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Hepatocyte Nuclear Factor 1-Beta [PDF]
Definitions, 2020 National Cancer Institute
semanticscholar +3 more sources
Hepatocyte nuclear factor 1 beta induces transformation and epithelial‐to‐mesenchymal transition
FEBS Letters, 2016 Gene amplification can be a cause of cancer, and driver oncogenes have been often identified in amplified regions. However, comprehensive analysis of other genes coamplified with an oncogene is rarely performed. We focused on the 17q12–21 amplicon, which contains ERBB2.
Atsuka Matsui +6 more
semanticscholar +4 more sources
, 2017 Background: Arias-Stella reaction is a spectrum of benign cellular changes which is associated with exogenous progestogens or pregnancy. Histologically, this reaction is characterized by striking nuclear atypia with or without clear cytoplasm and can potentially mimic clear cell carcinoma.
Szu-yen Wang
semanticscholar +3 more sources
FP054PHENOTYPIC ANALYSIS OF A COHORT OF PATIENTS WITH HEPATOCYTE NUCLEAR FACTOR 1 BETA (HNF1b) MUTATIONS [PDF]
Nephrology Dialysis Transplantation, 2015 Emma Montgomery, John A. Sayer
semanticscholar +3 more sources
MODY: Strategies for a unique form of diabetes [PDF]
Journal of Education and Health PromotionMaturity-onset diabetes of the young (MODY) is a monogenic, autosomal dominant form of diabetes that typically presents before the age of 25. It is caused by mutations in single genes involved in insulin production and glucose regulation, leading to ...
Ram K. Garg
doaj +2 more sources
Journal of Biological Chemistry, 1994 Hepatocyte nuclear factor-1 alpha (HNF-1 alpha) and HNF-1 beta are transcription factors that contain a divergent homeodomain, bind to DNA as homo- or heterodimers, and act to regulate transcription of many genes that are expressed primarily in liver.
Gary D. Wu +3 more
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Nonsense and Missense Mutations in the Human Hepatocyte Nuclear Factor-1β Gene (TCF2) and Their Relation to Type 2 Diabetes in Japanese [PDF]
The Journal of Clinical Endocrinology & Metabolism, 2002 Mutations in transcription factors expressed in the pancreatic beta-cell are a major cause of maturity-onset diabetes of the young (MODY). They have also been found in patients diagnosed with type 1 and type 2 diabetes mellitus, which may highlight the difficulty in diagnosing these forms of diabetes or perhaps indicate a direct role in the development
Hiroto, Furuta +7 more
openaire +3 more sources
The Journal of the Japanese Society of Clinical Cytology, 2008 目的 : 子宮体部明細胞腺癌 (以下, 明細胞腺癌) および類内膜腺癌の hepatocyte nuclear factor-1 beta (以下, HNF-1β) 発現について酵素抗体法を用いた検討を行った.方法 : 組織, 細胞学的に子宮体部腺癌と診断された 38 例 (明細胞腺癌 : 6 例, 類内膜腺癌 G1 : 15 例, G2 : 12 例, G3 : 5 例) を用いた. 判定に際しては, 腫瘍細胞の核に発現を示すものを陽性とし, 半定量的に評価した (− : 陰性, 1+ : 30%以下, 2+ : 30∼70%, 3+ : 70%以上).成績 : 明細胞腺癌における HNF-1β発現は, 細胞, 組織標本のいずれも全例に種々の程度で認められた.
Naruaki Matsui +8 more
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Pseudopregnancy induces the expression of hepatocyte nuclear factor-1β and its target gene aminopeptidase N in rabbit endometrium via the epithelial promoter [PDF]
Biochemical Journal, 1995 The rabbit endometrium is an excellent model system allowing experimental manipulation of aminopeptidase N (APN) mRNA expression in vivo. By RNase mapping and sequencing of cloned PCR-amplified primer-extended RNA, it was demonstrated that endometrial APN expression is directed by the epithelial APN promoter and is increased in human-choriogonadotropin-
Classen-Linke, I +3 more
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Journal of Nutritional Science and Vitaminology, 2006 Hepatocyte nuclear factor (HNF)-1alpha and HNF-1beta are concerned in sucrase-isomaltase (SI) gene expression, and directly bind two sites (SIF2, SIF3) of the promoter of the SI gene. However, it is not completely clear that HNF-1alpha and HNF-1beta play a role in regulation of SI gene expression.
Ning Gu +7 more
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