Results 81 to 90 of about 1,159,378 (230)

Polyphyllin I Alleviates Alcoholic Liver Disease via Modulation of the Phosphodiesterase 6D–Cyclic Guanosine Monophosphate–Protein Kinase G Axis

Phytotherapy Research, EarlyView.
ABSTRACT Alcoholic liver disease (ALD) is a multifaceted disorder in which oxidative injury, iron‐dependent ferroptosis, steatosis, and inflammation are closely intertwined. Consequently, therapeutic strategies targeting a single pathway often produce limited clinical benefits.
Hongyan Feng, Xuelian Yuan, Yawen Xie, Zhenni Xia, Zhaohui Guo, Xuesong Liu, Rong Li, Wenliang Wang   +7 more
wiley   +1 more source

Characterization of the Phosphorylated Forms and the Phosphorylated Residues of Hepatitis Delta Virus Delta Antigens [PDF]

Journal of Virology, 1999
ABSTRACT Hepatitis delta virus (HDV) replication requires both the cellular RNA polymerase and one virus-encoded protein, small delta antigen (S-HDAg). S-HDAg has been shown to be a phosphoprotein, but its phosphorylation status is not yet clear. In this study, we employed three methods to address this question.
J J, Mu, H L, Wu, B L, Chiang, R P, Chang, D S, Chen, P J, Chen   +5 more
openaire   +2 more sources

Distinct Gene Expression Profiles of Ara h 2‐Specific B Cells in Desensitization and Tolerance During Peanut Oral Immunotherapy

Allergy, EarlyView.
Gene expression of Ara h 2‐specific B cells over the course of the peanut OIT. Isotype of allergen‐specific B cells changes through OIT towards IgG4. Peanut OIT changes the gene expression of allergen‐specific memory B cells. OIT patients showed increased gene expression for regulatory B cells and immune regulation.
Stephan R. Schneider, Juan‐Felipe López, Huseyn Babayev, Willem van de Veen, Minglin Yang, Cezmi A. Akdis, Kari Nadeau, Carolyn H. Baloh, Stacie M. Jones, Lisa M. Wheatley, Mübeccel Akdis, IMPACT, Amy M. Scurlock, D. Pesek, Joy Laurienzo‐Panza, Marshall Plaut, A. Wesley Burks, Edwin H. Kim, Mike Kulis, Anna Nowak‐Wegrzyn, Hugh A. Sampson, Julie Wang, Robert A. Wood, Sharon Chinthrajah, Robert Sayantani B. Sindher, Jacqueline Johnson, Katharine Spain, Denise C. Babineau, Hyunsook Chin, Rachel Yan, Don Whitehouse, Michelle L. Sever, Srinath Sanda, David Larson, Tielin Qin, Gina Marchesini, Kavitha Gilroy, Sylvia Posso, Sabrina Skiba, Thien‐Son Nguyen, Adam Wojno, Tuan Nguyen, Vivian Gersuk, Quynh‐Anh Nguyen, Jessica Garber, Kimberly O'Brien, Brandon Larson, C. Cousens‐Jacobs, Alex Hu   +48 more
wiley   +1 more source

Treatment of Chronic Delta Hepatitis: A Nine-Year Retrospective Analysis

, 2011
Background: Chronic delta hepatitis is the most severe form of viral hepatitis, for which interferon administration is the only available treatment. However, the efficacy of interferon treatment is affected by the dose and duration of treatment, and ...
Tekin, Recep, Bozkurt, Fatma, Serda Gulsun, Recep Tekin, Fatma Bozkurt, Gulsun, Serda   +5 more
core   +1 more source

Carriage of the Laboratory of Genetics and Physiology Protein 2 Q425R Variant Reduces Liver Disease Severity in European Patients With Chronic Hepatitis Delta

Alimentary Pharmacology &Therapeutics, EarlyView.
In patients with chronic hepatitis Delta, the LGP2 Q425R variant (rs2074158 CC/CT genotypes), associated with an enhanced interferon response in vitro, becomes progressively less frequent as liver disease advances from no cirrhosis to cirrhosis, and to cirrhosis with progressive increase of portal hypertension evaluated by thrombocytopenia.
Sara Cmet, Elisabetta Degasperi, Annarosa Cussigh, Elisabetta Fontanini, Maria Paola Anolli, Floriana Facchetti, Riccardo Perbellini, Dana Sambarino, Sara Colonia Uceda Renteria, Annapaola Callegaro, Davide Bitetto, Elisa Fumolo, Ezio Fornasiere, Elena Garlatti Costa, Edmondo Falleti, Pietro Lampertico, Pierluigi Toniutto   +16 more
wiley   +1 more source

