Results 61 to 70 of about 1,159,378 (230)

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

Changes in viral load and HBsAg and HBeAg status with age in HBV chronic carriers in The Gambia. [PDF]

, 2008
BACKGROUND: Little is known about changes in hepatitis B viral load (HBV DNA) in relation to age in Africa. The aim of this study is to determine the natural course of HBV chronic infection, particularly in relation to sequential changes in serum HBV DNA
Jeffries, David, Kaye, Steve, Hilton C. Whittle (7946705), David Jeffries, Maimuna E Mendy, Samuel J McConkey, Steve Kaye, Samuel McConkey (7896113), Marianne AB Sande van der (7946780), Kaye Steve, Mendy, Maimuna E, Maimuna E. Mendy (7946657), Hall, Andrew J, Mendy Maimuna E, Andrew J Hall, Crozier, Sarah, McConkey, Samuel J, Sarah Crozier (46005), Sande van der, Marianne AB, Steve Kaye (46006), Whittle, Hilton C, Andrew J. Hall (78002), Whittle Hilton C, Sande van der Marianne AB, Hilton C Whittle, Marianne AB Sande van der, David Jeffries (46007), Sarah Crozier, Jeffries David, McConkey Samuel J, Hall Andrew J, Crozier Sarah   +31 more
core   +1 more source

Predominance of HBV Genotype B and HDV Genotype 1 in Vietnamese Patients with Chronic Hepatitis

Viruses, 2021
Hepatitis delta virus (HDV) coinfection will additionally aggravate the hepatitis B virus (HBV) burden in the coming decades, with an increase in HBV-related liver diseases.
Nghiem Xuan Hoan, Mirjam Hoechel, Alexandru Tomazatos, Chu Xuan Anh, Srinivas Reddy Pallerla, Le Thi Kieu Linh, Mai Thanh Binh, Bui Tien Sy, Nguyen Linh Toan, Heiner Wedemeyer, C.-Thomas Bock, Peter G. Kremsner, Christian G. Meyer, Le Huu Song, Thirumalaisamy P. Velavan   +14 more
doaj   +1 more source

A practical difference from the normal approach to evaluate natural killer (NK) cells and NK cell neoplasms by flow cytometry

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Natural killer (NK) cell neoplasms span indolent to highly aggressive entities, and flow cytometric immunophenotyping is central to their detection and classification. However, distinguishing reactive from neoplastic NK cell expansions can be challenging because NK cells lack somatically recombined antigen receptors, and reactive states may ...
Aaron J. Wilk, Afshin Shameli, Erik Ames, Jonathan R. Fromm, Bartosz Grzywacz, Min Shi, Sindhu Cherian, Jean Oak   +7 more
wiley   +1 more source

Transmission of the hepatitis B virus-associated delta antigen to chimpanzees

, 1980
Inoculation of hepatitis B surface antigen (HBsAg)-positive sera from patients with chronic liver disease and intrahepatic delta (d) into chimpanzees susceptible to infection with hepatitis B virus (HBV) resulted in type B hepatitis and d markers (d ...
J. L. Gerin, W. T. London, D. L. Sly, R. H. Purcell, M. G. Canese, M. Rizzetto   +5 more
core   +1 more source

Structure and replication of hepatitis delta virus [PDF]

, 2010
Hepatitis delta virus is the causative agent of one of the most severe forms of human virus hepatitis. It is a small and simple pathogen whose genome consists of a single RNA molecule of 1.7 Kb that encodes for only one antigen.
Cunha, C
core   +1 more source

Subset‐specific and tissue‐specific expression of NK‐cell markers and killer immunoglobulin‐like receptors: Implications for NK‐cell clonality assessment

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Accurate immunophenotypic evaluation of natural killer (NK)‐cell neoplasms is challenging because NK‐cells lack somatically rearranged antigen receptors, are comprised of phenotypically distinct subsets, and exhibit tissue‐specific subset distribution. We developed a flow cytometry (FC) panel for NK‐cell immunophenotypic analysis and clonality
Valerie Woodings, Orrin Koepke, Jason E. Love, Alireza Torabi, Lianqun Qiu, Jonathan R. Fromm, Sindhu Cherian, Afshin Shameli   +7 more
wiley   +1 more source

Circulating hepatitis B surface antigen particles carry hepatocellular microRNAs. [PDF]

PLoS ONE, 2012
Hepatitis B virus (HBV) produces high quantities of subviral surface antigen particles (HBsAg) which circulate in the blood outnumbering virions of about 1\10(3-6) times.
Luisa Novellino, Riccardo L Rossi, Ferruccio Bonino, Daniela Cavallone, Sergio Abrignani, Massimiliano Pagani, Maurizia R Brunetto   +6 more
doaj   +1 more source

Role of RNA Polymerase II Promoter-Proximal Pausing in Viral Transcription

Viruses, 2022
The promoter-proximal pause induced by the binding of the DRB sensitivity-inducing factor (DSIF) and the negative elongation factor (NELF) to RNAP II is a key step in the regulation of metazoan gene expression.
Marilyn Whelan, Martin Pelchat
doaj   +1 more source

Physical Activity and Risk of Liver Cancer: A Competing Risk Analysis

International Journal of Cancer, EarlyView.
ABSTRACT Physical activity is associated with lower risk of liver cancer, but obtaining an unbiased estimate of the causal effect is challenging due to the competing risk of death due to any other cause. We performed a causal competing risk analysis to estimate the total effect of physical activity on risk of liver cancer in the presence of competing ...
Frances E. M. Albers, S. Ghazaleh Dashti, Charles E. Matthews, Lin Yang, Darren R. Brenner, Linda M. Liao, Roger L. Milne, Dallas R. English, Katherine A. McGlynn, Brigid M. Lynch   +9 more
wiley   +1 more source