Results 71 to 80 of about 823,470 (204)

Mucosal‐Associated Invariant T Cells in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao, Feng‐Mi Ou, Dan Liang, Yang Gao, Qing‐Qing Li, Yi‐Qun Kuang   +5 more
wiley   +1 more source

Tracking the source of the hepatitis B virus-specific CD8 T cells during lamivudine treatment [PDF]

, 2003
Lamivudine treatment in chronic hepatitis B leads to the reconstitution of virus-specific T cells in the circulation, but it is not clear whether this is the preferential result of T cell efflux from the liver or lymph nodes.
Gotto, J, Williams, R, Webster, GJM, Dusheiko, GM, Bertoletti, A, Malacarne, F, Reignat, S, Behboudi, S, Burroughs, AK   +8 more
core  

Optimized Ex Vivo Human Liver Slice Culture Maintains Extended Viability and Function for Hepatotoxicity Testing

Advanced Science, Volume 13, Issue 52, 18 September 2026.
An optimized ex vivo human liver slice culture system preserves tissue architecture, hepatocyte function, and immune‐stromal complexity for at least five days. By refining slice thickness, oxygenation, air‐liquid interface, and extracellular matrix support, the platform enables human‐relevant hepatotoxicity testing and mechanistic studies, offering a ...
Huiche Feng, Cinzia Esposito, Andrej Benjak, Matthias S. Matter, Miriam Cieri, Camilla De Carlo, Philipp Sedlaczek, Fabian Haak, Mattia Marinucci, Gabriel Fridolin Hess, Otto Kollmar, Mairene Coto‐Llerena, Luca Di Tommaso, Visar Vela, Lukas Bubendorf, Luigi M. Terracciano, Charlotte K. Y. Ng, Salvatore Piscuoglio   +17 more
wiley   +1 more source

Seroprevalence of hepatitis B and C virus in HIV-1 and HIV-2 infected Gambians. [PDF]

, 2010
BACKGROUND: The prevalence of HIV/hepatitis co-infection in sub-Saharan Africa is not well documented, while both HIV and HBV are endemic in this area.
Jobarteh Modou, Mendy Maimuna, Cotten Matt, Cotten, M, Alabi, A, Tedder, Richard, Sarge-Njie Ramu, Peterson, Ingrid, Whittle, H, Jaye, A, Peterson Ingrid, Richard Tedder, Rowland-Jones, Sarah, Malfroy Marine, Peterson, K, Maimuna Mendy, Jobarteh, Modou, Cotten, Matt, Tedder Richard, Malfroy, M, Peterson, I, Hilton Whittle, Matt Cotten, Sarge-Njie, Ramu, Sarah Rowland-Jones, Ingrid Peterson, Hall, A, Peterson, Kevin, Peterson Kevin, Jaye Assan, Jaye, Assan, Tedder, R, Mendy, Maimuna, Whittle Hilton, Modou Jobarteh, Hall, Andrew, Hall Andrew, Jeng Adam, Alabi, Abraham, Ramu Sarge-Njie, Malfroy, Marine, Mendy, M, Alabi Abraham, Assan Jaye, Whittle, Hilton, Jeng, A, Adam Jeng, Rowland-Jones Sarah, Jobarteh, M, Andrew Hall, Jeng, Adam, Kevin Peterson, Marine Malfroy, Abraham Alabi, Sarge-Njie, R, Rowland-Jones, S   +55 more
core   +1 more source

Differential impact of hepatitis delta virus replication and expression of viral antigens on the cellular kinome profile

Cell Communication and Signaling
Background An infection with hepatitis D virus (HDV) is considered the most extreme form of viral hepatitis. Infection with HDV elicits strong increases in inflammation and hepatic injury, therefore pushing liver cirrhosis and development of ...
Keerthihan Thiyagarajah, Mirco Glitscher, Kai-Henrik Peiffer, Eberhard Hildt   +3 more
doaj   +1 more source

Cumulative Antigen Suppression Reduces Clonal Plasma Cell Evolution in Gaucher Disease

American Journal of Hematology, Volume 101, Issue 9, Page 2197-2213, September 2026.
ABSTRACT Chronic antigenic stimulation is implicated in the pathogenesis of monoclonal gammopathy and multiple myeloma, yet longitudinal human evidence linking sustained antigen exposure to modifiable clonal plasma cell evolution remains limited. Gaucher disease (GD), caused by biallelic GBA1 pathogenic variants, is characterized by accumulation of ...
Noor Ul Ain, Noffar Bar, Lilu Guo, Katherine Klinger, Punita Gupta, Atta Ur Rahman, Ruhua Yang, Yanhong Deng, Natalia Neparidze, Shiny Nair, Pramod K. Mistry   +10 more
wiley   +1 more source

Intrinsic disorder and oligomerization of the hepatitis delta virus antigen

Virology, 2010
The 195 amino acid basic protein (δAg) of hepatitis delta virus (HDV) is essential for replication of the HDV RNA genome. Numerous properties have been mapped to full-length δAg and attempts made to link these to secondary, tertiary and quaternary structures.
Alves, Carolina, Cheng, Hong, Roder, Heinrich, Taylor, John   +3 more
openaire   +2 more sources

Histone Post‐Translational Modifications Regulating Ferroptosis: The Molecular Mechanisms and Disease Associations

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Ferroptosis is a form of programmed cell death characterized by iron‐dependent phospholipid peroxidation and is implicated in a wide range of human diseases. Emerging evidence highlights the critical role of epigenetic regulation in this process.
Xiaoqian Tang, Haodang Luo, Siqi Gao, Xiaocheng Liu, Qing Sun, Yanhua Zeng   +5 more
wiley   +1 more source

Distinct cytokine patterns in Occult Hepatitis C and Chronic Hepatitis C Virus Infection [PDF]

, 2011
Background & Aim: The immunopathogenesis of chronic hepatitis C virus (HCV) infection is a matter of great controversy. The imbalance of T-helper lymphocyte cell cytokine production was believed to play an important pathogenic role in ...
Nashwa Abousamra, Azza Azza Abdel-Aziz, Mona Elhadidy, Mohamed Abd-elmaksoud, Yahia Gad, Nasser Mousa   +5 more
core  

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

Equine Veterinary Journal, Volume 58, Issue 5, Page 1413-1444, September 2026.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska, Jowita Grzędzicka‐Agko, Paula Kiełbik, Michał Trela, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source