Evolving insights into viral hepatitis: Advances, evidence, and expert perspectives from the ESCMID Study Group for Viral Hepatitis (ESGVH) \u2013 Part 2: hepatitis B, C, and delta [PDF]

Hepatitis B virus (HBV), hepatitis delta virus (HDV), and hepatitis C virus (HCV) remain leading drivers of chronic viral hepatitis, cirrhosis, hepatocellular carcinoma, and liver-related mortality.
Gülşen Özkaya Şahin, Mario U Mondelli, Săndulescu, Oana, Özkaya Şahin, Gülşen, Zidovec-Lepej, Snjezana, Widell, Anders, Oana Săndulescu, Federico Garcia, Snjezana Zidovec-Lepej, Garcia, Federico, Matičič, Mojca, Mojca Matičič, Anders Widell, Irving, William, William Irving, Mondelli, Mario U., Marianne Alanko Blomé, Alanko Blomé, Marianne, Garcia, Federico,, ESCMID Study Group for Viral Hepatitis (ESGVH), Mondelli, Mario U.,, Blom\ue9, Marianne Alanko, S\u103ndulescu, Oana, Şahin, Gülşen Özkaya, Şahin, Gülşen Özkaya,, Săndulescu, Oana,, Matičič, Mojca,, Blomé, Marianne Alanko, Mondelli, Mario U, \u15eahin, G\ufcl\u15fen 6zkaya, ESCMID Study Group for Viral Hepatitis (ESGVH),, Mati\u10di\u10d, Mojca, Mondelli, Mario, Blomé, Marianne Alanko,, Lund University., Irving, William,, Widell, Anders,   +36 more
core   +1 more source

Contribution of endosomal proteins EHD1 and EHD4 to the HIV‐1 replication cycle

The FEBS Journal, EarlyView.
EHD1 and EHD4, two key trafficking proteins, regulate multiple stages of HIV‐1 infection: In producer cells, they help produce fully infectious virus particles, regulate Envelope protein incorporation in a cell‐type‐dependent manner, and limit the accumulation of antiviral IFITM proteins in virions.
Grégory Pacini, Konstantinos Poalas, Margaux Versapuech, Clarisse Berlioz‐Torrent, Katy Janvier   +4 more
wiley   +1 more source

Long\u2010term outcome of hepatitis delta in different regions world\u2010wide : results of the Hepatitis Delta International Network

: Background and Aims Chronic hepatitis delta represents a major global health burden. Clinical features of hepatitis D virus (HDV) infection vary largely between different regions worldwide.
Ceausu, Emanoil, Gherlan, George, Wranke, Anika, Keskin, Onur, Wedemeyer, Heiner, Buti, Maria, Turcanu, Adela, Vanwolleghem, Thomas, Niro, Grazia A., Ingiliz, Patrick, D\uf6rge, Petra, Yurdaydin, Cihan, Lobato, Cirley, Jachs, Mathias, Rizzetto, Mario, Dalekos, George N., Cornberg, Markus, Muche, Marion, Abbas, Minaam, Abbas, Zaigham   +19 more
core   +1 more source

Cloning and expression of an immunodominant region of the hepatitis delta antigen

Journal of General Virology, 1990
A cDNA clone prepared from hepatitis delta virus (HDV) RNA extracted from human serum was subcloned in the bacterial expression vector pPL31 to produce a fusion protein consisting of the first 98 amino acids of MS2 polymerase and of 64 amino acids from near the N-terminal region of hepatitis delta antigen (HDAg).
J, Saldanha, E, Homer, R, Goldin, H C, Thomas, J, Monjardino   +4 more
openaire   +2 more sources

Antibiotic‐mediated immune modulation in periodontitis

Periodontology 2000, EarlyView.
Abstract Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth. Although initiated by dysbiotic microbial communities, its progression is largely driven by the host's uncontrolled inflammatory response. While antibiotics have conventionally been employed in periodontitis therapy for their antimicrobial ...
Lina J. Suárez, R. M. Arce, Camila Pinheiro Furquim, Cristiane Gonçalves, Alpdogan Kantarci, Magda Feres, Nidia C. Castro dos Santos   +6 more
wiley   +1 more source