Results 101 to 110 of about 281,611 (124)

Circulating tumor DNA in management of primary liver malignancy: A review of the literature and future directions

Journal of Surgical Oncology, EarlyView.
Abstract Primary liver malignancies are a serious and challenging global health concern. The most common primary tumors are hepatocellular carcinoma and cholangiocarcinoma. These diseases portend poor prognosis when presenting with progressive, extensive disease.
Noah X. Tocci, Chase J. Wehrle, Keyue Sun, Chunbao Jiao, Hanna Hong, Abby Gross, Erlind Allkushi, Melis Uysal, Maureen Whitsett Linganna, Katheryn Stackhouse, Koji Hashimoto, Andrea Schlegel, R. Matthew Walsh, Charles Miller, David C. H. Kwon, Federico Aucejo   +15 more
wiley   +1 more source

Development and Validation of a Predictive Risk Score for Blood Transfusion in Patients Undergoing Curative‐Intent Surgery for Intrahepatic Cholangiocarcinoma

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background and Objectives Among patients undergoing liver resection for intrahepatic cholangiocarcinoma (ICC), perioperative bleeding requiring blood transfusion is a common complication, yet preoperative identification of patients at risk for transfusion remains challenging. The objective of this study was to develop a preoperative risk score
Giovanni Catalano, Laura Alaimo, Yutaka Endo, Odysseas P. Chatzipanagiotou, Andrea Ruzzenente, Luca Aldrighetti, Matthew Weiss, Todd W. Bauer, Sorin Alexandrescu, George A. Poultsides, Shishir K. Maithel, Hugo P. Marques, Guillaume Martel, Carlo Pulitano, Feng Shen, François Cauchy, Bas G. Koerkamp, Itaru Endo, Minoru Kitago, Timothy M. Pawlik   +19 more
wiley   +1 more source

Real‐world experience of adjuvant immunotherapy for stages III–IV melanoma: A monocentric observational study

JEADV Clinical Practice, EarlyView.
Abstract Background Adjuvant immunotherapy (AIO) improved recurrence‐free survival (RFS) in patients with resected stages III–IV melanoma. Real‐world data, especially in elderly patients, as well as optimal management of patients who relpases, are still limited.
Manon Blaise, Eric Fontas, Barbara Seitz‐Polski, Laura Troin, Alexandra Picard, Perrine Rousset, Elodie Long‐Mira, Micheline Razzouk‐Cadet, Madleen Chassang, Thierry Passeron, Henri Montaudié   +10 more
wiley   +1 more source

EP300 Modulates MCM8 Transcription and Augments the Malignant Phenotype of Hepatitis B Virus–Positive Hepatocellular Carcinoma Cells

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Chronic infection with the hepatitis B virus (HBV) remains one of the primary drivers of the development of hepatocellular carcinoma (HCC), a highly aggressive malignancy with a grim prognosis. This study focused on the role of E1A‐binding protein p300 (EP300) in the malignant phenotype of HBV‐positive HCC cells and its functional mechanism ...
Fang Xue, Tian‐Feng Sun
wiley   +1 more source

Erosive and annular lesions of the gastric mucosa: Not negligible signs of Treponema pallidum infection

Journal of General and Family Medicine, EarlyView.
Giulia Ciccarese, Antonio Facciorusso, Vanessa De Pace, Francesco Drago   +3 more
wiley   +1 more source

Mapping protein–protein interactions by mass spectrometry

Mass Spectrometry Reviews, EarlyView.
Abstract Protein–protein interactions (PPIs) are essential for numerous biological activities, including signal transduction, transcription control, and metabolism. They play a pivotal role in the organization and function of the proteome, and their perturbation is associated with various diseases, such as cancer, neurodegeneration, and infectious ...
Xiaonan Liu, Lawrence Abad, Lopamudra Chatterjee, Ileana M. Cristea, Markku Varjosalo   +4 more
wiley   +1 more source

Mass spectrometry imaging of N‐linked glycans: Fundamentals and recent advances

Mass Spectrometry Reviews, EarlyView.
Abstract With implications in several medical conditions, N‐linked glycosylation is one of the most important posttranslation modifications present in all living organisms. Due to their nontemplate synthesis, glycan structures are extraordinarily complex and require multiple analytical techniques for complete structural elucidation.
Tana V. Palomino, David C. Muddiman
wiley   +1 more source

Antithrombin: Deficiency, Diversity, and the Future of Diagnostics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Our healthcare system provides reactive sick‐care, treating patients after symptoms have appeared by prescription of generic and often suboptimal therapy. This strategy brings along high costs and high pressure which is not sustainable.
Mirjam Kruijt, Christa M. Cobbaert, L. Renee Ruhaak   +2 more
wiley   +1 more source

Immunomodulatory Effects of Omega‐3 Fatty Acids: Mechanistic Insights and Health Implications

Molecular Nutrition &Food Research, EarlyView.
Omega‐3 fatty acids, derived from dietary sources and supplements, serve as bioactive precursors (ALA, EPA, DHA) that integrate into immune cell membranes. These fatty acids enhance cell membrane fluidity, improve immune cell communication, and modulate key transcription factors like NF‐κB.
Mahmut Bodur, Birsen Yilmaz, Duygu Agagunduz, Yeşim Ozogul   +3 more
wiley   +1 more source

The Antiviral Activity of Polyphenols

Molecular Nutrition &Food Research, EarlyView.
Polyphenols demonstrate remarkable antiviral properties by effectively disrupting multiple biochemical processes essential for viral replication. ABSTRACT Polyphenols are secondary metabolites produced by a large variety of plants. These compounds that comprise the class of phenolic acids, stilbenes, lignans, coumarins, flavonoids, and tannins have a ...
Markus Burkard, Alban Piotrowsky, Christian Leischner, Katja Detert, Sascha Venturelli, Luigi Marongiu   +5 more
wiley   +1 more source