Results 311 to 320 of about 136,980 (341)

Hepatocyte nuclear factor-4α and -1 small interfering RNA inhibits hepatocyte differentiation induced by extracellular matrix

Hepatology Research, 2006
Liver-specific genes and hepatocyte nuclear factor (HNF)-4alpha and -1 are coordinately regulated by extracellular matrix (ECM). However, still are unclear interactions between liver-specific genes and these liver-enriched transcription factors in the mechanism of hepatocyte differentiation regulated by ECM. To elucidate the relationship, we used small
Takayuki, Kimata, Masahito, Nagaki, Yoshihiko, Tsukada, Tomio, Ogiso, Hisataka, Moriwaki   +4 more
openaire   +2 more sources

Polymorphismen von HNF1alpha (hepatocyte nuclear factor 1 alpha) bei Gallensteinträgern

Zeitschrift für Gastroenterologie, 2011
Eine Ursache der Gallensteinentstehung kann auf genetische Dispositionen zuruckgefuhrt werden. Der ileale Gallensauretransporter ASBT (apical sodium-dependent bile acid transporter) ist bei Gallensteintragerinnen signifikant erniedrigt (Bergheim, J. Lipid Res. 2006) und zeigt eine genetische Assoziation (Renner, PLoS ONE, 2009) zu Cholelithiasis.
D Richter, S Harsch, S Hirobe-Jahn, A Strohmeyer, S Schimmel, EF Stange   +5 more
openaire   +1 more source

Activity of hepatocyte nuclear factor 1α and hepatocyte nuclear factor 1β isoforms is differently affected by the inhibition of protein phosphatases 1/2A

Biochemical Journal, 2001
Phosphorylation/dephosphorylation processes are known to control the activity of several transcription factors. The nutrition-dependent expression of sucrase–isomaltase and Na+/glucose co-transporter 1, two proteins implicated in the intestinal absorption of glucose, has been shown to be closely related to modifications of hepatocyte nuclear factor 1 ...
V, Carrière, M, Lacasa, M, Rousset
openaire   +2 more sources

Frequent mutations of hepatocyte nuclear factor 1 in colorectal cancer with microsatellite instability

Gastroenterology, 2003
The TCF1 gene encoding hepatocyte nuclear factor 1 alpha (HNF1), a transcription factor germline mutated in patients with maturity-onset diabetes of the young type 3, was recently found to be frequently inactivated by biallelic alterations in liver adenoma and in rare hepatocellular carcinomas.
Pierre, Laurent-Puig, Olivier, Plomteux, Olivier, Bluteau, Franck, Zinzindohoué, Emmanuelle, Jeannot, Karin, Dahan, Alex, Kartheuser, Caroline, Chapusot, Paul-Henri, Cugnenc, Jessica, Zucman-Rossi   +9 more
openaire   +2 more sources

Hepatocyte nuclear factor-4??/?? and hepatocyte nuclear factor-1?? as causal factors of interindividual difference in the expression of human dihydrodiol dehydrogenase 4 mRNA in human livers

Pharmacogenetics, 2003
Human dihydrodiol dehydrogenase (DD) catalyses the oxidation of trans-dihydrodiols of polycyclic aromatic hydrocarbons and the reduction of several ketone-containing drugs. About 40-fold interindividual difference in DD activities has been noted. Recently, we found that transcriptional factors, hepatocyte nuclear factor (HNF)-1 alpha, HNF-4 alpha and ...
Takeshi, Ozeki, Yoshiki, Takahashi, Kazuo, Nakayama, Masato, Funayama, Kazuo, Nagashima, Takao, Kodama, Tetsuya, Kamataki   +6 more
openaire   +2 more sources

[Clinical phenotypes of hepatocyte nuclear factor 1 homeobox b-associated disease].

Zhonghua er ke za zhi = Chinese journal of pediatrics, 2019
Objective: Hepatocyte nuclear factor 1 homeobox b (HNF1B) -associated disease is an autosomal dominant inherited disorder with a variable, multi-systemic phenotype. In China, five adult probands and one child proband with HNF1B-associated disease had been reported, whereas few fetuses are described.
F, Wang, Y, Yao, H X, Yang, C Y, Shi, X X, Zhang, H J, Xiao, H W, Zhang, B G, Su, Y Q, Zhang, J F, Guo, J, Ding   +10 more
openaire   +1 more source

Engineered human hepatocyte organoids enable CRISPR-based target discovery and drug screening for steatosis

Nature Biotechnology, 2023
Delilah F G Hendriks, Jos F Brouwers
exaly  

Immunocytochemical hepatocyte nuclear factor-1.BETA. expression in effusions

The Journal of the Japanese Society of Clinical Cytology, 2010
Tomohisa MACHIDA, Masanori YASUDA, Michio SIMIZU, Norihide MOCHIZUKI, Kenji KAWAI, Hitoshi ITOH, Hiroshi KAJIWARA, Naoya NAKAMURA, Yoshiyuki OSAMURA   +8 more
openaire   +1 more source

Proliferation tracing reveals regional hepatocyte generation in liver homeostasis and repair

Science, 2021
Lingjuan He, Wenjuan Pu, Xiuxiu Liu
exaly  

A hepatocyte-targeting nanoparticle for enhanced hepatobiliary magnetic resonance imaging

Nature Biomedical Engineering, 2022
Hai Ming Fan
exaly