Results 101 to 110 of about 993,672 (387)

Pion form factor using domain wall valence and asqtad sea quarks [PDF]

Nucl.Phys.Proc.Suppl.140:302-304,2005, 2004
We compute the pion electromagnetic form factor in a hybrid calculation with domain wall valence quarks and improved staggered (asqtad) sea quarks. This method can easily be extended to rho-to-gamma-pi transition form factors.
arxiv   +1 more source

A novel technique for selective NF-kappa B inhibition in Kupffer cells: contrary effects in fulminant hepatitis and ischaemia-reperfusion. [PDF]

, 2009
Background and aims: The transcription factor nuclear factor kappa B (NF-kB) has risen as a promising target for anti-inflammatory therapeutics. In the liver, however, NFkB inhibition mediates both damaging and protective effects.
A. Hartkorn, A. L. Gerbes, A. M. Vollmar, C. Coester, F. Hoffmann, G. Sass, G. Tiegs, G. Winter, J. Wagner, J. Zillies, S. Fuchs, S. Zahler   +11 more
core   +1 more source

An indirect negative autoregulatory mechanism involved in hepatocyte nuclear factor-1 gene expression [PDF]

Nucleic Acids Research, 1993
Recent studies have revealed that hepatocyte nuclear factor 4 (HNF-4) is an essential positive regulator of another liver enriched transcription factor HNF-1, defining a transcriptional hierarchy between the two factors operating in hepatocytes. To assess the possible autoregulation of the HNF-1 gene we have examined the effect of HNF-1 on its own ...
Aristeidis Kritis, Iannis Talianidis, Barda D, Ktistaki E, Vassilis I. Zannis   +4 more
openaire   +3 more sources

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

Role of Intrasplenic Hepatocyte Transplantation in Improving Survival and Liver Regeneration after Hepatic Resection in Cirrhotic Rats

Cell Transplantation, 2002
We studied the effect of preoperative hepatocyte transplantation on the prevention of liver failure in cirrhotic rats after hepatic resection. Two groups of Lewis rats were rendered cirrhotic by IP injection of 1% dimethylnitrosamine and were subjected ...
Tarik A. Ahmad M.D., Susumu Eguchi, Katsuhiko Yanaga, Shungo Miyamoto, Yukio Kamohara, Hikaru Fujioka, Junichiro Furui, Takashi Kanematsu   +7 more
doaj   +1 more source

Effects of Diabetes Mellitus on Hepatocyte Nuclear Factor 1 Decrease Albumin Gene Transcription [PDF]

Journal of Biological Chemistry, 1996
We have previously reported that albumin gene transcription is reduced in diabetes mellitus (DM). The present study explored the mechanism by which albumin gene transcription is down-regulated in DM. Deletional studies and displacement of factors binding to site B of the albumin promoter indicated that the repressive effects of DM are mediated by ...
Norman C.W. Wong, Irene Wanke, Gonzalo Barrera-Hernandez   +2 more
openaire   +2 more sources

RIPK1 protects from TNF-α-mediated liver damage during hepatitis [PDF]

, 2016
Cell death of hepatocytes is a prominent characteristic in the pathogenesis of liver disease, while hepatolysis is a starting point of inflammation in hepatitis and loss of hepatic function.
Bertin, John, Bertrand, Mathieu, Dimanche-Boitrel, Marie-Thérèse, Farooq, Muhammad, Filliol, Aveline, Genet, Valentine, Gough, Peter J, Le Seyec, Jacques, Lucas-Clerc, Catherine, Piquet-Pellorce, Claire, Samson, Michel, Vandenabeele, Peter   +11 more
core   +1 more source

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

The Hepatocyte nuclear factor-1 alpha (HNF1A) gene is associated with fatness and loin muscle area in the pig

Animal, 2010
The significance of hepatocyte nuclear factors (HNFs) in β-cell development and function has been generally recognized in humans, as evidenced by their associations with cases of maturity onset diabetes of the young (MODY).
B. Fan, Z.-Q. Du, M.F. Rothschild
doaj  

Identification of nine novel mutations in the hepatocyte nuclear factor 1 alpha gene associated with maturity-onset diabetes of the young (MODY3).

Human Molecular Genetics, 1997
Maturity-onset diabetes of the young (MODY) is a genetically heterogeneous subtype of non-insulin-dependent diabetes mellitus (NIDDM) characterised by early onset, autosomal dominant inheritance and a primary defect in insulin secretion.
M. Vaxillaire, M. Vaxillaire, M. Rouard, K. Yamagata, K. Yamagata, N. Oda, P. Kaisaki, P. Kaisaki, V. V. Boriraj, J. Chévre, V. Boccio, R. Cox, G. Lathrop, P. Dussoix, J. Philippe, J. Timsit, G. Charpentier, G. Velho, G. Bell, G. Bell, P. Froguel   +20 more
semanticscholar   +1 more source