Results 231 to 240 of about 79,825 (316)

Hepatocyte nuclear factors dynamically regulate triglyceride metabolic reprogramming in metabolic dysfunction-associated steatotic liver disease: Mechanisms and implications. [PDF]

World J Hepatol
Li SQ, Wu JH, Zhou Y, Wang CX, Xie L, Liu SY, Su YZ, He W, Chen H, Zhong WW, He YH.   +10 more
europepmc   +1 more source

Measuring Propidium Iodide Brightness as a Function of Viability: A High‐Throughput Quantitative Assessment of Hepatic Spheroids

Artificial Organs, EarlyView.
The graphical abstract illustrates our rapid PI‐based spheroid viability assay: hepatocyte spheroids are formed and stained with AO/PI, imaged after a 15‐min incubation, and analyzed for PI brightness normalized to area. This metric correlates strongly with functional urea/DNA output, validating PI intensity as a fast, reliable indicator of spheroid ...
Michael G. Megaly, Diane Tobolt, Bat‐Erdene Namsrai, Benjamin Fisher, Anthony An‐Fa Dahm Chen, Joseph Sushil Rao, Srivasupradha Ramesh, Anudari Chimedtseren, Mark Clemens, Charles Y. Lee, John C. Bischof, Erik B. Finger   +11 more
wiley   +1 more source

Metabolic dysfunction-associated steatotic liver disease, insulin resistance and hepatocellular carcinoma: A deadly triad. [PDF]

Eur J Clin Invest
Caturano A, Erul E, Nilo R, Nilo D, Russo V, Rinaldi L, Acierno C, Akkus E, Koudelkova K, Cerini F, Rizzo A, Sasso FC, Bonfrate L, Giordano A, Yaşar HA, Conte C.   +15 more
europepmc   +1 more source

Sialylation patterns in cerebral amyloid angiopathy

Brain Pathology, EarlyView.
This study is the first to localize and evaluate sialylation modifications in the context of Alzheimer's Disease and Cerebral Amyloid Angiopathy, revealing a unique disease‐specific increase in intravascular sialylation. Abstract Glycosylation is the most common form of post‐translational modification in the brain and becomes significantly altered in ...
Caitlyn Fastenau, Rebecca Crisp, Mallory Keating, Elizabeth Ochoa, Timothy E. Richardson, Margaret E. Flanagan, Jamie M. Walker, Sarah C. Hopp, Kevin F. Bieniek   +8 more
wiley   +1 more source

Iron-related intercellular communication in the liver: Main players and mechanisms. [PDF]

Eur J Clin Invest
Fonseca Ó, Oliveira PJ, Muckenthaler MU, Moreira AC, Gomes MS.   +4 more
europepmc   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Hepatocyte SAMHD1 Deficiency Attenuates Hepatic Steatosis via Suppression of SREBP Activation in a Mouse Model of Metabolic-Associated Steatotic Liver Disease. [PDF]

Int J Biol Sci
Yin G, Liu Y, Teng X, Sun S, Chen B, Wang X, Yang T, Wang Y, Xu H, Chen YS, Gan G, Shen Y, Shao J.   +12 more
europepmc   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

Cell-specific roles of autophagy in liver fibrosis: implications for targeted pharmacotherapy. [PDF]

Ann Med
Liu C, Yang H, Liu Y, An M, Weng Z, Li L.   +5 more
europepmc   +1 more source

Functional Difference of MYC and MYCN in Combined Hepatocellular–Cholangiocarcinoma: Regulation of Differentiation by HNF1B

Cancer Science, EarlyView.
Combined hepatocellular–cholangiocarcinoma (cHCC‐CCA) is a tumor consisting of a mixture of hepatocellular carcinoma and intrahepatic cholangiocarcinoma (CCA) components, but the mechanisms of development are poorly understood. The activation of Myc may be implicated in the formation of cHCC‐CCA and this work demonstrates for the first time that Myc ...
Masanori Goto, Masahiro Yamamoto, Hiroki Tanaka, Yumiko Fujii, Kumi Takasawa, Yuki Kamikokura, Masayo Kamikokura, Nobuyuki Kobayashi, Taro Murakami, Yuji Nishikawa, Akira Takasawa   +10 more
wiley   +1 more source