Results 241 to 250 of about 334,700 (354)

Lipid Nanoparticles for Delivery of CRISPR Gene Editing Components

Small Methods, EarlyView.
The review presents a comprehensive overview of each component of lipid nanoparticles（LNPs）and their effects on editing efficiency. It specifically highlights strategies for achieving non‐liver delivery, aiming for broader applications in gene editing. Furthermore, this review summarizes the applications of LNPs in gene editing and offers insights for ...
Fan Wu, Nei Li, Yudian Xiao, Rohan Palanki, Hannah Yamagata, Michael J. Mitchell, Xuexiang Han   +6 more
wiley   +1 more source

Alcohol-induced gut permeability defect through dysbiosis and enterocytic mitochondrial interference causing pro-inflammatory macrophages in a dose dependent manner. [PDF]

Sci Rep
Chancharoenthana W, Kamolratanakul S, Udompornpitak K, Wannigama DL, Schultz MJ, Leelahavanichkul A.   +5 more
europepmc   +1 more source

Lipid Microparticle‐Based Phantoms Modeling Hepatic Steatosis for the Validation of Quantitative Imaging Techniques

Small Methods, EarlyView.
This paper presents a novel method for creating ultrasound phantoms that accurately replicate fat vesicle sizes encountered in Metabolic Dysfunction‐Associated Steatotic Liver Disease (MASLD). This approach can improve the understanding of liver fat measurement by creating ultrasound phantoms that link different quantitative imaging techniques to ...
Connor Endsley, Shariq Ali, Karim Salhadar, Adam Woodward, Shea Garland, Julien Santelli, Mehdi Zeighami Salimabad, Liqiang Ren, Takeshi Yokoo, Ivan M. Rosado‐Mendez, David T. Fetzer, Caroline de Gracia Lux   +11 more
wiley   +1 more source

The role of ubiquitination and deubiquitination in the pathogenesis of non-alcoholic fatty liver disease. [PDF]

Front Immunol
Zhang L, Liu S, Zhao Q, Liu X, Zhang Q, Liu M, Zhao W.   +6 more
europepmc   +1 more source

Manipulation of Wnt/β‐Catenin Signaling by Synthetic Frizzled Agonist and LRP Antagonist in Organoid Cultures and In Vivo

Small Methods, EarlyView.
Harnessing synthetic key receptor modulators, this study presents a breakthrough in Wnt/β‐catenin regulation. The FZD agonist RRP‐pbFn bypasses LRP5/6 to drive organoid expansion and tissue regeneration, while the LRP antagonist RRP‐Dkk1c eradicates tumors. These tools enable precise pathway control, advancing regenerative and cancer therapies.
Quanhui Dai, Jiawen Wang, Zihuan Lin, Danni Yu, Hui Yang, Jinsong Wei, Xiaoyu Li, Hao Hu, Chao Ni, Bing Zhao   +9 more
wiley   +1 more source

Network pharmacology-based investigation of the pharmacological mechanisms of diosgenin in nonalcoholic steatohepatitis. [PDF]

Sci Rep
Gu P, Chen J, Xin J, Chen H, Zhang R, Chen D, Zhang Y, Shao S.   +7 more
europepmc   +1 more source

Unveiling the complex extra‐oral colonization pathways and pathogenic mechanisms of Fusobacterium nucleatum, a heterogeneous oral pathogen

VIEW, EarlyView.
We summarize the taxonomic characteristics, capabilities to adhere to and invade host cells, extra‐oral ectopic colonization pathways, and major pathogenic mechanisms of Fusobacterium nucleatum, and explore the regulation of F. nucleatum’s pathogenesis, aiming to provide references and assistance for the development of clinical interventions and future
Zhiwei Guan, Houbao Qi, Qiang Feng
wiley   +1 more source

Analysis of the Functional Role of TIMM29 in the Hepatitis B Virus Life Cycle

Microbiology and Immunology, Volume 69, Issue 4, Page 229-246, April 2025.
ABSTRACT Hepatitis B virus (HBV) causes chronic hepatitis B, which can progress to liver cirrhosis and hepatocellular carcinoma. HBV has complex interactions with various cell organelles and proteins that ensure effective progeny virus production. We previously reported that a mitochondrial protein, TIMM29, should regulate the HBV life cycle through ...
Limia Abueldahab, Yadarat Suwanmanee, Nelly Muriungi, Eriko Ohsaki, Masami Wada, Shihoko Kimura‐Ohba, Keiji Ueda   +6 more
wiley   +1 more source

Multiple hepatocyte-enriched nuclear factors function in the regulation of transthyretin and alpha 1-antitrypsin genes.

, 1989
Robert H. Costa, Dennis R. Grayson, James Darnell   +2 more
openalex   +1 more source

Oxidative stress modulation in alcohol-related liver disease: From chinese botanical drugs to exercise-based interventions. [PDF]

Front Pharmacol
Zhu Y, Jia Y, Zhang E.
europepmc   +1 more source