Results 271 to 280 of about 334,700 (354)

Mechanisms of sepsis-induced acute liver injury: a comprehensive review. [PDF]

Front Cell Infect Microbiol
Guo Y, Guo W, Chen H, Sun J, Yin Y.
europepmc   +1 more source

DNA Damage Repair in Glioblastoma: A Novel Approach to Combat Drug Resistance

Cell Proliferation, EarlyView.
Glioblastoma (GBM) stem cells are useful model for in vitro drug characterisation. DNA repair mechanisms can contribute to cancer cell survival. Pt(IV) bearing Histone DeACetylase inhibitors enhances anticancer effects by disrupting DNA damage response. Poly ADP ribose polymerases inhibitors could adjuvate GBM treatment.
Ludovica Gaiaschi, Claudio Casali, Andrea Stabile, Sharon D'Amico, Mauro Ravera, Elisabetta Gabano, Andrea Galluzzo, Cristina Favaron, Federica Gola, Fabrizio De Luca, Serena Pellegatta, Maria Grazia Bottone   +11 more
wiley   +1 more source

Super‐Enhancer Target Gene CBP/p300‐Interacting Transactivator With Glu/Asp‐Rich C‐Terminal Domain, 2 Cooperates With Transcription Factor Forkhead Box J3 to Inhibit Pulmonary Vascular Remodeling

Cell Proliferation, EarlyView.
During hypoxia, the transcriptional effect of super‐enhancer in promoting CBP/p300‐interacting transactivator with Glu/Asp‐rich C‐terminal domain, 2 reduced, eventually leading to the thickening of the smooth muscle layer of the pulmonary artery.
Songyue Li, Jingya Zhang, Xu Wang, Xinru Wang, Yuyu Song, Xinyue Song, Xiuli Wang, Weiwei Cao, Chong Zhao, Jing Qi, Xiaodong Zheng, Yan Xing   +11 more
wiley   +1 more source

The Active Components of Traditional Chinese Medicines Regulate the Multi-Target Signaling Pathways of Metabolic Dysfunction-Associated Fatty Liver Disease. [PDF]

Drug Des Devel Ther
Song Z, Bu S, Sang S, Li J, Zhang X, Song X, Ran Y.   +6 more
europepmc   +1 more source

Tetraspanin CD53 Promotes Inflammation but Restrains Mucus Production in a Mouse Model of Allergic Airway Inflammation

Allergy, Volume 80, Issue 4, Page 1127-1131, April 2025.
Amy T. Hsu, Viktor Bugajev, Timothy A. Gottschalk, Livia Demkova, Lucie Potuckova, Lubica Draberova, Monika Bambouskova, Philipp Hagemann, Caitlin A. O'Brien, Martin Riecan, Ondrej Kuda, Evelyn Tsantikos, Petr Draber, Mark D. Wright, Annemiek B. van Spriel, Margaret L. Hibbs, Ivana Halova   +16 more
wiley   +1 more source

Organoid Models to Study Human Infectious Diseases

Cell Proliferation, EarlyView.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu, Dan Chen, Xinzhi Yang, Liuliu Yang, Yuling Han   +4 more
wiley   +1 more source

Preventive and Therapeutic Effects of Baicalein, Galangin, and Isorhamnetin in Chronic Liver Diseases: A Narrative Review. [PDF]

Molecules
Scarlata GGM, Lopez I, Gambardella ML, Milanović M, Milić N, Abenavoli L.   +5 more
europepmc   +1 more source

PD‐L1 Promotes Immunological Tolerance and Enhances Visual Protection of hESC‐RPE Grafts in Retinal Degeneration

Cell Proliferation, EarlyView.
We generated immune‐tolerant mature hESC‐RPE cells by overexpressing PD‐L1. PD‐L1‐expressing hESC‐RPE grafts exhibited significantly higher survival, reduced apoptosis and enhanced visual protection in retinal degeneration models, which presents an alternative target to improve the efficiency of hESC‐RPE‐based therapy for AMD. ABSTRACT Immune rejection
Bowen Li, Xue Zhang, Yajie Fang, Min Chen, Qiyou Li, Yuxiao Zeng, Chunge Ren, Chengang Wang, Yingxue Lv, Jia Lu, Hongling Liu, Yong Liu   +11 more
wiley   +1 more source

In Silico Analysis Identified Putative Pathogenic Missense Single Nucleotide Polymorphisms (SNPs) in the Human <i>HNF1A</i> Gene. [PDF]

Int J Mol Sci
Aldharee H, Hamdan HZ.
europepmc   +1 more source

Targeting Regulation of Macrophage to Treat Metabolic Disease: Role of Phytochemicals

Cell Proliferation, EarlyView.
One‐third of the world's population is affected by metabolic syndrome. Complicated pathogenesis and limited drugs cause the growing prevalence of metabolic syndrome. Macrophage‐mediated metaflammation is closely associated with the development of metabolic syndrome. The role of phytochemicals targeting macrophages in the treatment of metabolic syndrome
Zeting Ye, Yanlin Li, Xiaolin Yang, Chenglin Li, Rui Yu, Guangjuan Zheng, Zuqing Su   +6 more
wiley   +1 more source