Results 261 to 270 of about 20,528,118 (294)

Citrus depressa peel extract and its polymethoxyflavones mitigate acetaminophen‐induced chronic liver injury in mice through antioxidant activation, epigenetic regulation, and gut microbiota modulation

Journal of the Science of Food and Agriculture, Volume 106, Issue 13, Page 7629-7642, October 2026.
Abstract BACKGROUND Preventing chronic liver damage is essential for maintaining overall health and reducing the risk of serious liver diseases. Acetaminophen (APAP) overdose can lead to severe liver damage due to oxidative stress, and citrus fruits are rich in bioactive compounds that may have health benefits.
Po‐Yao Tsai, Zi‐Han Lin, Guor‐Jien Wei, Liang‐Yi Wu, Tien‐Yuan Wu, Yen‐Chen Tung, Ssu‐Han Huang, Zheng‐Yuan Su   +7 more
wiley   +1 more source

Abstracts of 14th International Symposium on Hodgkin Lymphoma

HemaSphere, Volume 10, Issue S2, October 2026.
wiley   +1 more source

Expression of X Protein and Hepatitis B Virus Replication in Chronic Hepatitis

Expression of X Protein and Hepatitis B Virus Replication in Chronic Hepatitis
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Hepatitis B virus x protein in the pathogenesis of hepatitis B virus-induced hepatocellular carcinoma

Journal of Gastroenterology and Hepatology (Australia), 2011
AbstractCurrently available evidence supports a role for the hepatitis B virus (HBV) x gene and protein in the pathogenesis of HBV‐induced hepatocellular carcinoma (HCC). HBx gene is often included, and remains functionally active, in the HBV DNA that is frequently integrated into cellular DNA during hepatocellular carcinogenesis.
Michael Charles Kew
exaly   +3 more sources

The hepatitis B virus X protein is a potent AMP kinase

Journal of General Virology, 1996
The hepatitis B virus X-protein (HBx) has been expressed in Escherichia coli both as an unfused protein and with an N-terminal hexaHis-containing fusion sequence. Both forms of HBx, after purification, displayed a potent AMP kinase activity, in which HBx phosphorylates AMP to ADP, using ATP as the exclusive phosphate donor.
T A, Dopheide, A A, Azad
openaire   +2 more sources

Expression and purification of the hepatitis B virus X protein

2021
The hepatitis B virus (HBV) genome is made of a small partially double-stranded, circular DNA that encodes four open-reading frames. One important protein encoded by the smallest open reading frame of the viral genome is HBV protein X; this protein has been shown to be essential for HBV replication.
Guila Fakhoury, Patrick J. Loll
openaire   +1 more source

Mapping of B-cell epitopes of the human hepatitis B virus X protein

Journal of Virology, 1990
The immune response to the X protein of human hepatitis B virus (HBV) was studied by epitope mapping by using a set of MS2-HBx fusion proteins and synthetic peptides. Antibodies in sera of patients with acute and chronic HBV infection showed a multispecific immune response.
M. Stemler, T. Weimer, Z. X. Tu, D. F. Wan, LEVRERO, Massimo, C. Jung, G. R. Pape, H. Will   +7 more
openaire   +3 more sources

Hepatitis B virus X protein: a multifunctional viral regulator

Journal of Gastroenterology, 2001
Hepatitis B Virus (HBV) infection is one of the major causes of hepatocellular carcinoma (HCC). X protein (HBx) has been suspected to be oncogenic, although the precise role(s) remain uncertain. HBx is a multifunctional viral regulator that modulates transcription, cell responses to genotoxic stress, protein degradation, and signaling pathways.
openaire   +2 more sources

A functional hepatitis B virus X protein produced in insect cells

Virology, 1991
We have constructed a recombinant baculovirus from Autographa californica nuclear polyhedrosis virus, called AcX, that expresses the gene encoding the hepatitis B virus X protein in infected Spodoptera frugiperda (Sf21AE) insect cells. A 16.5-kDa monomer and a 33-kDa dimer of the X protein were detected in extracts from AcX-infected cells on ...
D F, Spandau, H G, Wang, M J, Fraser, C H, Lee   +3 more
openaire   +2 more sources

[Effects of hepatitis B virus X protein on chronic hepatitis B pathophysiology].

Medicina clinica, 2014
The infection by hepatitis B virus often promotes chronic liver inflammation which progresses to cirrhosis and hepatocellular carcinoma in a high percentage of patients. The persistent activation of the immune system causes an incessant liver damage, which fosters a disorganized stimulation of tissue repair and remodelling phenomena. In turn, the viral
Samuel, Martín-Vílchez, Ricardo, Moreno-Otero, Paloma, Sanz-Cameno   +2 more
openaire   +1 more source