Results 221 to 230 of about 86,113 (258)

Expression ratio of hepatocyte nuclear factor-1 to variant hepatocyte nuclear factor-1 in differentiation of hepatocellular carcinoma and hepatoblastoma

Journal of Hepatology, 1996
Liver-specific protein genes have multiple cis-/trans-acting elements, but those accountable for hepatocytic differentiation are unclear. An AT-rich core sequence (AT motif) is essential as a cis-acting element for the hepatic transcription. Homologous proteins hepatocyte nuclear factor-1 (HNF-1) and variant HNF-1 (vHNF-1) bind to this motif. The ratio
Kiyofumi Saijoh, T Tamaoki, H Nakabayashi   +2 more
exaly   +3 more sources

Modulation of Hepatic Gene Expression by Hepatocyte Nuclear Factor 1

Science, 1997
Hepatocyte nuclear factors 1 and 4 (HNF-1 and HNF-4) are liver-enriched transcription factors that function in the regulation of several liver-specific genes. HNF-1 activates genes containing promoters with HNF-1 binding sites. However, this factor negatively regulates its own expression and that of other HNF-4–dependent genes that lack HNF-1 binding ...
E, Ktistaki, I, Talianidis
openaire   +2 more sources

Activity of hepatocyte nuclear factor 1α and hepatocyte nuclear factor 1β isoforms is differently affected by the inhibition of protein phosphatases 1/2A

Biochemical Journal, 2001
Phosphorylation/dephosphorylation processes are known to control the activity of several transcription factors. The nutrition-dependent expression of sucrase–isomaltase and Na+/glucose co-transporter 1, two proteins implicated in the intestinal absorption of glucose, has been shown to be closely related to modifications of hepatocyte nuclear factor 1 ...
V, Carrière, M, Lacasa, M, Rousset
openaire   +2 more sources

Hepatocyte nuclear factor 1 negatively regulates amylin gene expression

Biochemical and Biophysical Research Communications, 2003
Maturity-onset diabetes of the young (MODY) is a monogenic subtype of Type 2 diabetes, defined as having an early age of onset, with a dominant inheritance pattern. Hepatocyte nuclear factor 1 (HNF1), which is encoded by the MODY3 gene, has been shown to bind the insulin promoter. Since the promoters of three pancreas-specific genes involved in glucose
Green, Janelle, Naot, Dorit, Cooper, Garth   +2 more
openaire   +4 more sources

Variant Hepatocyte Nuclear Factor 1 is required for visceral endoderm specification

Development, 1999
Abstract Genetic and molecular evidence indicates that visceral endoderm, an extraembryonic cell lineage, is required for gastrulation, early anterior neural patterning, cell death and specification of posterior mesodermal cell fates. We show that variant Hepatocyte Nuclear Factor 1 (vHNF1), a homeodomain-containing transcription factor ...
E, Barbacci, M, Reber, M O, Ott, C, Breillat, F, Huetz, S, Cereghini   +5 more
openaire   +2 more sources

Involvement of Hepatocyte Nuclear Factor 1 in the Regulation of the UDP-Glucuronosyltransferase 1A7 (UGT1A7) Gene in Rat Hepatocytes

Molecular Pharmacology, 2000
UDP-glucuronosyltransferase 1A7 (UGT1A7) is a major UGT contributing to the glucuronidation of xenobiotic phenols in rats. Its expression in rat liver is tightly regulated, with low constitutive and high inducible expression in response to aryl hydrocarbon receptor ligands and oltipraz.
R P, Metz, D J, Auyeung, F K, Kessler, J K, Ritter   +3 more
openaire   +2 more sources