Results 61 to 70 of about 16,590,594 (260)

Metabolic Signatures for Liver Cancer Diagnosis and Mechanistic Insights: A Large‐Scale, Multicenter Study

Advanced Science, EarlyView.
A large‐scale multicenter serum metabolomics study (13 centers, n = 2,149) identified a 9‐metabolite + AFP diagnostic signature for liver cancer (AUC = 0.93). Among the signature, nicotinamide (NAM) was validated as an oncometabolite: NAM enhances NAD+ synthesis, activating SIRT1 to deacetylate and stabilize HIF1α, thereby driving glycolysis, MAPK ...
Yongjie Xu, Jiachen Wang, Chunmeng Ding, Changfa Xia, Yunyong Liu, Yuanjie Zheng, Sheng Chang, Shaokai Zhang, Yutong He, Ruifang Sun, Yunfeng Xi, Yan Liu, Kun Qian, Wanqing Chen   +13 more
wiley   +1 more source

An antigen-driven B-cell response within the salivary glands of patients with Sjögren’s syndrome [PDF]

, 2002
Infection with a bacterium or virus induces the production of antibodies, specialised protein molecules that bind to and eliminate the microorganism.
Berek, C., Stott, D.I.
core   +4 more sources

Hepatitis B Core-Related Antigen is a Biomarker for off-Treatment Relapse After Long-Term Nucleos(t)ide Analog Therapy in Patients with Chronic Hepatitis B

International Journal of General Medicine, 2021
Guichan Liao,1,2 Xia Ding,1,2 Muye Xia,1,2 Yin Wu,1– 3 Hongjie Chen,1,2 Rong Fan,1,2 Xiaoyong Zhang,1,2 Shaohang Cai,1,2 Jie Peng1,2 1Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China;
Liao G, Ding X, Xia M, Wu Y, Chen H, Fan R, Zhang X, Cai S, Peng J   +8 more
doaj  

Hepatitis B virus vaccination of silvery gibbons (Hylobates moloch) at the Perth Zoo [PDF]

, 2003
Hepatitis B virus (HEV) has been identified in a number of nonhuman primate species, including the Silvery gibbon (Hylobates moloch). The Perth Zoo has a successful Silvery gibbon breeding program and has developed an HBV vaccination regime to protect ...
Fenwick, S., Monaghan, C.L., Warren, K.S., Robertson, I., Payne, K.L., Smith, D.   +5 more
core  

An Adenoviral‐Vectored Tp0326 Vaccine Elicits Robust Functional Antibodies to Prevent Treponema pallidum Dissemination in a Rabbit Model

Advanced Science, EarlyView.
Vaccination promotes cellular infiltration into primary lesions and effectively inhibits T. pallidum dissemination to distal organs. Notably, transfer of lesion tissue from immunized animals fails to establish infection in naive recipients, confirming specific protective immunity.
Yinbo Jiang, Xinyuan Li, Lixia Huang, Xiangcai Zhang, Wujian Ke   +4 more
wiley   +1 more source

Current Status on the Epidemiology of Hepatitis B Virus Infection in İstanbul

Mediterranean Journal of Infection, Microbes and Antimicrobials
Introduction: Despite the availability of safe and effective vaccines against Hepatitis B virus (HBV), the infection remains a significant global health issue.
Mehmet Karabey, Nuran Karabulut, Sema Alaçam   +2 more
doaj   +1 more source

Nuciferine Suppresses Inflammatory Hepatocarcinogenesis by Targeting cPLA2‐Dependent Arachidonic Acid Metabolism

Advanced Science, EarlyView.
Nuciferine directly binds the C2 domain of cPLA2, impairing its Ca2+‐dependent membrane translocation and activation. By suppressing arachidonic acid release and downstream pro‐inflammatory eicosanoid production, nuciferine attenuates NF‐κB signaling and inflammatory hepatocarcinogenesis, revealing cPLA2 as a direct molecular target underlying its ...
Jing Sun, Xinyan Wu, Shuwei Luo, Yilang Liu, Jie Liu, Jun Lu, Weimin Wang, Xiao Feng, Tuo Zhang, Dipak Panigrahy, Jianjun Deng, Xiaojun Liao, Haixia Yang   +12 more
wiley   +1 more source

Middle-aged Subjects With Habitual Low-speed Cycling Exercise Have Greater Mononuclear Cell Responsiveness Against Human Hepatitis B Virus Surface Antigen

International Journal of Gerontology, 2010
Background: Whether middle-aged people with habitual cycling exercise (HCE) at low intensity in the morning have higher immunity against hepatitis B virus than sedentary controls (SCs) is a health issue in the elderly.
Kuen-Chang Hsieh, Yu-Yawn Chen, Tsong-Rong Jang, Yu-Jen Chen   +3 more
doaj   +1 more source

Seroepidemiology of hepatitis B virus in Addis Ababa Ethiopia: transmission patterns and vaccine control [PDF]

, 2003
A community-based seroepidemiological survey of Addis Ababa, Ethiopia was conducted in 1994 to inform on the transmission dynamics and control of hepatitis B virus (HBV) infection.
Cutts, FT, Dejene, A, Cutts, Felicity, Nokes, D. James, Dejene, A., Messele, T., Enquselassie, F., Abebe, A, Nokes, DJ, Messele, T, Abebe, A., Enquselassie, F   +11 more
core   +1 more source

A Biomimetic cRGDyk‐Engineered Platelet Nanoplatform for ACAD11 Delivery to Trigger Pyroptosis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
A biomimetic platelet nanoplatform (OE‐ACAD11@R‐PLT) is developed for targeted hepatocellular carcinoma immunotherapy. By selectively delivering therapeutic plasmids, this system induces mitochondrial dysfunction and triggers robust NLRP3/Caspase‐1/GSDMD‐mediated pyroptosis in tumor cells.
Hongyi Bao, Wei Feng, Wei Zong, Yi Li, Xinyue Qin, Xinyue Wang, Yubo Yang, Guanhua Chen, Yiting Hou, Xuan Tan, Lin Chen, Ming Zhang, Feng Wang   +12 more
wiley   +1 more source