Results 111 to 120 of about 958,101 (344)

RELA Ablation Contributes to Progression of Hepatocellular Carcinoma with TP53R249S Mutation and is a Potential Therapeutic Target

Advanced Science, EarlyView.
Genome‐wide CRISPR/Cas9 based screening identified RELA as a key tumor suppressor in TP53R249S‐mutant HCC. Its loss promotes tumorigenesis and metastasis via DVL1‐mediated Wnt/β‐catenin activation, while its agonist betulinic acid suppresses tumor progression.
Zhiping Wu, Zhe Wang, Diwei Zheng, Yongfang Zheng, Zhiwu Jiang, Jiang Lv, Yueqin Zhu, Heng Jia, Ziyuan Duan, Tingjie Yuan, Qiting Wu, Youguo Long, Shouheng Lin, Yao Yao, Georgia Carson, Jean P. Thiery, Kwan Man, Peng Li   +17 more
wiley   +1 more source

HCV and HBV prevalence based on home blood self-sampling and screening history in the general population in 2016: contribution to the new French screening strategy

BMC Infectious Diseases, 2019
Background The advent of effective direct-acting antivirals (DAAs), has prompted an assessment of the French Hepatitis C virus (HCV) screening strategy, which historically targeted high-risk groups. One of the options put forward is the implementation of
Cécile Brouard, Leïla Saboni, Arnaud Gautier, Stéphane Chevaliez, Delphine Rahib, Jean-Baptiste Richard, Francis Barin, Christine Larsen, Cécile Sommen, Josiane Pillonel, Elisabeth Delarocque-Astagneau, Nathalie Lydié, Florence Lot, the 2016 Health Barometer Group   +13 more
doaj   +1 more source

Glial Fibrillary Acidic Protein (GFAP) as a Mesenchymal marker of Early Hepatic Stellate Cells Activation in Liver Fibrosis in Chronic Hepatitis C Infection. [PDF]

, 1969
Sobia Hassan, Serajuddaula Syed, Shahnaz Imdad Kehar   +2 more
openalex   +1 more source

The Iowa Viral Hepatitis Strategic Plan 2012-2016, August 26, 2014 [PDF]

, 2014
Since the creation of the first viral hepatitis plan in 2004 several documents and advancements have been released that help Iowa plan and prioritize this revision of our hepatitis plan.

core  

NSP7 Molecular Degrader Attenuates Coronaviral Infection Through the β‐TrCP1/FBXO5 Axis

Advanced Science, EarlyView.
Host E3 ligase FBXO5 as a key regulator that promotes K48‐linked ubiquitination and proteasomal degradation of SARS‐CoV‐2 NSP7, thereby suppressing viral replication. NSP7 ubiquitination is co‐regulated by β‐TrCP1 and TAF1. Small molecule BC24877 disrupts β‐TrCP1‐mediated degradation of FBXO5, stabilizing FBXO5 and enhancing NSP7 clearance ...
Yao Tong, Travis B. Lear, Ferhan Tuncer, John J. Villandre, Áine N. Boudreau, Bo Lin, Irene Alfaras, Jason R. Kennerdell, Daniel P. Camarco, Mads B. Larsen, Yun Hua, Yanwen Chen, Meigin E. Chandler, Ricardo Pineda, Simon M. Barratt‐Boyes, John W. Evankovich, Toren Finkel, Yuan Liu, Bill B. Chen   +18 more
wiley   +1 more source

T cell receptor usage and epitope specificity amongst CD8+ and CD4+ SARS-CoV-2-specific T cells

Frontiers in Immunology
IntroductionThe coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has highlighted the critical importance of understanding protective long-lasting immune responses.
Ulrik Fahnøe, Ulrik Fahnøe, Ulrik Fahnøe, Shan Feng, Shan Feng, Shan Feng, Alexander P. Underwood, Alexander P. Underwood, Alexander P. Underwood, Kivin Jacobsen, Amir Ameri, Thomas H. Blicher, Christina S. Sølund, Christina S. Sølund, Christina S. Sølund, Brad R. Rosenberg, Liselotte Brix, Nina Weis, Nina Weis, Jens Bukh, Jens Bukh, Jens Bukh   +21 more
doaj   +1 more source

Virologic Tools for HCV Drug Resistance Testing

Viruses, 2015
Recent advances in molecular biology have led to the development of new antiviral drugs that target specific steps of the Hepatitis C Virus (HCV) lifecycle. These drugs, collectively termed direct-acting antivirals (DAAs), include non-structural (NS) HCV
Slim Fourati, Jean-Michel Pawlotsky
doaj   +1 more source

Fulminant hepatic failure (FHF) due to acute hepatitis C [PDF]

, 1969
Bilal Bin Younis, Rozina Arshad, Saima Khurshid, Junaid Masood, Farhan Nazir, Maham Tahira   +5 more
openalex   +1 more source

Dysfunctional Decidual CD4+T Cells Induce Recurrent Pregnancy Loss via Palmitoylation‐Dependent Tim‐3 Lysosomal Sorting and Degradation

Advanced Science, EarlyView.
Dysfunctional decidual CD4+T cells induce recurrent pregnancy loss via palmitoylation‐dependent Tim‐3 lysosomal sorting and degradation. The integrated bioinformatics, proteomic, functional and model studies elucidate that Tim‐3 is palmitoylated by ZDHHC3 at Cys9. Sortilin bound to and directed palmitoylated Tim‐3 toward lysosome degradation, resulting
Liyuan Cui, Xinhang Meng, Yujie Luo, Jinfeng Qian, Fengrun Sun, Mingke Qiu, Songcun Wang   +6 more
wiley   +1 more source

Hepatitis-C Virus Infection among Injecting Drug Users in Lahore, Pakistan: A Descriptive and Analytical Cross Sectional Study [PDF]

, 1969
Abdul Majeed Akhtar, Sadia Majeed, Muhammad Jamil, Abdul Rehman, Sufia Majeed   +4 more
openalex   +1 more source