Results 1 to 10 of about 54,525 (278)

Evaluation of fully automated chemiluminescent enzyme immunoassays for hepatitis B core-related antigen components, phosphorylated and non-phosphorylated hepatitis B core antigens: clinical significance and dynamics during hepatitis B e antigen seroconversion [PDF]

Journal of Clinical Microbiology
To assess the performance and clinical relevance of three assays—hepatitis B core-related antigen (HBcrAg), hepatitis B core antigen (HBcAg), and phosphorylated HBcAg (pHBcAg)—in quantifying HBcrAg, a critical biomarker of hepatitis B virus (HBV ...
Takanori Suzuki, Chiharu Ohue, Osamu Arai, Yuka Inose, Katsuya Nagaoka, Shintaro Ogawa, Takako Inoue, Kentaro Matsuura, Katsumi Aoyagi, Shintaro Yagi, Yasuhito Tanaka   +10 more
doaj   +2 more sources

MVA-HBVac—A novel vaccine vector that allows pan-genotypic targeting of hepatitis B virus by therapeutic vaccination [PDF]

Molecular Therapy: Nucleic Acids
Therapeutic vaccination holds the promise to cure chronic hepatitis B virus (HBV) infection. We hypothesize that B cell, CD4, and CD8 T cell responses are necessary to overcome HBV-specific immune tolerance in chronic infection because they accompany the
Anna D. Kosinska, Martin Kächele, Helene A. Kerth, Martin Mück-Häusl, Edanur Ates Öz, Merve Gültan, Lea Hansen-Palmus, Julia Sacherl, Chunkyu Ko, Julia Festag, Michael H. Lehmann, Carolin Mogler, Katja Steiger, Percy A. Knolle, Tanja Bauer, Asisa K. Volz, Ulrike Protzer   +16 more
doaj   +2 more sources

Nuclear Expression of Hepatitis B Virus X Protein Is Associated with Recurrence of Early-Stage Hepatocellular Carcinomas: Role of Viral Protein in Tumor Recurrence [PDF]

Journal of Pathology and Translational Medicine, 2016
Background: Hepatitis B virus (HBV) plays well-known roles in tumorigenesis of hepatocellular carcinoma (HCC) in infected patients. However, HBV-associated protein status in tumor tissues and the relevance to tumor behavior has not been reported.
Jing Jin, Hae Yoen Jung, Kyu Ho Lee, Nam-Joon Yi, Kyung-Suk Suh, Ja-June Jang, Kyoung-Bun Lee   +6 more
doaj   +1 more source

The Relationship of Hepatits B Core Antibody Positivity with Demographic and Laboratory Parameters in Hemodialysis Patients

Haseki Tıp Bülteni, 2021
Aim:The presence of hepatitis B core antibody (HBcAb) is an indication of exposure to hepatitis B virus infection. We aimed to investigate the rates of positive HBcAb and its’ association with demographical and laboratory parameters among patients ...
Ilter Bozaci, Selma Tosun
doaj   +1 more source

Baseline quantitative HBcAb strongly predicts undetectable HBV DNA and RNA in chronic hepatitis B patients treated with entecavir for 10 years

Scientific Reports, 2021
The predictive effect of quantitative anti-hepatitis B core on double-negative HBV DNA and RNA remains unstudied. We observed dynamic changes in this measure in chronic hepatitis B patients receiving entecavir for 10 years, evaluating its predictive ...
Xi Zhang, Xiaocui An, Lei Shi, Xueliang Yang, Yunru Chen, Xiaojing Liu, Jianzhou Li, Feng Ye, Shumei Lin   +8 more
doaj   +1 more source

Blocking entry of hepatitis B and D viruses to hepatocytes as a novel immunotherapy for treating chronic infections [PDF]

, 2021
Background. Chronic hepatitis B and D virus (HBV/HDV) infections can cause cancer. Current HBV therapy using nucleoside analogues (NAs) is life-long and reduces but does not eliminate the risk of cancer.
Ahlén, G, Frelin, L, Jagya, N, Johansson, M, Maravelia, P, Meuleman, Philip, Ni, Y, Pasetto, A, Pater, L, Pérez, NC, Sällberg, M, Urban, S, Verch, G, Verhoye, Lieven   +13 more
core   +1 more source

Action Mechanisms and Scientific Rationale of Using Nasal Vaccine (HeberNasvac) for the Treatment of Chronic Hepatitis B

Vaccines, 2022
Nasvac (HeberNasvac®) is a novel therapeutic vaccine for chronic hepatitis B (CHB). This product is a formulation of the core (HBcAg) and surface (HBsAg) antigens of the hepatitis B virus (HBV), administered by nasal and subcutaneous routes, in a ...
Julio Cesar Aguilar, Jorge Agustin Aguiar, Sheikh Mohammad Fazle Akbar   +2 more
doaj   +1 more source

Dried blood spot is the feasible matrix for detection of some but not all hepatitis B virus markers of infection

BMC Research Notes, 2022
Objective Use of dried blood spots (DBS) for detection of hepatitis B virus (HBV) markers of infection has the potential to facilitate diagnosis of HBV infection especially in resource-limited countries.
Minami Kikuchi, Patrick Lindstrom, Alexandra Tejada-Strop, Tonya Mixson-Hayden, Saleem Kamili, Motoji Sawabe   +5 more
doaj   +1 more source

VelcroVax: a “Bolt-On” Vaccine Platform for Glycoprotein Display

mSphere, 2023
Having varied approaches to the design and manufacture of vaccines is critical in being able to respond to worldwide needs and newly emerging pathogens.
Natalie J. Kingston, Keith Grehan, Joseph S. Snowden, Mark Hassall, Jehad Alzahrani, Guido C. Paesen, Lee Sherry, Connor Hayward, Amy Roe, Sam Stephen, Darren Tomlinson, Antra Zeltina, Katie J. Doores, Neil A. Ranson, Martin Stacey, Mark Page, Nicola J. Rose, Thomas A. Bowden, David J. Rowlands, Nicola J. Stonehouse   +19 more
doaj   +1 more source

Expression of Hepatocyte Hepatitis B Core Antigen and Hepatitis B Surface Antigen as a Marker in the Management of Chronic Hepatitis B Patients

Gut and Liver, 2017
Background/AimsWe aimed to clarify the association of hepatitis B surface antigen (HBsAg)/hepatitis B core antigen (HBcAg) with the disease status and treatment response in patients with chronic hepatitis B (CHB).Methods : We investigated 171 biopsy ...
Sun Young Yim, Tae Hyung Kim, Suh Sang Jun, Eun Sun Kim, Bora Keum, Yeon Seok Seo, Hyung Joon Yim, Yoon Tae Jeen, Hoon Jai Chun, Hong Sik Lee, Soon Ho Um, Chang Duck Kim, Nam Hee Won, Ho Sang Ryu   +13 more
doaj   +1 more source