Results 51 to 60 of about 380,993 (362)

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Critical location of cell viability loss during the cell injection process in hepatocyte transplantation using a rectangular microchannel model

Journal of Biomechanical Science and Engineering, 2017
A sufficient number of functional live hepatocytes delivered to a recipient is necessary for cell therapy. Preventing cell viability loss during the cell injection process is important to improve the clinical outcomes of hepatocyte transplantation.
Sandi SUFIANDI, Hiromichi OBARA, Huai-Che HSU, Shin ENOSAWA, Naoto MATSUNO, Hiroshi MIZUNUMA   +5 more
doaj   +1 more source

T-2 Toxin Induces Oxidative Stress, Apoptosis and Cytoprotective Autophagy in Chicken Hepatocytes

Toxins, 2020
T-2 toxin is type A trichothecenes mycotoxin, which produced by fusarium species in cereal grains. T-2 toxin has been shown to induce a series of toxic effects on the health of human and animal, such as immunosuppression and carcinogenesis.
Huadong Yin, Shunshun Han, Yuqi Chen, Yan Wang, Diyan Li, Qing Zhu   +5 more
doaj   +1 more source

Suitability of hepatocyte cell lines HepG2, AML12 and THLE-2 for investigation of insulin signalling and hepatokine gene expression [PDF]

Open Biology, 2018
Immortal hepatocyte cell lines are widely used to elucidate insulin-dependent signalling pathways and regulation of hepatic metabolism, although the often tumorigenic origin might not represent the metabolic state of healthy hepatocytes.
Stephanie Sefried, Hans-Ulrich Häring, Cora Weigert, Sabine S. Eckstein   +3 more
doaj   +1 more source

EFFECTS OF INSULIN, GLUCAGON, AND INSULIN/GLUCAGON INFUSIONS ON LIVER MORPHOLOGY AND CELL DIVISION AFTER COMPLETE PORTACAVAL SHUNT IN DOGS [PDF]

, 1976
Insulin, glucagon, and insulin/glucagon mixtures have been infused for four days into the left portal vein of dogs after portacaval shunt. In the left but not the right liver lobes, insulin alone reduced atrophy, preserved hepatocyte ultrastructure, and ...
Blackard, Bollman, Bucher, Child, Eck, Felig, Felig, Field, Fisher, Fisher, Hahn, Holley, Izzo, Leffert, Loud, Madison, Mann, Marchioro, Marchioro, Marchioro, Meyer, Popper, Reaven, Rous, Rubin, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Tchobroutsky, Warren, Wembren, Younger   +36 more
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

iPSC-derived hepatocytes generated from NASH donors provide a valuable platform for disease modeling and drug discovery

Biology Open, 2020
Non-alcoholic fatty liver disease (NAFLD) affects 30–40% of adults and 10% of children in the US. About 20% of people with NAFLD develop non-alcoholic steatohepatitis (NASH), which may lead to cirrhosis and liver cancer, and is projected to be a leading ...
Igor Gurevich, Sarah A. Burton, Christie Munn, Makiko Ohshima, Madelyn E. Goedland, Katherine Czysz, Deepika Rajesh   +6 more
doaj   +1 more source

Association of a MET genetic variant with autism-associated maternal autoantibodies to fetal brain proteins and cytokine expression. [PDF]

, 2011
The contribution of peripheral immunity to autism spectrum disorders (ASDs) risk is debated and poorly understood. Some mothers of children with ASD have autoantibodies that react to fetal brain proteins, raising the possibility that a subset of ASD ...
Ashwood, P, Braunschweig, D, Campbell, DB, Heuer, L, Van de Water, J   +4 more
core   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source