Results 101 to 110 of about 136,980 (341)

Synthetic Nanobiology Actuated Lipometabolic Cell Factory for Autologous Tumor Immunotherapy

Advanced Functional Materials, EarlyView.
FA plays a crucial role in the interaction between tumor cells and the tumor microenvironment, especially for the immune response. A biocatalytic immunoenhancement strategy is developed to boost antitumor immunity by FA metabolic orientation to ceramide. Through the design of this delicate catalytic immunoenhancement strategy, the synthetic nanobiology
Shoujie Zhao, Yejing Zhu, Hengchao Yu, Jun Zhu, Bo Wang, Yu Qiao, Zhimin Tian, Junlong Zhao, Lei Liu   +8 more
wiley   +1 more source

Impaired RelA signaling and lipid metabolism dysregulation in hepatocytes: driving forces in the progression of metabolic dysfunction-associated steatotic liver disease

Cell Death Discovery
RelA, also known as nuclear factor kappa B p65, plays a crucial role in the pathogenesis of various liver diseases. However, the specific role of RelA in hepatocytes during the progression of metabolic dysfunction-associated steatotic liver disease ...
Yihuai He, Jinlian Jiang, Lili Ou, Yunfen Chen, Aikedaimu Abudukeremu, Guimei Chen, Weiwei Zhong, Zhigang Jiang, Nuerbiye Nuermaimaiti, Yaqun Guan   +9 more
doaj   +1 more source

TRIB1 regulates liver regeneration by antagonizing the NRF2-mediated antioxidant response

Cell Death and Disease, 2023
Robust regenerative response post liver injuries facilitates the architectural and functional recovery of the liver. Intrahepatic redox homeostasis plays a key role in liver regeneration.
Xinyue Sun, Shuai Wang, Xiulian Miao, Sheng Zeng, Yan Guo, Anqi Zhou, Ying Chen, Yifei Chen, Fangqiao Lv, Zhiwen Fan, Yutong Wang, Yong Xu, Zilong Li   +12 more
doaj   +1 more source

Effect of cyclosporine on hepatic energy status and on fructose metabolism after portacaval shunt in dog as monitored by phosphorus‐31 nuclear magnetic resonance spectroscopy in vivo [PDF]

, 1991
The effect of cyclosporin A on the hepatic energy status and intracellular pH of the liver and its response to a fructose challenge has been investigated using in vivo phosphorus‐31 nuclear magnetic resonance spectroscopy in dogs.
Atkinson, Avison, Baldassarri, Bode, Bäckman, Calne, Cohen, Evelhoch, Francavilla, Grant, Harder, Iles, Iles, Kahn, Kim, Kim, Klintmalm, Laupacis, Loertscher, Lorber, Makowka, Mazzaferro, Otte, Powles, Roos, Rossaro, Schade, Seo, Stacey, Starzl, Starzl, Starzl, Starzl, Starzl, Stone, Thompson, Van Thiel, Ziegler   +37 more
core   +1 more source

Hepatocyte-derived IL-10 plays a crucial role in attenuating pathogenicity during the chronic phase of T. congolense infection [PDF]

, 2020
Bovine African Trypanosomosis is an infectious parasitic disease affecting livestock productivity and thereby impairing the economic development of Sub-Saharan Africa. The most important trypanosome species implicated is T.
Brys, Lea, De Baetselier, Patrick, De Trez, Carl, Korf, Hannelie, Magez, Stefan, Stijlemans, Benoit, Van Ginderachter, Jo A   +6 more
core   +1 more source

Membrane Fusion‐Inspired Nanomaterials: Emerging Strategies for Infectious Disease and Cancer Diagnostics

Advanced Healthcare Materials, EarlyView.
Membrane fusion‐inspired nanomaterials offer transformative potential in diagnostics by mimicking natural fusion processes to achieve highly sensitive and specific detection of disease biomarkers. This review highlights recent advancements in nanomaterial functionalization strategies, signal amplification systems, and stimuli‐responsive fusion designs,
Sojeong Lee, Khulan Nyamzaya, Jueun Han, Yejin Song, Jihee Lee, Jung Hyun Jo, Seungmin Bang, Eun‐Kyung Lim, Seungjoo Haam, Eunjung Kim   +9 more
wiley   +1 more source

Improved Progression-Free Survival in Irinotecan-Treated Metastatic Colorectal Cancer Patients Carrying the HNF1A Coding Variant p.I27L

Frontiers in Pharmacology, 2017
Hepatocyte nuclear factor 1-alpha (HNF1A) is a liver-enriched transcription factor that plays a key role in many aspects of hepatic functions including detoxification processes.
Adrien Labriet, Adrien Labriet, Elena De Mattia, Erika Cecchin, Éric Lévesque, Éric Lévesque, Derek Jonker, Félix Couture, Félix Couture, Angela Buonadonna, Mario D’Andrea, Lyne Villeneuve, Lyne Villeneuve, Giuseppe Toffoli, Chantal Guillemette, Chantal Guillemette   +15 more
doaj   +1 more source

A Human Kidney Tubuloid Model of Repeated Cisplatin‐Induced Cellular Senescence and Fibrosis for Drug Screening

Advanced Healthcare Materials, EarlyView.
Replicating aging and senescence‐related pathophysiological responses in kidney organoids remains a significant challenge. Human adult renal tubular organoid, tubuloids, are successfully developed recapitulating cellular senescence that is the central pathophysiological mechanism of chronic kidney disease (CKD).
Yuki Nakao, Makiko Mori, Yuta Sekiguchi, Iori Morita, Ryota Shindoh, Shintaro Mandai, Tamami Fujiki, Hiroaki Kikuchi, Fumiaki Ando, Koichiro Susa, Takayasu Mori, Ayumi Suzuki, Yuji Nashimoto, Hirokazu Kaji, Yuma Waseda, Soichiro Yoshida, Yasuhisa Fujii, Eisei Sohara, Shinichi Uchida, Kensuke Miyake, Yutaro Mori   +20 more
wiley   +1 more source

TG-interacting factor 1 acts as a transcriptional repressor of sterol O-acyltransferase 2[S]

Journal of Lipid Research, 2014
Acat2 [gene name: sterol O-acyltransferase 2 (SOAT2)] esterifies cholesterol in enterocytes and hepatocytes. This study aims to identify repressor elements in the human SOAT2 promoter and evaluate their in vivo relevance.
Camilla Pramfalk, Tiffany A. Melhuish, David Wotton, Zhao-Yan Jiang, Mats Eriksson, Paolo Parini   +5 more
doaj   +1 more source

Self‐Organizing Human Induced Pluripotent Stem Cell Hepatocyte 3D Organoids Inform the Biology of the Pleiotropic TRIB1 Gene

Hepatology Communications, 2020
Establishment of a physiologically relevant human hepatocyte‐like cell system for in vitro translational research has been hampered by the limited availability of cell models that accurately reflect human biology and the pathophysiology of human disease.
Deepti Abbey, Susannah Elwyn, Nicholas J. Hand, Kiran Musunuru, Daniel J. Rader   +4 more
doaj   +1 more source