction Cancer: A Real‐World Study

International Journal of Cancer, EarlyView.
ABSTRACT Adjuvant nivolumab is approved for esophageal or gastroesophageal junction cancer after neoadjuvant chemoradiotherapy and resection. In the CheckMate‐577 trial, Grade 3–5 nivolumab‐related adverse events (AEs) occurred in 5% of patients, with early discontinuation due to toxicity in 9%. However, real‐world data on immunotherapy‐related adverse
Michelle Koops van ’t Jagt, Anniek Strijdhorst, Tamara Jessica Huizer, Esther Albertien Kleibeuker, Sarah Derks, Bianca Mostert, Hanneke van Laarhoven, Jacco Juri de Haan   +7 more
wiley   +1 more source

Longitudinal Patterns of Chronic Hepatitis B Care and Treatment Adherence in Australia: A National Linked Data Cohort Study. [PDF]

J Viral Hepat
MacLachlan JH, Romero N, Rowe SL, Allard N, Cowie BC.   +4 more
europepmc   +1 more source

Diabetes Increases Immunotherapy‐Related Toxicity but Not Efficacy in Metastatic Non‐Small Cell Lung Cancer: A Multicenter Retrospective Study

International Journal of Cancer, EarlyView.
ABSTRACT This multicenter retrospective study evaluated the impact of type 2 diabetes mellitus (DM) on clinical outcomes and immune‐related adverse events (irAEs) in 450 patients with metastatic non‐small cell lung cancer (NSCLC) treated with second‐line nivolumab at 17 centers between 2016 and 2024. Among these patients, 118 (26.2%) had DM.
Emre Çakır, Didem Divriklioğlu, Deniz Can Güven, Gamze Serin Özel, Oğuzhan Yıldız, Gamze Emin, Merve Keskinkılıç, Yeşim Ağyol, Onur Yazdan Balçık, Nagihan Kolkıran, Hale Gülçin Yıldırım Doğan, Pervin Can Şancı, Özge Yalıcı, Teoman Şakalar, Yurdagül Danacı, Yakup Düzköprü, Canan Yıldız, Mesut Yılmaz, İlhan Hacıbekiroğlu, Bülent Erdoğan, Saadettin Kılıçkap, Gamze Gököz Doğu, Melek Karakurt Eryılmaz, Atila Yıldırım, İlhan Öztop, İbrahim Vedat Bayoğlu, Şahnura Uzuntaş, Atike Pınar Erdoğan, Emir Çelik, Devrim Çabuk, Erdoğan Selçuk Şeber, Zehra Sadak Öcal, Hacer Demir   +32 more
wiley   +1 more source

Experimental Models of Autoimmune Hepatitis: Disease Fidelity and Translational Relevance. [PDF]

Liver Int
Buitrago-Molina LE, Hardtke-Wolenski M.
europepmc   +1 more source

Non–AIDS‐Defining Cancer Incidence in People With HIV in Milan, Italy, 2000–2023: Temporal Trends and Comparison With the General Population

International Journal of Cancer, EarlyView.
ABSTRACT People with HIV (PWH) are living longer, but contemporary data on non–AIDS‐defining cancers (NADCs) in Italy remain limited. We assessed incident cancers in a retrospective cohort of PWH in Milan, Italy, between January 2000 and December 2023. Follow‐up was grouped into 2000–2007, 2008–2015, and 2016–2023. Incidence rates (IRs) were calculated
Giacomo Pozza, Maddalena Matone, Letizia Oreni, Giorgia Carrozzo, Beatrice Caloni, Maria Vittoria Cossu, Davide Moschese, Anna Lisa Ridolfo, Cristina Gervasoni, Cinzia Fasola, Nicla La Verde, Davide Dalu, Spinello Antinori, Andrea Gori, Andrea Giacomelli   +14 more
wiley   +1 more source

Core protein mutations are key determinants of hepatitis B virus replication during the hepatitis B e antigen-negative stage. [PDF]

J Gen Virol
Flichman D, García MC, Granchetti HN, Campos R, Elizalde MM.   +4 more
europepmc   +1 more source

Tibolone Use Associated With Elevated Hepatocellular Carcinoma Risk: Findings From a Nationwide Cohort

International Journal of Cancer, EarlyView.
ABSTRACT Tibolone, a synthetic steroid with estrogenic, progestogenic, and androgenic activity, is widely prescribed for menopausal symptoms, but its association with hepatocellular carcinoma (HCC) remains unclear. Using data from 117,271 women aged ≥ 45 years in the Korean National Health Insurance Service–Health Screening Cohort, we evaluated ...
Jimin Lee, Hye Jun Kim, Sun Jae Park, Sangwoo Park, Jina Chung, Jiwon Yu, Ju Hyun Kang, Seogsong Jeong, Hyun‐Young Shin, Sang Min Park   +9 more
wiley   +1 more source