Results 71 to 80 of about 1,000,209 (254)

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Conquering C – Going Beyond Cure [PDF]

European Medical Journal Hepatology, 2015
Prof Zeuzem opened the symposium by acknowledging that there is a new era in hepatitis C virus (HCV) treatment, due to the availability of efficacious treatments that could eradicate the disease.
Stefan Zeuzem, Nezam H. Afdhal, Marc Bourlière, Graham Foster, Charles Gore, Jean-Michel Pawlotsky   +5 more
doaj  

Hepatitis Delta Virus Diagnosis [PDF]

Seminars in Liver Disease, 2012
The first step in the diagnosis of hepatitis delta virus (HDV) infection is testing HBsAg-positive individuals for the antibody to the HD antigen (anti-HD).In anti-HD-positive patients, the next step is testing for HDV RNA in serum to determine whether the antibody reflects an ongoing active HDV infection (HDV-RNA-positive) or represents a serologic ...
OLIVERO, Antonella, SMEDILE, Antonina
openaire   +2 more sources

Association of HAMP Expression and CD8+ T‐Cell Infiltration With Atezolizumab–Bevacizumab Response in Hepatocellular Carcinoma

Annals of Gastroenterological Surgery, EarlyView.
In hepatocellular carcinoma treated with atezolizumab–bevacizumab, responders showed RNA‐seq enrichment of immune and chemokine pathways with higher HAMP expression. In resected specimens, immunohistochemistry confirmed increased intratumoral CD8+ T‐cell density and hepcidin (HAMP), supporting HAMP plus CD8 as components of a composite predictor of ...
Shun Nakamura, Yuki Murakami, Yusuke Oshima, Takashi Masuda, Wataru Miyoshino, Hiroomi Takayama, Yoko Kawano, Teijiro Hirashita, Yuichi Endo, Masafumi Inomata   +9 more
wiley   +1 more source

Chronic hepatitis delta virus infection leads to functional impairment and severe loss of MAIT cells.

Journal of Hepatology, 2019
BACKGROUND & AIMS Hepatitis delta virus (HDV) infection is the most severe form of viral hepatitis. Although HDV-associated liver disease is considered immune-mediated, adaptive immune responses against HDV are weak.
Joana Dias, J. Hengst, Tiphaine Parrot, E. Leeansyah, S. Lunemann, David F. G. Malone, S. Hardtke, Otto Strauss, C. Zimmer, L. Berglin, T. Schirdewahn, S. Ciesek, N. Marquardt, T. von Hahn, M. Manns, M. Cornberg, H. Ljunggren, H. Wedemeyer, J. Sandberg, N. Björkström   +19 more
semanticscholar   +1 more source

Long‐term impact of Elexacaftor/Tezacaftor/ivacaftor on pulmonary, nutritional and metabolic outcomes in homozygous F508del cystic fibrosis patients: A real‐world cohort study

British Journal of Clinical Pharmacology, EarlyView.
Aim Elexacaftor/tezacaftor/ivacaftor (ETI) has markedly improved cystic fibrosis (CF) outcomes. However, its long‐term impact on nutrition, metabolism and liver health remains underexplored. We assessed 30‐month changes in pulmonary, nutritional, metabolic and inflammatory markers in people with CF (PwCF) homozygous for F508del.
Nicola Perrotta, Luigi Angelo Fiorito, Roberta Vescovo, Anna Virgilio, Giulia Amato, Giuseppe Cimino   +5 more
wiley   +1 more source

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

Equine Veterinary Journal, EarlyView.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska, Jowita Grzędzicka‐Agko, Paula Kiełbik, Michał Trela, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

The oncogenic role of hepatitis delta virus in hepatocellular carcinoma

JHEP Reports, 2019
Summary Hepatitis delta virus (HDV) is a small defective virus that needs hepatitis B virus (HBV) to replicate and propagate. HDV infection affects 20-40 million people worldwide and pegylated interferon (PegIFN) is the only recommended therapy. There is
M. Puigvehí, Carlos Moctezuma-Velázquez, A. Villanueva, J. Llovet   +3 more
semanticscholar   +1 more source

Delta infection in children with chronic viral hepatitis B

The Turkish Journal of Pediatrics, 1997
The incidence and clinical features of chronic viral hepatitis B associated with the delta infection were studied in 300 children between one and 14 years in age.
O S Makhmudov, F I Inoyatova, B A Kadirov, S U Abdumadjidova   +3 more
doaj  

Global hepatitis B and D community advisory board: expectations, challenges, and lessons learned

Frontiers in Public Health
IntroductionCommunity Advisory Boards (CABs) play an important role in developing and delivering patient-centered care. However, the impact of participation on CAB members has not been well studied, particularly on the global scale.
Fiona Borondy-Jenkins, Bright Ansah, Jacki Chen, Amanda Goldring, Yasmin Ibrahim, Shaibu Issa, Silvana Lesidrenska, Tanya Machado, Holly Moore, Richard Njouom, Prince Okinedo, Rhea Racho, Lori Scott, Beatrice Zovich, Chari Cohen   +14 more
doaj   +1 more source