Results 1 to 10 of about 20,901 (137)

Proteins and peptides as antigen candidates for the immunodiagnosis of hepatitis D [PDF]

Amino Acids
Designing innovative, accurate, universal, and accessible diagnostic tests is mandatory to improve screening, prevention, and management of hepatitis D (HD), especially in endemic areas with poor infrastructure and restricted access to public health care.
Sandra Rodrigues Xavier, Isabelle Caroline dos Santos Barcelos, Isadora Braga Gandra, Sabrina Paula Pereira, Anna Julia Ribeiro, Kamila Alves Silva, Carlos Ananias Aparecido Resende, Lucas da Silva Lopes, Rafaela Camargo Rodrigues Machado, Leonardo Maciel Santos Silva, Líria Souza Silva, Lívia Corrêa Ferreira, Luiz Fellype Alves de Souza, Rutilene Barbosa Souza, Ana Maísa Passos-Silva, Mariana Campos da Paz, Miguel Angel Chávez Fumagalli, Eduardo Antônio Ferraz Coelho, Rodolfo Cordeiro Giunchetti, Juliana Martins Machado, Ana Alice Maia Gonçalves, Soraya dos Santos Pereira, Daniel Archimedes da Matta, Deusilene Souza Vieira, Alexsandro Sobreira Galdino   +24 more
doaj   +2 more sources

Differential impact of hepatitis delta virus replication and expression of viral antigens on the cellular kinome profile [PDF]

Cell Communication and Signaling
Background An infection with hepatitis D virus (HDV) is considered the most extreme form of viral hepatitis. Infection with HDV elicits strong increases in inflammation and hepatic injury, therefore pushing liver cirrhosis and development of ...
Keerthihan Thiyagarajah, Mirco Glitscher, Kai-Henrik Peiffer, Eberhard Hildt   +3 more
doaj   +2 more sources

Blocking entry of hepatitis B and D viruses to hepatocytes as a novel immunotherapy for treating chronic infections [PDF]

, 2021
Background. Chronic hepatitis B and D virus (HBV/HDV) infections can cause cancer. Current HBV therapy using nucleoside analogues (NAs) is life-long and reduces but does not eliminate the risk of cancer.
Ahlén, G, Frelin, L, Jagya, N, Johansson, M, Maravelia, P, Meuleman, Philip, Ni, Y, Pasetto, A, Pater, L, Pérez, NC, Sällberg, M, Urban, S, Verch, G, Verhoye, Lieven   +13 more
core   +1 more source

Predominance of HBV Genotype B and HDV Genotype 1 in Vietnamese Patients with Chronic Hepatitis

Viruses, 2021
Hepatitis delta virus (HDV) coinfection will additionally aggravate the hepatitis B virus (HBV) burden in the coming decades, with an increase in HBV-related liver diseases.
Nghiem Xuan Hoan, Mirjam Hoechel, Alexandru Tomazatos, Chu Xuan Anh, Srinivas Reddy Pallerla, Le Thi Kieu Linh, Mai Thanh Binh, Bui Tien Sy, Nguyen Linh Toan, Heiner Wedemeyer, C.-Thomas Bock, Peter G. Kremsner, Christian G. Meyer, Le Huu Song, Thirumalaisamy P. Velavan   +14 more
doaj   +1 more source

Hepatitis Delta Virus (HDV) and Delta-Like Agents: Insights Into Their Origin

Frontiers in Microbiology, 2021
Hepatitis delta virus (HDV) is a human pathogen, and the only known species in the genus Deltavirus. HDV is a satellite virus and depends on the hepatitis B virus (HBV) for packaging, release, and transmission.
Hans J. Netter, Hans J. Netter, Marilou H. Barrios, Marilou H. Barrios, Margaret Littlejohn, Lilly K. W. Yuen   +5 more
doaj   +1 more source

Evidence of an Exponential Decay Pattern of the Hepatitis Delta Virus Evolution Rate and Fluctuations in Quasispecies Complexity in Long-Term Studies of Chronic Delta Infection. [PDF]

PLoS ONE, 2016
Chronic HDV infection can cause a severe form of viral hepatitis for which there is no specific treatment. Characterization of the hepatitis B or C viral quasispecies has provided insight into treatment failure and disease recurrence following liver ...
Maria Homs, Francisco Rodriguez-Frias, Josep Gregori, Alicia Ruiz, Pilar Reimundo, Rosario Casillas, David Tabernero, Cristina Godoy, Salma Barakat, Josep Quer, Mar Riveiro-Barciela, Michael Roggendorf, Rafael Esteban, Maria Buti   +13 more
doaj   +1 more source

Ubiquitinated Hepatitis D Antigen-Loaded Microvesicles Induce a Potent Specific Cellular Immune Response to Inhibit HDV Replication in Vivo

Microbiology Spectrum, 2021
Hepatitis D is the most severe form of human viral hepatitis and currently lacks an efficient therapy. Dendritic cell-derived exosomes (Dexs) have been found to induce immune responses capable of eliminating viruses. However, the therapeutic potential of
Ting Yao, Mengjiao Lv, Siyuan Ma, Jinmei Chen, Yi Zhang, Yongsheng Yu, Guoqing Zang, Xiaohua Chen   +7 more
doaj   +1 more source

TNF-alpha inhibition ameliorates HDV-induced liver damage in a mouse model of acute severe infection

JHEP Reports, 2020
Background & Aims: HDV infection induces the most severe form of human viral hepatitis. However, the specific reasons for the severity of the disease remain unknown.
Carla Usai, Sheila Maestro, Gracian Camps, Cristina Olague, Lester Suárez-Amaran, Africa Vales, Tomas Aragon, Mirja Hommel, Rafael Aldabe, Gloria Gonzalez-Aseguinolaza   +9 more
doaj   +1 more source

Hepatitis Delta Virus Antigens Trigger Oxidative Stress, Activate Antioxidant Nrf2/ARE Pathway, and Induce Unfolded Protein Response

Antioxidants, 2023
Hepatitis delta virus (HDV) is a viroid-like satellite that may co-infect individuals together with hepatitis B virus (HBV), as well as cause superinfection by infecting patients with chronic hepatitis B (CHB).
Olga A. Smirnova, Olga N. Ivanova, Furkat Mukhtarov, Vladimir T. Valuev-Elliston, Artemy P. Fedulov, Petr M. Rubtsov, Natalia F. Zakirova, Sergey N. Kochetkov, Birke Bartosch, Alexander V. Ivanov   +9 more
doaj   +1 more source

Statin inhibits large hepatitis delta antigen-Smad3 -twist-mediated epithelial-to-mesenchymal transition and hepatitis D virus secretion

Journal of Biomedical Science, 2020
Background Hepatitis D virus (HDV) infection may induce fulminant hepatitis in chronic hepatitis B patients (CHB) or rapid progression of CHB to cirrhosis or hepatocellular carcinoma. There is no effective treatment for HDV infection.
Yuh-Jin Liang, Cheng-Pu Sun, Yu-Chen Hsu, Yi-Wen Chen, I-An Wang, Chien-Wei Su, Mi-Hua Tao, Jaw-Ching Wu   +7 more
doaj   +1 more source