Results 21 to 30 of about 58,347 (252)

Chromatin recruitment of activated AMPK drives fasting response genes co-controlled by GR and PPARα [PDF]

, 2016
Adaptation to fasting involves both Glucocorticoid Receptor (GRα) and Peroxisome Proliferator-Activated Receptor α (PPARα) activation. Given both receptors can physically interact we investigated the possibility of a genome-wide cross-talk between ...
Bougarne, Nadia, Caron, Sandrine, De Bosscher, Karolien, De Cauwer, Lode, Hennuyer, Nathalie, Libert, Claude, Lievens, Sam, Mylka, Viacheslav, Paumelle, Réjane, Pawlak, Michal, Ratman, Dariusz, Rider, Mark H, Staels, Bart, Tavernier, Jan, Thommis, Jonathan   +14 more
core   +3 more sources

Germline hepatocyte nuclear factor 1α and 1β mutations in renal cell carcinomas [PDF]

Human Molecular Genetics, 2005
Mutations in one copy of the hepatocyte nuclear factors (HNF) 1alpha and 1beta homeodomain containing transcription factors predispose the carrier to maturity-onset diabetes of the young (MODY) types 3 and 5, respectively. Moreover, previous identification of biallelic inactivation of HNF1alpha in hepatocellular adenoma identified its tumor suppressor ...
Rebouissou, Sandra, Vasiliu, Viorel, Thomas, Cristel, Bellanne-Chantelot, Christine, Bui, Hung, Chretien, Yves, Timsit, José, Rosty, Christophe, Laurent-Puig, Pierre, Chauveau, Dominique, Zucman-Rossi, Jessica   +10 more
openaire   +4 more sources

The lncRNA HOTAIR transcription is controlled by HNF4α-induced chromatin topology modulation [PDF]

, 2018
The expression of the long noncoding RNA HOTAIR (HOX Transcript Antisense Intergenic RNA) is largely deregulated in epithelial cancers and positively correlates with poor prognosis and progression of hepatocellular carcinoma and gastrointestinal cancers.
A Busanello, AL Cattin, AM Cozzolino, C Battistelli, C Battistelli, C Battistelli, C Cicchini, C Cicchini, C Cicchini, C Padua Alves, Carla Cicchini, Cecilia Battistelli, Claudia Montaldo, DW Dodd, E Bolotin, F Garibaldi, F Parviz, Frank J. Gonzalez, Giovanna Sabarese, H Hagege, J Dekker, JA Bonzo, JL Rinn, K Kim, L Amicone, L Santangelo, Laura Santangelo, M Darsigny, MA Battle, Marco Tripodi, MC Tsai, MJ Milevskiy, N Skrypek, NL Lazarevich, R Kogo, RA Gupta, RE Hewitt, S Holwerda, S Satohisa, S Sekiya, SH Ahn, T Oshima, WD Garrison, Y Kamiyama, Y Nie, Y Qiao, Y Ren, YJ Geng, Z Chen, Z Yang, ZH Wu, ZQ Wu   +51 more
core   +1 more source

YAP integrates the regulatory Snail/HNF4α circuitry controlling epithelial/hepatocyte differentiation [PDF]

, 2019
Yes-associated protein (YAP) is a transcriptional co-factor involved in many cell processes, including development, proliferation, stemness, differentiation, and tumorigenesis.
Amicone, Laura, Battistelli, Cecilia, Cicchini, Carla, Consalvi, Veronica, Cozzolino, Angela Maria, Marchetti, Alessandra, Noce, Valeria, Strippoli, Raffaele, Tripodi, Marco   +8 more
core   +1 more source

Nonsense and Missense Mutations in the Human Hepatocyte Nuclear Factor-1β Gene (TCF2) and Their Relation to Type 2 Diabetes in Japanese [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2002
Mutations in transcription factors expressed in the pancreatic beta-cell are a major cause of maturity-onset diabetes of the young (MODY). They have also been found in patients diagnosed with type 1 and type 2 diabetes mellitus, which may highlight the difficulty in diagnosing these forms of diabetes or perhaps indicate a direct role in the development
Tadashi Hanabusa, Kunihiro Ekawa, Kishio Nanjo, Hideyuki Sasaki, Tokio Sanke, Hiroto Furuta, Machi Furuta, Masahiro Nishi   +7 more
openaire   +2 more sources

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source

HNF1B defitsiidi sündroom – haigusjuhu kirjeldus ja kirjanduse ülevaade [PDF]

HNF1B (hepatocyte nuclear factor 1 beta) defitsiidi sündroom on harva esinev geneetiline haigus, mida põhjustab HNF1B geeni haigusseoseline muutus või kogu geeni deletsioon.
Botchorishvili, Ana, Kull, Karin
core   +2 more sources

Role of High-Mobility Group Box-1 in Liver Pathogenesis [PDF]

, 2019
High-mobility group box 1 (HMGB1) is a highly abundant DNA-binding protein that can relocate to the cytosol or undergo extracellular release during cellular stress or death. HMGB1 has a functional versatility depending on its cellular location.
Huda, Nazmul, Khambu, Bilon, Yan, Shengmin, Yin, Xiao-Ming   +3 more
core   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Effect of Urtica dioica L extract on quantitative morphometric alterations of liver parenchymal cells in STZ diabetic rats [PDF]

, 2009
Diabetes is associated with several structural and functional liver abnormalities that affect glycogen and lipid metabolism. In this study, an attempt was made to evaluate the effects of hydroalcoholic extract of Urtica dioica leaves on Quantitative ...
Farsi, M.M., Ghafari, S., Golalipour, M.J.   +2 more
core   +1 more source