Results 61 to 70 of about 140,561 (343)

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Preoperative Balloon-Occluded Transcatheter Arterial Chemoembolization Followed by Surgical Resection: Pathological Evaluation of Necrosis

Diseases, 2023
This study investigates the clinical and pathological outcomes of preoperative balloon-occluded transcatheter arterial chemoembolization (B-TACE) in patients with single hepatocellular carcinoma (HCC).
Jihoon Kim, Dong Il Gwon, Yonghun Kim, Gun Ha Kim, Seong Ho Kim, Hee Ho Chu, Jin Hyoung Kim, Ji Hoon Shin, Gi-Young Ko, Hyun-Ki Yoon   +9 more
doaj   +1 more source

Loss of ATF3 exacerbates liver damage through the activation of mTOR/p70S6K/ HIF-1α signaling pathway in liver inflammatory injury. [PDF]

, 2018
Activating transcription factor 3 (ATF3) is a stress-induced transcription factor that plays important roles in regulating immune and metabolic homeostasis.
Jiang, Bin, Jiang, Longfeng, Ke, Bibo, Li, Changyong, Lu, Ling, Ni, Xuhao, Wang, Han, Wang, Xuehao, Zhang, Feng, Zhu, Qiang   +9 more
core   +2 more sources

Development of a Prediction Model for Progression Risk in High‐Grade Gliomas Based on Habitat Radiomics and Pathomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate the value of constructing models based on habitat radiomics and pathomics for predicting the risk of progression in high‐grade gliomas. Methods This study conducted a retrospective analysis of preoperative magnetic resonance (MR) images and pathological sections from 72 patients diagnosed with high‐grade gliomas (52 ...
Yuchen Zhu, Yuxi Gong, Weilin Xu, Xingjian Sun, Gefei Jiang, Lei Qiu, Kexin Shi, Mengxing Wu, Yinjiao Fei, Jinling Yuan, Jinyan Luo, Yurong Li, Yuandong Cao, Minhong Pan, Shu Zhou   +14 more
wiley   +1 more source

Mechanisms of cell death in acute liver failure

Frontiers in Physiology, 2012
Acute liver failure (ALF) occurs when the extent of hepatocyte death exceeds the regenerative capacity of the liver. The mode of liver cell death that is predominantly induced in ALF, i.e.
Heike eBantel
doaj   +1 more source

Evaluation of Hepatocellular Carcinoma Transarterial Chemoembolization using Quantitative Analysis of 2D and 3D Real-time Contrast Enhanced Ultrasound. [PDF]

, 2018
Quantitative 2D and 3D contrast-enhanced ultrasound (CEUS) was assessed to evaluate early transarterial chemoembolization (TACE) treatment response. Seventeen patients scheduled for TACE for the treatment of hepatocellular carcinoma participated in the ...
Eisenbrey, John R., Forsberg, Flemming, Kono, Yuko, Lyshchik, Andrej, Machado, Priscilla, Nam, Kibo, Shaw, Colette M., Stanczak, Maria   +7 more
core   +1 more source

Clinicopathological and targeted exome gene features of a patient with metastatic acinic cell carcinoma of the parotid gland harboring an ARID2 nonsense mutation and CDKN2A/B deletion [PDF]

, 2015
We describe the presentation, treatment, clinical outcome, and targeted genome analysis of a metastatic salivary acinic cell carcinoma (AciCC). A 71-year-old male presented with a 3 cm right tail of a parotid lesion, first detected as a nodule by the ...
Momand, Jamil, Palma-Diaz, Fernando, Shibuya, Terry Y, Warner, Wayne A, Wong, Deborah J   +4 more
core   +4 more sources

A CASE OF SPONTANEOUS COMPLETE NECROSIS OF HEPATOCELLULAR CARCINOMA

Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association), 2006
自然壊死をきたした稀な肝細胞癌症例を経験したので報告する.症例は71歳の男性. C型慢性肝炎の診断で近医通院中であった.肝S5領域に腫瘤性病変を認め,肝細胞癌の診断で当科へ紹介入院の後,肝S5の部分切除術を施行した.肉眼的に病変は線維組織で取り囲まれた黄色の結節であり,病理学的所見では内部の組織は完全に壊死に陥っていた.術前の画像所見と腫瘍マーカーの推移に加え,標本の鍍銀染色に細網線維の残存が観察されたことや,抗ヘパトサイト抗体の陽性像などより,この壊死組織は自然壊死をきたした肝細胞癌であると考えられた.その機序として,血管造影に伴う内膜損傷による肝への血流の低下,免疫学的反応の関与が考えられた.文献上,同様な症例は6例であった.
Kazuto SHIBUYA, Tadashi BANDO, Yasuharu ONISHI, Takuya NAGATA, Fuminori YAMAGISHI, Kazuhiro TSUKADA   +5 more
openaire   +2 more sources

Intrinsic Photoactive Star ZnPc–Poly(glutamate) Nanoplatforms for Multimodal Glioblastoma Therapy and Brain‐Targeted Delivery

Advanced Functional Materials, EarlyView.
An intrinsic photoactive star‐shaped zinc phtalocyanine‐poly(L‐glutamic acid) (ZnPc‐PGA) nanoplatform for multimodal glioblastoma (GBM) therapy and brain‐targeted elivery. A ZnPc‐PGA‐based multifunctional theranostic nanocarrier platform enables image‐guided, multimodal GBM therapy. ZnPc‐PGA nanocarriers support the integration of fluorescence imaging,
Amina Benaicha‐Fernández, Teodora Ranđelović, Ana Armiñán, Víctor Sebastián, Manuel Fuentes, Cristián Huck‐Iriart, Esther Masiá, Paula Carrascosa‐Marco, Pablo Juanes‐Velasco, Snežana Đorđević, Clara Bayona, Ignacio Ochoa, Maria Medel, Inmaculada Conejos‐Sánchez, María J. Vicent   +14 more
wiley   +1 more source

Hepatocellular Regeneration and Necrosis Markers in Chronic HCV Patients under Sofosbuvir-Based Regimen

SVU - International Journal of Medical Sciences, 2021
Objectives: To evaluate noninvasive fibrosis markers, retinol binding protein 4 (RBP4), and alpha-feto protein (AFP) in foreseeing liver fibrosis in persistent hepatitis C patients and their correlations with Fibroscan. Materials and Method: Fifty naive
Amr Alnoby*, Abdallah Elaiw Mohamed Ali, Ayman S. yassin, Hanan Mahmoud Fayed, Hasan Sedeek Mahmoud   +4 more
doaj   +1 more source