Results 171 to 180 of about 34,122,793 (250)

Genetic or pharmacological inhibition of hepatic TMEM141 attenuates MASH and fibrosis via the ROS-HNF4α signaling pathway. [PDF]

Nat Commun
Wang J, Chen CL, Gopoju R, Hu S, Wang Y, Wang H, Batayneh Z, Pan X, Chen YR, Mellott J, Kang P, Gunawardana L, Yin L, Zhang Y.   +13 more
europepmc   +1 more source

Hepatocyte HIF2α Downregulates the Urea Cycle Through Suppression of HNF4α. [PDF]

Gastro Hep Adv
Cantwell MT, El-Derany MO, Reddy Mooli RG, Ramakrishnan SK, Shah YM.   +4 more
europepmc   +1 more source

Neuroprotective effect of normal and modified mesenchymal stem cell‐derived exosomes by mitigating Alzheimer's‐related oxidative and inflammatory damage via Nrf2/HO‐1 in SH‐SY5Y cells

Ibrain, EarlyView.
Exosome therapy shows promise in Alzheimer's disease. This study compared normal and modified exosomes from AD brain extract‐treated MSCs in STZ‐induced SH‐SY5Y cells. Exosomes improved neuronal viability, reduced oxidative stress and inflammation, and activated Nrf2/HO‐1 signaling.
Rishika Dhapola, Prajjwal Sharma, Sneha Kumari, Balachandar Vellingiri, Dibbanti HariKrishnaReddy   +4 more
wiley   +1 more source

Autophagy in MASLD: A Metabolic and Precision Medicine Perspective. [PDF]

Liver Int
Cazzaniga A, Frigo S, Cherubini A, Rrapaj E, Valenti L.   +4 more
europepmc   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Establishment and Characterization of the Murine Liver Tumor Cell Line ΔCN60 with Conditional Caspase-8 and IKKγ/NEMO Inactivation and a Hepatocyte-Biliary Progenitor-like Phenotype. [PDF]

Cells
Cornejo Müller A, Liehr T, Balakrishnan P, Kankel S, Buhl EM, Keller DT, Hardt KS, Schröder-Lange SK, Liedtke C, Weiskirchen R.   +9 more
europepmc   +1 more source

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source

PPARγ-dependent and -independent regulation of genes involved in hepatic methionine cycle in fasted or diet-induced obese mice. [PDF]

PLoS One
Hawro I, Lee SM, Kineman RD, Cordoba-Chacon J.   +3 more
europepmc   +1 more source

ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential

iNew Medicine, EarlyView.
ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang, Xinyan Li, Honglu Shi, Gaolei Song, Zhifu Xie, Jingya Li   +5 more
wiley   +1 more source