Results 141 to 150 of about 58,962 (264)

Toll Like Receptor 4: A Potential Link Between Obesity and Metabolic Diseases

Obesity Reviews, EarlyView.
ABSTRACT Epidemiological evidence shows that obesity increases the risk of developing metabolic diseases. Nevertheless, the mechanisms behind this connection remain underappreciated. The substantial impact of these disorders on global health has led to extensive research efforts aimed at identifying the pathophysiological links between them.
Ghadeer Alhamar, Joanna Razafiarison, Fawaz Alzaid, Fahd Al‐Mulla, Rasheed Ahmad   +4 more
wiley   +1 more source

CD72 downregulation is associated with increased CD5+ B cell proliferation and IL-10 production via ERK/Syk signaling in chronic HBV infection-associated liver disease. [PDF]

Virus Res
Li B, Zhao L, Zhu Q, Xie S.
europepmc   +1 more source

Beyond Starch: Towards a Scalable Potato Platform for Molecular Farming

Plant Biotechnology Journal, EarlyView.
Re‐engineering potato as a biosafe and host‐optimised platform for plant molecular farming by integrating intrinsic biological traits with targeted engineering strategies. ABSTRACT Thirty‐five years after the first recombinant protein was produced in potato and 30 years after clinical trials of edible vaccines from its tubers, the crop is being ...
Izabela Anna Chincinska, Dorota Sołtys‐Kalina, Audrey Y.‐H. Teh   +2 more
wiley   +1 more source

Bivalent virus-like particles expressing SPECT1 and CSP trigger pre-erythrocytic malaria immunity and protect against transgenic <i>Plasmodium falciparum</i> sporozoite challenge in mice. [PDF]

Front Immunol
Turan G, Mukhopadhyay E, Truby A, Fedorova K, Peralta Alvarez MP, Alharbi NK, Hill AVS, Salman AM.   +7 more
europepmc   +1 more source

Subtypes of Hepatitis B Surface Antigen in Turkey

Japanese Journal of Infectious Diseases, 2005
Yalcinkaya, Kezban Tulay, Ucar, Hasan, Uzun, Mustafa, Esen, Berrin, Shirachi, Ryoichi, Miyamura, Kikuko, Yamamoto, Hiroshi   +6 more
openaire   +2 more sources

Antibiotic‐mediated immune modulation in periodontitis

Periodontology 2000, EarlyView.
Abstract Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth. Although initiated by dysbiotic microbial communities, its progression is largely driven by the host's uncontrolled inflammatory response. While antibiotics have conventionally been employed in periodontitis therapy for their antimicrobial ...
Lina J. Suárez, R. M. Arce, Camila Pinheiro Furquim, Cristiane Gonçalves, Alpdogan Kantarci, Magda Feres, Nidia C. Castro dos Santos   +6 more
wiley   +1 more source

Invalid Nucleic Acid Test Results May Limit Deceased Donor Organ Utilization

Transplant Infectious Disease, EarlyView.
Rare instances occur in which discriminatory NAT results cannot be resolved in deceased organ donor cases. When these events occur the impact on organ donation can be substantial. ABSTRACT Background Nucleic acid testing (NAT) is essential for detecting transmissible viral infections in deceased organ donors and guiding safe organ allocation.
Sara Dionne, Hillary Akana, Kaitlin Logue, Brenden O'Neale, Chris Curran, Sean VanSlyck   +5 more
wiley   +1 more source

Dysfunction of circulating follicular helper T cells in people living with HIV who are HBV small surface protein antibody (HBsAb)-negative despite HBV vaccination. [PDF]

BMC Infect Dis
Sedohara A, Kanno Y, Arai K, Arizono K, Koga M, Nakahara F, Saito M, Adachi E, Yotsuyanagi H.   +8 more
europepmc   +1 more source

Hepatitis B Surface Antigen Loss and Improved Clinical Outcomes in US Individuals With Chronic Hepatitis B Virus Infection. [PDF]

J Viral Hepat
Drysdale M, Chang R, Wang S, Coutinho A, Gielen V, Man T, Song R, Duh MS, Khalili M, Theodore D.   +9 more
europepmc   +1 more source

Impaired hematopoiesis affects apheresis and CAR T‐cell product composition and treatment response

Transfusion, EarlyView.
Abstract Background Chimeric antigen receptor (CAR) T‐cell therapy has transformed the treatment of hematologic malignancies, but its success depends on obtaining sufficient CD3+ T‐cell yields during leukapheresis. This can be difficult in heavily pretreated patients, who often show leukopenia and reduced T‐cell fitness.
Hanna Kuhn, Felix Korell, Angela Hückelhoven‐Krauss, Brigitte Neuber, Miriam Stenzinger, Anita Ludwig‐Husemann, Maria‐Luisa Schubert, Patrick Derigs, Kiavasch Farid, Tim Sauer, Sandra Sauer, Carsten Müller‐Tidow, Peter Dreger, Michael Schmitt, Anita Schmitt   +14 more
wiley   +1 more source