Results 51 to 60 of about 140,561 (343)

Immunotherapy in hepatocellular carcinoma: the complex interface between inflammation, fibrosis, and the immune response. [PDF]

, 2019
Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide and confers a poor prognosis. Beyond standard systemic therapy with multikinase inhibitors, recent studies demonstrate the potential for robust and durable responses ...
Fong, Lawrence, Keenan, Bridget P, Kelley, Robin K   +2 more
core   +2 more sources

Protein glycosylation as a diagnostic and prognostic marker of chronic inflammatory gastrointestinal and liver diseases [PDF]

, 2020
Glycans are sequences of carbohydrates that are added to proteins or lipids to modulate their structure and function. Glycans modify proteins required for regulation of immune cells, and alterations have been associated with inflammatory conditions.
Callewaert, Nico, Colombel, Jean-Frederic, Dias, Ana M, Pinho, Salome S, Van Vlierberghe, Hans, Verhelst, Xavier, Vermeire, Severine   +6 more
core   +1 more source

TNFα induces Ca2+ influx to accelerate extrinsic apoptosis in hepatocellular carcinoma cells [PDF]

, 2018
BACKGROUND: Tumor necrosis factor-α has been proven an effective anticancer agent in preclinical studies. However, the translation of TNFα from research to clinic has been blocked by significant systemic toxicity and limited efficacy at maximal tolerated
Ji, Xiaoying, Jin, Mingpeng, Li, Deyang, Ren, Tingting, Wang, Jiaojiao, Wu, Yousheng, Xing, Jinliang, Yang, Hushan, Yin, Chun, Zhang, Hui, Zhu, Jianjun   +10 more
core   +4 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Hepatoprotective Effect of Cocoa Polyphenols on Liver Histopathology in Diabetic Rats

Amerta Nutrition
Background: Diabetes mellitus is a growing global health concern, including in Indonesia, where its prevalence continues to rise. Persistent hyperglycemia and the resulting oxidative stress contribute to hepatic injury, including steatosis and ...
Arisanty Nur Setia Restuti, Adhiningsih Yulianti, Putri Rahayu Ratri   +2 more
doaj   +1 more source

Angiogenic inflammation and formation of necrosis in the tumor microenvironment influence patient survival after radical surgery for de novo hepatocellular carcinoma in non-cirrhosis

World Journal of Surgical Oncology, 2019
Background Tumor escape mechanisms mediated in the tumor microenvironment can significantly reduce the capacity of the anti-tumor function of the immune system. TIE2-expressing monocytes (TEMs), related angiopoietins, and tumor necrosis are considered to
Georgi Atanasov, Karoline Dino, Katrin Schierle, Corinna Dietel, Gabriela Aust, Johann Pratschke, Daniel Seehofer, Moritz Schmelzle, Hans-Michael Hau   +8 more
doaj   +1 more source

AETIOLOGICAL AND PATHOLOGICAL STUDY ON OVINE AND CAPRING ABORTED FOETI

The Iraqi Journal of Veterinary Medicine, 1992
Bacteriological and histopathological investigations were conducted on ovine and caprine aborted foeti, ten each, collected from different parts of Iraq, to determine the posible etiology of abortion and to characterize the histopathological changes ...
A. M. AL-Darraji, S. H. Dhahir, M. J. Alwan   +2 more
doaj   +1 more source

Pertussis toxin, an inhibitor of G(αi) PCR, inhibits bile acid- and cytokine-induced apoptosis in primary rat hepatocytes. [PDF]

PLoS ONE, 2012
Excessive hepatocyte apoptosis is a common event in acute and chronic liver diseases leading to loss of functional liver tissue. Approaches to prevent apoptosis have therefore high potential for the treatment of liver disease. G-protein coupled receptors
Golnar Karimian, Manon Buist-Homan, Klaas Nico Faber, Han Moshage   +3 more
doaj   +1 more source

Tolerance and safety evaluation of N, N-dimethylglycine, a naturally occurring organic compound, as a feed additive in broiler diets [PDF]

, 2009
N, N-dimethylglycine (DMG) is a tertiary amino acid that naturally occurs as an intermediate metabolite in choline-to-glycine metabolism. The objective of the present trial was to evaluate tolerance, safety and bioaccumulation of dietary DMG in broilers ...
Kalmar, I.D., Verstegen, M.W.A., Maenner, K., Zentek, J., Meulemans, G., Janssens, G.P.J.   +5 more
core   +1 more source