Results 251 to 260 of about 334,700 (354)

Telomere Position Effect‐Over Long Distances Acts as a Genome‐Wide Epigenetic Regulator Through a Common Alu Element

Aging Cell, EarlyView.
Proposed TPE‐OLD model. TPE‐OLD genes are defined by a progressive modulation of gene expression following telomere attrition. In our study, focusing on the molecular mechanism of TPE‐OLD, we found that the TPE‐OLD loop requires a cis‐signature corresponding to a newly evolved Alu repeats (AluY). The Alu repeat can be either in an intergenic region, as
Raphaël Chevalier, Victor Murcia Pienkowski, Nicolas Jullien, Leslie Caron, Pascal Verdier Pinard, Frédérique Magdinier, Jérôme D. Robin   +6 more
wiley   +1 more source

Hepatocyte ALOXE3 is induced during adaptive fasting and enhances insulin sensitivity by activating hepatic PPARγ [PDF]

, 2018
DeBosch, Brian J, Fujiwara, Hideji, Graham, Mark J, Higgins, Cassandra B, Mayer, Allyson L, Stothard, Alicyn I, Swarts, Benjamin M, Zhang, Yiming   +7 more
core   +1 more source

STAT5: Understanding the Biology of KRAS^G12D-Driven Pancreatic Cancer. [PDF]

J Cell Mol Med
Papavassiliou KA, Adamopoulos C, Papavassiliou AG.   +2 more
europepmc   +1 more source

NETosis: A bridge between cancer and autoimmunity

Rheumatology &Autoimmunity, EarlyView.
Niloufar Orooji, Manouchehr Fadaee
wiley   +1 more source

Ecological Realism Accelerates Epigenetic Aging in Mice

Aging Cell, EarlyView.
Living environment shapes mammalian aging, but laboratory conditions lack the ecological realism of natural social, physical, and microbial environments. Comparing traditionally laboratory‐reared and “re‐wilded” C57BL/6J mice, we reveal accelerated, genomic region‐dependent epigenetic aging in the liver under naturalistic field conditions, highlighting
Matthew N. Zipple, Ivan Zhao, Daniel Chang Kuo, Sol Moe Lee, Michael J. Sheehan, Wanding Zhou   +5 more
wiley   +1 more source

Role of mitogens in normal and pathological liver regeneration. [PDF]

Hepatol Commun
Vosough M, Shokouhian B, Sharbaf MA, Solhi R, Heidari Z, Seydi H, Hassan M, Devaraj E, Najimi M.   +8 more
europepmc   +1 more source

Editorial: Hepatocyte nuclear factor 4 alpha - new insights into an old receptor. [PDF]

Front Endocrinol (Lausanne)
Sladek FM, Apte U, Deol P.
europepmc   +1 more source

Extracellular Vesicles miRNome Profiling Reveals miRNAs Engagement in Dysfunctional Lipid Metabolism, Chronic Inflammation and Liver Damage in Subjects With Metabolic Dysfunction‐Associated Steatotic Liver Disease

Alimentary Pharmacology &Therapeutics, EarlyView.
This study explores the association between the miRNome profile of circulating extracellular vesicles and metabolic dysfunction, liver inflammation, and damage in patients with metabolic MASLD, identifying key miRNAs (miR‐122‐5p, miR‐375‐3p, let‐7d‐5p, and let‐7f‐5p) that modulate lipid metabolism and inflammatory pathways in ‘at‐risk MASH’ patients ...
Gian Paolo Caviglia, Elisabetta Casalone, Chiara Rosso, Serena Aneli, Alessandra Allione, Fabrizia Carli, Cristina Grange, Angelo Armandi, Chiara Catalano, Giovanni Birolo, Beatrice Foglia, Davide Giuseppe Ribaldone, Amalia Gastaldelli, Giuseppe Matullo, Elisabetta Bugianesi   +14 more
wiley   +1 more source

Suppression of regulatory factor X 7 alleviates airway remodeling and inflammation in childhood asthma.

Cytojournal
Wu Y, Dai T, Qin J, Guo J, Fan J, Mei J, Li X, Liu F.   +7 more
europepmc   +1 more source

Understanding erythroid physiology and pathology in humanized mice: A closer look

British Journal of Haematology, Volume 206, Issue 5, Page 1272-1284, May 2025.
Erythropoiesis, the formation of red blood cells (RBCs) from haematopoietic stem cells (HSCs), is vital for understanding conditions like anaemia and haemoglobinopathies. However, studying this process in vivo is challenging due to the lack of accurate models.
Lu Lu, Chenfei Liu, Lezong Chen, Xumiao Zhang, Yinglin Su, Zhenzhen Chou, Yang Liang, Yuanbin Song   +7 more
wiley   +1 more source