Results 231 to 240 of about 86,113 (258)

Deletion of Hepatocyte Nuclear Factor-1-Beta in an Infant with Prune Belly Syndrome

American Journal of Perinatology, 2010
Prune belly syndrome is a rare congenital disorder characterized by deficiency of abdominal wall muscles, cryptorchidism, and urinary tract anomalies. We have had the opportunity to study a baby with prune belly syndrome associated with an apparently de novo 1.3-megabase interstitial 17q12 microdeletion that includes the hepatocyte nuclear factor-1 ...
Sina, Haeri, Patricia L, Devers, Kathleen A, Kaiser-Rogers, Vincent J, Moylan, Beth S, Torchia, Amanda L, Horton, Honor M, Wolfe, Arthur S, Aylsworth   +7 more
openaire   +2 more sources

Frequent mutations of hepatocyte nuclear factor 1 in colorectal cancer with microsatellite instability

Gastroenterology, 2003
The TCF1 gene encoding hepatocyte nuclear factor 1 alpha (HNF1), a transcription factor germline mutated in patients with maturity-onset diabetes of the young type 3, was recently found to be frequently inactivated by biallelic alterations in liver adenoma and in rare hepatocellular carcinomas.
Pierre, Laurent-Puig, Olivier, Plomteux, Olivier, Bluteau, Franck, Zinzindohoué, Emmanuelle, Jeannot, Karin, Dahan, Alex, Kartheuser, Caroline, Chapusot, Paul-Henri, Cugnenc, Jessica, Zucman-Rossi   +9 more
openaire   +2 more sources

Injury induces rapid changes in hepatocyte nuclear factor-1: DNA binding

Surgery, 1996
Transcriptional regulation in the liver plays a critical role in mediating the acute phase response to injury. The molecular mechanisms driving these transcriptional events, however, are poorly defined in vivo. The liver-specific transcription factor hepatocyte nuclear factor (HNF)-1 binds to the 5' upstream region of many acute phase genes. To explore
P A, Burke, M, Luo, J, Zhu, M B, Yaffe, R A, Forse   +4 more
openaire   +2 more sources

Hepatocyte nuclear factor 1 beta induces transformation and epithelial‐to‐mesenchymal transition

FEBS Letters, 2016
Gene amplification can be a cause of cancer, and driver oncogenes have been often identified in amplified regions. However, comprehensive analysis of other genes coamplified with an oncogene is rarely performed. We focused on the 17q12–21 amplicon, which contains ERBB2.
Atsuka, Matsui, Jiro, Fujimoto, Kosuke, Ishikawa, Emi, Ito, Naoki, Goshima, Shinya, Watanabe, Kentaro, Semba   +6 more
openaire   +2 more sources

Hepatocyte nuclear factor-4??/?? and hepatocyte nuclear factor-1?? as causal factors of interindividual difference in the expression of human dihydrodiol dehydrogenase 4 mRNA in human livers

Pharmacogenetics, 2003
Human dihydrodiol dehydrogenase (DD) catalyses the oxidation of trans-dihydrodiols of polycyclic aromatic hydrocarbons and the reduction of several ketone-containing drugs. About 40-fold interindividual difference in DD activities has been noted. Recently, we found that transcriptional factors, hepatocyte nuclear factor (HNF)-1 alpha, HNF-4 alpha and ...
Takeshi, Ozeki, Yoshiki, Takahashi, Kazuo, Nakayama, Masato, Funayama, Kazuo, Nagashima, Takao, Kodama, Tetsuya, Kamataki   +6 more
openaire   +2 more sources

Maturity-Onset Diabetes of the Young Due to a Mutation in the Hepatocyte Nuclear Factor-4α Binding Site in the Promoter of the Hepatocyte Nuclear Factor-1α Gene

Diabetes, 1997
Recent studies have shown that mutations in the transcription factor hepatocyte nuclear factor (HNF)-1α are the cause of one form of maturity-onset diabetes of the young (MODY3). These studies have identified mutations in the mRNA and protein coding regions of this gene that result in the synthesis of an abnormal mRNA or protein.
C, Gragnoli, T, Lindner, B N, Cockburn, P J, Kaisaki, F, Gragnoli, G, Marozzi, G I, Bell   +6 more
openaire   +2 more sources

Hepatocyte nuclear factor-4α and -1 small interfering RNA inhibits hepatocyte differentiation induced by extracellular matrix

Hepatology Research, 2006
Liver-specific genes and hepatocyte nuclear factor (HNF)-4alpha and -1 are coordinately regulated by extracellular matrix (ECM). However, still are unclear interactions between liver-specific genes and these liver-enriched transcription factors in the mechanism of hepatocyte differentiation regulated by ECM. To elucidate the relationship, we used small
Takayuki, Kimata, Masahito, Nagaki, Yoshihiko, Tsukada, Tomio, Ogiso, Hisataka, Moriwaki   +4 more
openaire   +2 more sources

Hepatocyte nuclear factor 1 alpha (HNF-1?) mutations in maturity-onset diabetes of the young

Human Mutation, 2000
Maturity-onset diabetes of the young (MODY) is a monogenic form of diabetes mellitus characterized by autosomal dominant inheritance, early age of onset (
openaire   +2 more sources

Hepatocyte nuclear factor 1A-antisense: Review of its role in the carcinogenesis

Pathology Research and Practice, 2021
Mohammad Taheri, Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht   +2 more
exaly  

Hepatocyte Nuclear Factor 1 Regulates the Expression of OCT1

The Journal of Pharmacology and Experimental Therapeutics, 2013
openaire   +1 more source