Results 261 to 270 of about 334,700 (354)

Astrocyte Elevated Gene-1/Metadherin (AEG-1/MTDH): A Promising Molecular Marker and Therapeutic Target for Hepatocellular Carcinoma. [PDF]

Cancers (Basel)
Davis E, Ermi AG, Sarkar D.
europepmc   +1 more source

Innovative pharmacotherapy for hepatic metabolic and chronic inflammatory diseases in China

British Journal of Pharmacology, EarlyView.
Abstract Liver disease constitutes a significant global health concern, particularly in China where it has distinctive characteristics. China grapples with a staggering 300 million cases, predominantly due to hepatitis B and metabolic non‐alcoholic fatty liver disease. Additionally, hepatocellular carcinoma has become a prevalent which is a lethal type
Feng Zhang, Jiaming Ju, Hongtao Diao, Jinglun Song, Yu bian, Baofeng Yang   +5 more
wiley   +1 more source

Immunomodulatory interactions between mesenchymal stromal/stem cells and immune cells in psoriasis: therapeutic potential and challenges. [PDF]

Stem Cell Res Ther
Dashti M, Mohammadi M, Dehnavi S, Sadeghi M.   +3 more
europepmc   +1 more source

G protein‐coupled receptor‐mediated autophagy in health and disease

British Journal of Pharmacology, EarlyView.
G protein‐coupled receptors (GPCRs) constitute the largest and most diverse superfamily of mammalian transmembrane proteins. These receptors are involved in a wide range of physiological functions and are targets for more than a third of available drugs in the market. Autophagy is a cellular process involved in degrading damaged proteins and organelles
Devrim Öz‐Arslan, Zeynep Aslıhan Durer, Beki Kan   +2 more
wiley   +1 more source

Assessing Liver Function in Rat Models of Acute Liver Failure Using Single-Photon Emission Computed Tomography and Cytokine Levels. [PDF]

PLoS One
Xie L, Huang L, Fang X, Zha J, Su Y.
europepmc   +1 more source

Novel CHI3L1‐Associated Angiogenic Phenotypes Define Glioma Microenvironments: Insights From Multi‐Omics Integration

Cancer Science, Volume 116, Issue 5, Page 1433-1448, May 2025.
We propose a novel CHI3L1‐associated vascular phenotype classification for glioma, each characterized by unique tumor features, including immune cell infiltration, metabolic reprogramming, and genomic alterations. We identified CHI3L1‐associated vascular signatures that reflect tumor angiogenesis and immunosuppression.
Yu‐Hang Zhao, Yu‐Xiang Cai, Zhi‐Yong Pan, Feng Tang, Chao Ma, Ze‐Fen Wang, Gang Li, Hang Chang, Su‐Fang Tian, Zhi‐Qiang Li   +9 more
wiley   +1 more source

Diacylglycerol kinase alpha regulates post-hepatectomy liver regeneration. [PDF]

Sci Rep
Nakamoto H, Shichi S, Shirakawa C, Suzuki T, Kitamura H, Taketomi A.   +5 more
europepmc   +1 more source

Scutellarin Alleviates Bone Marrow Mesenchymal Stromal Cellular Senescence via the Ezh2‐Nrf2 Signalling Axis in Diabetes‐Induced Bone Loss

Cell Proliferation, Volume 58, Issue 4, April 2025.
The Ezh2‐Nrf2 signalling axis plays a crucial role in mediating the beneficial effects of SCU under DOP conditions. ABSTRACT Currently, there is no specific treatment for diabetes‐induced osteoporosis (DOP). Our study identified diabetes‐induced cellular senescence, marked by elevated activity of senescence‐associated β‐galactosidase.
Tiantian Wang, Jiehao Chen, Bo Qu, Dong Zhou, Zhen Hong   +4 more
wiley   +1 more source

Ginseng and its functional components in non-alcoholic fatty liver disease: therapeutic effects and multi-target pharmacological mechanisms. [PDF]

Front Pharmacol
Xiao P, Ye Z, Li X, Feng Q, Su Y.
europepmc   +1 more source

Prime Editing: A Revolutionary Technology for Precise Treatment of Genetic Disorders

Cell Proliferation, Volume 58, Issue 4, April 2025.
This review outlines the latest research advancements in prime editing technology, delivery strategies, and the challenges that must be addressed to fully realize its therapeutic potential, emphasizing the high potential of prime editing in the remission or cure of genetic diseases. ABSTRACT Genetic diseases have long posed significant challenges, with
Mengyao Li, Yi Lin, Qiang Cheng, Tuo Wei
wiley   +1 more source