Organocatalytic Switches of DNA Glycosylase OGG1 Catalyze a Highly Efficient AP‐Lyase Function
Chemistry – A European Journal, EarlyView.Organocatalytic switches are small molecules that combine active site affinity and a nitrogen‐centered base for catalysis, effectively removing the rate‐determining step of the OGG1 biochemical cascade. Here, we identify a minimal structure and modulate the active nitrogen pKa, enabling the catalysis of ultrafast AP site incisions in a range of pH ...
Mario Kehler +28 more
wiley +1 more source
Exonic Duplication of theHepatocyte Nuclear Factor-1β Gene (Transcription Factor 2, Hepatic) as a Cause of Maturity Onset Diabetes of the Young Type 5 [PDF]
, 2007 Claire Carette +6 more
openalex +1 more source
Recent Cutting‐Edge Technologies for the Delivery of Peptide Nucleic Acid
Chemistry – A European Journal, EarlyView.This review provides an overview of PNA cellular delivery methods, starting with traditional peptide‐based systems and progressing to advanced approaches using nanoparticles, liposomes, and calixarene. It highlights how these innovative strategies have opened the way for more effective and efficient PNA delivery, ultimately enhancing the potential for ...
Concetta Avitabile +4 more
wiley +1 more source
Regulation of Vascular Endothelial Growth Factor D by Orphan Receptors Hepatocyte Nuclear Factor-4α and Chicken Ovalbumin Upstream Promoter Transcription Factors 1 and 2 [PDF]
, 2008 Georgia Schäfer +4 more
openalex +1 more source
Hepatocyte nuclear factor 1β suppresses canonical Wnt signaling through transcriptional repression of lymphoid enhancer–binding factor 1 [PDF]
, 2020 Siu Chiu Chan +4 more
openalex +1 more source
Effects of C2-Ceramide and Oltipraz on Hepatocyte Nuclear Factor-1 and Glutathione S-Transferase A1 in Acetaminophen-Mediated Acute Mice Liver Injury. [PDF]
Front Pharmacol, 2018 Ma X +10 more
europepmc +1 more source
Diagnostic Cytopathology, EarlyView.ABSTRACT Mutations in the DNA polymerase epsilon (POLE) gene are associated with an increased risk of various malignancies, including colorectal and other gastrointestinal, endometrial, ovarian, breast, and brain cancers. In extremely rare cases, POLE mutations have also been associated with pancreatic and hepatobiliary carcinomas.
Lynn Messersmith +3 more
wiley +1 more source
Hepatocyte nuclear factor-4α and bile acids regulate human concentrative nucleoside transporter-1 gene expression [PDF]
, 2009 Kerstin Klein +4 more
openalex +1 more source
Hepatocyte nuclear factor 1 coordinates multiple processes in a model of intestinal epithelial cell function. [PDF]
Biochim Biophys Acta, 2016 Yang R, Kerschner JL, Harris A.
europepmc +1 more source
Environmental and Molecular Mutagenesis, EarlyView.Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal +14 more
wiley +1 more source